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October 23, 2001

Gliomas arising in organ transplant recipients: An unrecognized complication of transplantation?

October 23, 2001 issue
57 (8) 1486-1488

Abstract

Reported are six cases of glioma, diagnosed in the last 10 years, arising in organ transplant recipients. Five transplant recipients developed glioblastoma, and one developed oligodendroglioma. None had other risk factors for glioma. Gliomas must be considered in the differential diagnosis of space-occupying lesions in transplant recipients. Although these cases may represent coincidence, the putative HIV–glioma association suggests a pathogenetic link to immunosuppression.

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References

1.
Penn I. The changing pattern of posttransplant malignancies. Transplant Proc . 1991; 23: 1101–1103.
2.
Penn I. Tumors after renal and cardiac transplantation. Hematol Oncol Clin North Am . 1993; 7: 431–445.
3.
Schneck SA, Penn I. De-novo brain tumours in renal-transplant recipients. Lancet . 1971; 1: 983–986.
4.
Blumenthal DT, Raizer JJ, Rosenblum MK, et al. Primary intracranial neoplasms in patients with HIV. Neurology . 1999; 52: 1648–1651.
5.
Hiesse C, Larue JR, Kriaa F, et al. Incidence and type of malignancies occurring after renal transplantation in conventionally and in cyclosporine-treated recipients: single-center analysis of a 20-year period in 1600 patients. Transplant Proc . 1995; 27: 2450–2451.
6.
Velema JP, Walker AM. The age curve of nervous system tumour incidence in adults: common shape but changing levels by sex, race and geographical location. Int J Epidemiol . 1987; 16: 177–183.
7.
Hojo M, Morimoto T, Maluccio M, et al. Cyclosporine induces cancer progression by a cell-autonomous mechanism. Nature . 1999; 397: 530–534.
8.
Campbell AN, Chan HS, Becker LE, et al. Extracranial metastases in childhood primary intracranial tumors. A report of 21 cases and review of the literature. Cancer . 1984; 53: 974–981.
9.
Detry O, Honore P, Hans MF, et al. Organ donors with primary central nervous system tumor. Transplantation . 2000; 70: 244–248.
10.
Chui AK, Herbertt K, Wang LS, et al. Risk of tumor transmission in transplantation from donors with primary brain tumors: an Australian and New Zealand registry report. Transplant Proc . 1999; 31: 1266–1267.

Information & Authors

Information

Published In

Neurology®
Volume 57Number 8October 23, 2001
Pages: 1486-1488
PubMed: 11673595

Publication History

Received: March 13, 2001
Accepted: June 12, 2001
Published online: October 23, 2001
Published in print: October 23, 2001

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Authors

Affiliations & Disclosures

D. Schiff, MD
From the Department of Neurological Surgery (Dr. Schiff), University of Pittsburgh Medical Center, PA; Department of Neurology (Drs. O’Neill and Widjicks), Mayo Clinic, Rochester, MN; and Center for Neuro-Oncology (Dr. Wen), Dana Farber Cancer Institute (Dr. Antin), Boston, MA.
B. O’Neill, MD
From the Department of Neurological Surgery (Dr. Schiff), University of Pittsburgh Medical Center, PA; Department of Neurology (Drs. O’Neill and Widjicks), Mayo Clinic, Rochester, MN; and Center for Neuro-Oncology (Dr. Wen), Dana Farber Cancer Institute (Dr. Antin), Boston, MA.
E. Wijdicks, MD
From the Department of Neurological Surgery (Dr. Schiff), University of Pittsburgh Medical Center, PA; Department of Neurology (Drs. O’Neill and Widjicks), Mayo Clinic, Rochester, MN; and Center for Neuro-Oncology (Dr. Wen), Dana Farber Cancer Institute (Dr. Antin), Boston, MA.
J. H. Antin, MD
From the Department of Neurological Surgery (Dr. Schiff), University of Pittsburgh Medical Center, PA; Department of Neurology (Drs. O’Neill and Widjicks), Mayo Clinic, Rochester, MN; and Center for Neuro-Oncology (Dr. Wen), Dana Farber Cancer Institute (Dr. Antin), Boston, MA.
P. Y. Wen, MD
From the Department of Neurological Surgery (Dr. Schiff), University of Pittsburgh Medical Center, PA; Department of Neurology (Drs. O’Neill and Widjicks), Mayo Clinic, Rochester, MN; and Center for Neuro-Oncology (Dr. Wen), Dana Farber Cancer Institute (Dr. Antin), Boston, MA.

Notes

Address correspondence and reprint requests to Dr. D. Schiff, Neuro-Oncology Program, University of Pittsburgh Medical Center, 3471 Fifth Ave., Kaufmann Building, Suite 802, Pittsburgh, PA 15213; e-mail: [email protected]

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