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December 9, 2015

Milk consumption and the risk of nigral degeneration

February 9, 2016 issue
86 (6) 496-497

Abstract

In the era of genetic research for neurodegenerative diseases, less attention has been paid to epidemiologists' search for potential environmental risk factors for Parkinson disease (PD). Epidemiologic evidence suggests that cigarette smoking is associated with about 50% lower risk of PD1 and exposure to certain pesticides such as rotenone and paraquat is associated with doubled risk.2 Recent studies also suggest that higher concentration of serum urate, an endogenous antioxidant, is associated with a lower risk of PD.3 Compared with these observations, another epidemiologic finding has been largely neglected. Several prospective studies,4–7 including the Honolulu-Asia Aging Study (HAAS),6 have reported that higher consumption of dairy products, or milk alone, was associated with higher risk for PD.

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REFERENCES

1.
Chen H, Huang X, Guo X, et al. Smoking duration, intensity, and risk of Parkinson disease. Neurology 2010;74:878–884.
2.
Tanner CM, Kamel F, Ross GW, et al. Rotenone, paraquat, and Parkinson's disease. Environ Health Perspect 2011;119:866–872.
3.
Weisskopf M, O'Reilly E, Chen H, Schwarzschild M, Ascherio A. Plasma urate and risk of Parkinson's disease. Am J Epidemiol 2007;166:561–567.
4.
Chen H, O'Reilly E, McCullough ML, et al. Consumption of dairy products and risk of Parkinson's disease. Am J Epidemiol 2007;165:998–1006.
5.
Chen H, Zhang SM, Hernan MA, Willett WC, Ascherio A. Diet and Parkinson's disease: a potential role of dairy products in men. Ann Neurol 2002;52:793–801.
6.
Park M, Ross GW, Petrovitch H, et al. Consumption of milk and calcium in midlife and the future risk of Parkinson disease. Neurology 2005;64:1047–1051.
7.
Kyrozis A, Ghika A, Stathopoulos P, Vassilopoulos D, Trichopoulos D, Trichopoulou A. Dietary and lifestyle variables in relation to incidence of Parkinson's disease in Greece. Eur J Epidemiol 2013;28:67–77.
8.
Abbott RD, Ross GW, Petrovitch H, et al. Midlife milk consumption and substantia nigra neuron density at death. Neurology 2016;86:512–519.
9.
Smith RJ. Hawaiian milk contamination creates alarm: a sour response by state regulators. Science 1982;217:137–140.
10.
Choi HK, Liu S, Curhan G. Intake of purine-rich foods, protein, and dairy products and relationship to serum levels of uric acid: the Third National Health and Nutrition Examination Survey. Arthritis Rheum 2005;52:283–289.

Information & Authors

Information

Published In

Neurology®
Volume 86Number 6February 9, 2016
Pages: 496-497
PubMed: 26658908

Publication History

Published online: December 9, 2015
Published in print: February 9, 2016

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Disclosure

Dr. Chen is supported by the Intramural Research Program of the NIH, the National Institute of Environmental Health Sciences. He serves on the editorial boards of the American Journal of Epidemiology, International Journal of Molecular Epidemiology and Genetics, and the American Journal of Neurodegenerative Disease. Dr. Marder receives research support from the NIH 1UL1 RR024156-01 (Director PCIR), PO412196-G (Co-I), the Parkinson Disease Foundation, Huntington's Disease Society of America, the Parkinson Study Group, CHDI, the Michael J. Fox Foundation, and TEVA. She received compensation for participating on the steering committee for U01NS052592. Go to Neurology.org for full disclosures.

Study Funding

No targeted funding reported.

Authors

Affiliations & Disclosures

Honglei Chen, MD, PhD
From the Epidemiology Branch (H.C.), National Institute of Environmental Health Sciences, Research Triangle Park, NC; and the Department of Neurology (K.M.), College of Physicians and Surgeons, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
2009- International Journal of Molecular Epidemiology and Genetics 2010- American Journal of Epidemiology 2012- American Journal of Neurodegenerative Disease
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NIH intramural funding (Z01-ES-101986) Principal Investigator 2007-current
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
Karen Marder, MD, MPH
From the Epidemiology Branch (H.C.), National Institute of Environmental Health Sciences, Research Triangle Park, NC; and the Department of Neurology (K.M.), College of Physicians and Surgeons, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY.
Disclosure
Scientific Advisory Boards:
1.
Raptor Pharmaceuticals Inc. - member of scientific advisory board
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
Commercial -Pfizer- travel and speaker honorarium Commercial -Raptor- travel to SAB meeting
Editorial Boards:
1.
Section editor, Current Neurology and Neuroscience
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
Research support - Teva PRIDE HD study
Research Support, Government Entities:
1.
NS036630(PI), 2UL1 RR024156-03(Director PCIR), 1U10NS077267-03 (CoPI),1R01NS073671-02(coI), 5R01N40068-10 (co-I),3U01AT000613-08 (coI) U01NS052592-05 (Co- I),5P20HG005535-02 (coI),5P50AG08702-24(coI), 5R01NS060113-03
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
Parkinson Disease Foundation (investigator), Huntington's Disease Society of America (investigator), Parkinson Study Group (Co-chair, executive committee) Michael J Fox foundation, CHDI (investigator) CHDI
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE

Notes

Correspondence to Dr. Chen: [email protected]
Go to Neurology.org for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the editorial.

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Cited By
  1. Role of Nutraceuticals and Physical Activity in Parkinson's Disease Risk and Lifestyle Management, Current Aging Science, 16, 3, (170-187), (2023).https://doi.org/10.2174/1874609816666230515121717
    Crossref
  2. Milk consumption and multiple health outcomes: umbrella review of systematic reviews and meta-analyses in humans, Nutrition & Metabolism, 18, 1, (2021).https://doi.org/10.1186/s12986-020-00527-y
    Crossref
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