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September 19, 2017

Spontaneous periodic hypothermia in Parkinson disease with hypothalamic involvement

December 2017 issue
7 (6) 538-540

Abstract

An 88-year-old woman with history of atrial fibrillation, hypertension, and hypothyroidism was hospitalized for repeated episodes of hypothermia over 4 years. Initial rare episodes of mild hypothermia and confusion in winter months progressed to more frequent and severe episodes. The patient was hospitalized at least 3 times at other facilities before presenting to our hospital with recurrent daily episodes. During these episodes, her body temperature dropped spontaneously, followed by confusion, dysarthria, bradycardia, hypercarbic respiratory failure, and hypoglycemia.

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REFERENCES

1.
Li BY, Lou M. Severe hypothermia in Parkinson's disease. CNS Neurosci Ther 2012;18:864–866.
2.
Hama K, Miwa H, Kondo T. Life-threatening hypothermia in Parkinson's disease. Mov Disord 2009;24:945–946.
3.
Kloos RT. Spontaneous periodic hypothermia. Medicine1995;74:268–280.
4.
Shapiro WR, Williams GH, Plum F. Spontaneous recurrent hypothermia accompanying agenesis of the corpus callosum. Brain 1969;92:423–436.
5.
Lipton JM, Clark WG. Neurotransmitters in temperature control. Annu Rev Physiol 1986;48:613–623.
6.
Cox B, Tha S. The role of dopamine and noradrenaline in temperature control of normal and reserpine-pretreated mice. J Pharm Pharmacol 1975;27:242–247.
7.
Snow AE, Horita A. The stress-dependent nature of apomorphine hyperthermia. Brain Res 1976;117:163–168.
8.
Idiaquez J, Kaufmann H, Soza M, Necochea C. Pure autonomic failure: Bradbury Eggleston syndrome: case report [in Spanish]. Rev Med Chil 2005;133:215–218.

Information & Authors

Information

Published In

Neurology® Clinical Practice
Volume 7Number 6December 2017
Pages: 538-540

Publication History

Received: January 3, 2017
Accepted: July 5, 2017
Published online: September 19, 2017
Published in print: December 2017

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Disclosures

V. Renga and W.F. Hickey report no disclosures. J.L. Bernat serves on the editorial boards of Neurology® Clinical Practice, Neurocritical Care, Neurology Today®, The Physician's Index for Ethics and Medicine, and Multiple Sclerosis and Related Diseases; receives publishing royalties for Ethical and Legal Issues in Neurology (Elsevier, 2013), Ethical Issues in Neurology, 3rd ed. (Lippincott Williams & Wilkins, 2008), and Palliative Care in Neurology (Oxford University Press, 2004); and receives research support from NIH. Full disclosure form information provided by the authors is available with the full text of this article at Neurology.org/cp.

Study Funding

No targeted funding reported.

Authors

Affiliations & Disclosures

Vijay Renga, MD
Departments of Neurology (VR, JLB) and Pathology (WFH), Dartmouth-Hitchcock Medical Center & Geisel School of Medicine at Dartmouth, Lebanon, NH.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NONE
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
William F. Hickey, MD
Departments of Neurology (VR, JLB) and Pathology (WFH), Dartmouth-Hitchcock Medical Center & Geisel School of Medicine at Dartmouth, Lebanon, NH.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NONE
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
James L. Bernat, MD
Departments of Neurology (VR, JLB) and Pathology (WFH), Dartmouth-Hitchcock Medical Center & Geisel School of Medicine at Dartmouth, Lebanon, NH.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
Editorial Board: Neurocritical Care: 2002-present (no compensation) Editorial Board: Neurology Today: 2001-2017(no compensation) Editorial Board: The Physician's Index for Ethics and Medicine: 2011-present (compensation) Editorial Board: Multiple Sclerosis and Related Diseases: 2011-present (no compensation) Editorial Board: Neurology Clinical Practice (no compensation)
Patents:
1.
NONE
Publishing Royalties:
1.
Ethical and Legal Issues in Neurology. Elsevier, 2013 Ethical Issues in Neuorology, 3rd ed. Lippincott Williams & Wilkins, 2008. Palliative Care in Neurology. Oxford University Press, 2004.
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NIH Director, Ethics Core of SYNERGY: The Dartmouth Clinical and Translational Science Institute. National Center for Advancing Translational Sciences (NIH NCATS) UL1TR001086. (10% salary provision)
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE

Notes

Correspondence to: [email protected]
Funding information and disclosures are provided at the end of the article. Full disclosure form information provided by the authors is available with the full text of this article at Neurology.org/cp.

Author Contributions

V. Renga and J.L. Bernat were equally involved in writing the manuscript. W.F. Hickey prepared and interpreted the pathology slides and wrote the description of the pathology findings.

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Cited By
  1. Effects of Medications on Heat Loss Capacity in Chronic Disease Patients: Health Implications Amidst Global Warming, Pharmacological Reviews, 75, 6, (1140-1166), (2023).https://doi.org/10.1124/pharmrev.122.000782
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  2. A new perspective of hypothalamic disease: Shapiro's syndrome, Frontiers in Neurology, 13, (2022).https://doi.org/10.3389/fneur.2022.911332
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  3. Episodic headache with spontaneous hypothermia reveal Shapiro’s syndrome variant with effectiveness of clonidine therapy, The Journal of Headache and Pain, 22, 1, (2021).https://doi.org/10.1186/s10194-021-01245-3
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  4. A Pragmatic Approach to the Perioperative Management of Parkinson’s Disease, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 48, 3, (299-307), (2020).https://doi.org/10.1017/cjn.2020.211
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  5. Céphalées et hypothermies périodiques spontanées (syndrome de Shapiro) au cours de la maladie de Parkinson, La Revue de Médecine Interne, 41, (A215-A216), (2020).https://doi.org/10.1016/j.revmed.2020.10.371
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  6. Cold Shock Induced Protein RBM3 but Not Mild Hypothermia Protects Human SH-SY5Y Neuroblastoma Cells From MPP+-Induced Neurotoxicity, Frontiers in Neuroscience, 12, (2018).https://doi.org/10.3389/fnins.2018.00298
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