Dolichoectasia of the intracranial arteries in patients with first ischemic stroke
A population‐based study
Abstract
Objective The objective of this study was to estimate the frequency of intracranial arterial dolichoectasia among patients with first ischemic stroke and to compare clinical characteristics, survival, and recurrence in those with and without the abnormality.
Background Dolichoectasia may cause cerebral infarction by thrombosis, embolism, stenosis, or occlusion of deep penetrating arteries.
Methods The chi-square, Fisher's exact, and logrank tests were used to compare clinical characteristics, survival, and recurrence for patients with and without dolichoectasia among the 387 residents of Rochester, MN, who had brain CT or MRI for first cerebral infarction from 1985 through 1989.
Results Twelve patients (3.1%) had dolichoectasia. Patients with dolichoectasia were more likely to have had stroke fitting a clinical and radiographic pattern of lacunar infarction than those without (42% and 17% respectively; p = 0.04). Dolichoectasia was detected in the vertebrobasilar system in eight patients (66.7%), in the carotid system in two patients (16.7%), and in both circulatory systems in two patients (16.7%). There were no significant differences in the following characteristics among those with and without dolichoectasia: age, sex, hypertension, diabetes, smoking, and preceding transient ischemic attack. Patients with dolichoectasia had better survival (relative risk [RR] for death, 0.26; p = 0.04) after first cerebral infarction but higher rates of stroke recurrence (RR, 2.4; p = 0.02).
Conclusions Dolichoectasia is detected in 3% of patients with first cerebral infarction and is associated with better survival but higher rates of stroke recurrence.
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© 1998 by the American Academy of Neurology.
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Published online: June 1, 1998
Published in print: June 1998
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- Hyperintense vessel sign in vertebrobasilar dolichoectasia, BMJ Case Reports, 17, 10, (e260606), (2024).https://doi.org/10.1136/bcr-2024-260606
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- Incidental vascular findings on brain magnetic resonance angiography, The British Journal of Radiology, 96, 1142, (2023).https://doi.org/10.1259/bjr.20220135
- Effect of Jiawei Tongqiao Huoxue decoction in basilar artery dolichoectasia mice through yes-associated protein/transcriptional co-activator with PDZ-binding motif pathway, Journal of Ethnopharmacology, 314, (116599), (2023).https://doi.org/10.1016/j.jep.2023.116599
- Relationships between intracranial arterial dolichoectasia and small vessel disease in patients with ischaemic stroke: a systematic review and meta-analysis, Journal of Neurology, 271, 2, (772-781), (2023).https://doi.org/10.1007/s00415-023-12094-2
- Trigeminal neuralgia secondary to vertebrobasilar dolichoectasia treated with cyberknife stereotactic radiosurgery, Asian Journal of Neurosurgery, 14, 03, (978-980), (2022).https://doi.org/10.4103/ajns.AJNS_53_18
- A 5-year follow-up of intracranial arterial dolichoectasia: A case report and review of literature, Asian Journal of Neurosurgery, 14, 04, (1302-1307), (2022).https://doi.org/10.4103/ajns.AJNS_282_18
- Delayed traumatic intracerebral hemorrhage associated with dolichoectasia of the middle cerebral artery, Radiology Case Reports, 17, 4, (1215-1219), (2022).https://doi.org/10.1016/j.radcr.2022.01.039
- Macrovascular decompression of a dolichoectatic vertebral artery via Kawase approach in a patient suffering from trigeminal neuralgia – A case report, Brain and Spine, 2, (100848), (2022).https://doi.org/10.1016/j.bas.2021.100848
- Prevalence and Clinical Correlates of Intracranial Dolichoectasia in Individuals With Ischemic Stroke, Stroke, 52, 7, (2311-2318), (2021).https://doi.org/10.1161/STROKEAHA.120.032225
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