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March 12, 2002

Spontaneous CSF leaks: Underlying disorder of connective tissue

March 12, 2002 issue
58 (5) 814-816


Of 58 consecutive patients with spontaneous CSF leaks, nine exhibited features of connective tissue disorder. One had Marfan’s syndrome. Five additional patients had hyperflexible joints, of whom four had arachnodactyly, four were tall and slender, two had hyperextensible skin, and one had a strong family history of abdominal aorta aneurysms. Retinal detachment at a young age was noted in two. One patient had bilateral carotid dissections. A dural weakness may predispose patients to spontaneous CSF leak.

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Information & Authors


Published In

Volume 58Number 5March 12, 2002
Pages: 814-816
PubMed: 11889250

Publication History

Received: July 18, 2001
Accepted: November 16, 2001
Published online: March 12, 2002
Published in print: March 12, 2002


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Affiliations & Disclosures

Bahram Mokri, MD
From the Departments of Neurology (Dr. Mokri), Neurosurgery (Dr. Maher), and Radiology (Dr. Sencakova), Mayo Clinic, Rochester, MN.
Cormac O. Maher, MD
From the Departments of Neurology (Dr. Mokri), Neurosurgery (Dr. Maher), and Radiology (Dr. Sencakova), Mayo Clinic, Rochester, MN.
Drahomira Sencakova, MD
From the Departments of Neurology (Dr. Mokri), Neurosurgery (Dr. Maher), and Radiology (Dr. Sencakova), Mayo Clinic, Rochester, MN.


Address correspondence and reprint requests to Dr. Bahram Mokri, Mayo Clinic, Department of Neurology, 200 First Street SW, Rochester, MN 55905; e-mail: [email protected]

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