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March 12, 2002

Spontaneous CSF leaks: Underlying disorder of connective tissue

March 12, 2002 issue
58 (5) 814-816

Abstract

Of 58 consecutive patients with spontaneous CSF leaks, nine exhibited features of connective tissue disorder. One had Marfan’s syndrome. Five additional patients had hyperflexible joints, of whom four had arachnodactyly, four were tall and slender, two had hyperextensible skin, and one had a strong family history of abdominal aorta aneurysms. Retinal detachment at a young age was noted in two. One patient had bilateral carotid dissections. A dural weakness may predispose patients to spontaneous CSF leak.

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References

1.
Mokri B, Piepgras DG, Miller GM. Syndrome of orthostatic headaches and diffuse pachymeningeal gadolinium enhancement. Mayo Clin Proc . 1997; 72: 400–413.
2.
Davenport RJ, Chataway SJ, Warlow CP. Spontaneous intracranial hypotension from a CSF leak in a patient with Marfan’s syndrome. J Neurol Neurosurg Psychiatry . 1995; 59: 516–519.
3.
Erkulvrawatr S, El Gammal T, Hawkins J, Green JB, Srinivasan G. Intrathoracic meningoceles and neurofibromatosis. Arch Neurol . 1979; 36: 557–559.
4.
Philip N, Andrac L, Moncla A, et al. Multiple lateral meningoceles, distinctive facies and skeletal anomalies: a new case of Lehman syndrome. Clin Dysmorphol . 1995; 4: 347–351.
5.
Fattori R, Nienaber CA, Descovich B, et al. Importance of dural ectasia in phenotypic assessment of Marfan’s syndrome. Lancet . 1999; 354: 910–913.
6.
Dietz HC, Pyeritz RE. Mutations in the human gene for fibrillin-1 (FBN1) in the Marfan syndrome and related disorders. Hum Mol Genet . 1995; 4: 1799–1809.
7.
Pyeritz RE, Francke U. Conference report: the Second International Symposium on the Marfan Syndrome. Am J Med Genet . 1993; 47: 127–135.
8.
Greco GM, Ambrosino L. Treatment of retinal detachment in Marfan syndrome. Ann Ophthalmol . 1993; 25: 72–76.
9.
Mokri B. Spontaneous dissections of internal carotid arteries. Neurologist . 1997; 3: 104–119.
10.
Brandt T, Hausser I, Orberk E, et al. Ultrastructural connective tissue abnormalities in patients with spontaneous cervicocerebral artery dissections. Ann Neurol . 1998; 44: 281–285.

Information & Authors

Information

Published In

Neurology®
Volume 58Number 5March 12, 2002
Pages: 814-816
PubMed: 11889250

Publication History

Received: July 18, 2001
Accepted: November 16, 2001
Published online: March 12, 2002
Published in print: March 12, 2002

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Authors

Affiliations & Disclosures

Bahram Mokri, MD
From the Departments of Neurology (Dr. Mokri), Neurosurgery (Dr. Maher), and Radiology (Dr. Sencakova), Mayo Clinic, Rochester, MN.
Cormac O. Maher, MD
From the Departments of Neurology (Dr. Mokri), Neurosurgery (Dr. Maher), and Radiology (Dr. Sencakova), Mayo Clinic, Rochester, MN.
Drahomira Sencakova, MD
From the Departments of Neurology (Dr. Mokri), Neurosurgery (Dr. Maher), and Radiology (Dr. Sencakova), Mayo Clinic, Rochester, MN.

Notes

Address correspondence and reprint requests to Dr. Bahram Mokri, Mayo Clinic, Department of Neurology, 200 First Street SW, Rochester, MN 55905; e-mail: [email protected]

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