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Editorial
December 28, 2016

Understanding of the role of manganese in parkinsonism and Parkinson disease

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January 24, 2017 issue
88 (4) 338-339

Abstract

Paracelsus is famous for saying “Poison is in everything, and no thing is without poison. The dosage makes it either a poison or a remedy.” The report in this issue of Neurology® by Racette et al.1 titled “Dose-dependent progression of parkinsonism in manganese-exposed welders” provides evidence for a dose-response relationship between ongoing exposure to this neurotoxic heavy metal—which also plays an important role in the function of the antioxidant enzyme superoxide dismutase—and progression of parkinsonian symptoms.

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REFERENCES

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Racette BA, Searles Nielsen S, Criswell SR, et al. Dose-dependent progression of parkinsonism in manganese-exposed welders. Neurology 2017;88:344–351.
2.
Mena I, Marin O, Fuenzalida S, Cotzias GC. Chronic manganese poisoning: clinical picture and manganese turnover. Neurology 1967;17:128–136.
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Sanotsky Y, Lesyk R, Fedoryshyn L, Komnatska I, Matviyenko Y, Fahn S. Manganic encephalopathy due to “ephedrone” abuse. Mov Disord 2007;22:1337–1343.
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Yamada M, Ohno S, Okayasu I, et al. Chronic manganese poisoning: a neuropathological study with determination of manganese distribution in the brain. Acta Neuropathol 1986;70:273–278.
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Eriksson H, Mägiste K, Plantin LO, et al. Effects of manganese oxide on monkeys as revealed by a combined neurochemical, histological and neurophysiological evaluation. Arch Toxicol 1987;61:46–52.
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Guilarte TR, Chen MK, McGlothan JL, et al. Nigrostriatal dopamine system dysfunction and subtle motor deficits in manganese-exposed non-human primates. Exp Neurol 2006;202:381–390.
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Guilarte TR, Burton NC, McGlothan JL, et al. Impairment of nigrostriatal dopamine neurotransmission by manganese is mediated by pre-synaptic mechanism(s): implications to manganese-induced parkinsonism. J Neurochem 2008;107:1236–1247.
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Erikson KM, Aschner M. Increased manganese uptake by primary astrocyte cultures with altered iron status is mediated primarily by divalent metal transporter. Neurotoxicology 2006;27:125–130.
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Zhang H, Gilbert ER, Pan S, et al. Dietary iron concentration influences serum concentrations of manganese in rats consuming organic or inorganic sources of manganese. Br J Nutr 2016;115:585–593.
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Segura-Aguilar J, Lind C. On the mechanism of the Mn3(+)-induced neurotoxicity of dopamine: prevention of quinone-derived oxygen toxicity by DT diaphorase and superoxide dismutase. Chem Biol Interact 1989;72:309–324.
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Lucchini R, Apostoli P, Perrone C, et al. Long-term exposure to “low levels” of manganese oxides and neurofunctional changes in ferroalloy workers. Neurotoxicology 1999;20:287–297.
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Information & Authors

Information

Published In

Neurology®
Volume 88Number 4January 24, 2017
Pages: 338-339
PubMed: 28031391

Publication History

Published online: December 28, 2016
Published in print: January 24, 2017

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Disclosure

The authors report no disclosures relevant to the manuscript. Go to Neurology.org for full disclosures.

Study Funding

No targeted funding reported.

Authors

Affiliations & Disclosures

Marcia H. Ratner, PhD
From the Laboratory of Molecular Neurobiology (M.H.R.), Department of Pharmacology & Experimental Therapeutics, Boston University School of Medicine, MA; and Department of Environmental Health Sciences (E.F.), School of Public Health, University at Albany, Rensselaer, NY.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
(1) Editorial Board Member, EC Pharmacology and Toxicology 2016
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NONE
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
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NONE
Edward Fitzgerald, PhD
From the Laboratory of Molecular Neurobiology (M.H.R.), Department of Pharmacology & Experimental Therapeutics, Boston University School of Medicine, MA; and Department of Environmental Health Sciences (E.F.), School of Public Health, University at Albany, Rensselaer, NY.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
National Institute of Environmental Health Sciences, R01ES022652, PI, 2014 - 2017
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE

Notes

Correspondence to Dr. Ratner: [email protected]
Go to Neurology.org for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.

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Cited By
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  2. Research on identification of ink marks based on machine learning and laser-induced breakdown spectroscopy, Journal of Laser Applications, 35, 1, (2023).https://doi.org/10.2351/7.0000895
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  3. Sesamol alleviates manganese-induced neuroinflammation and cognitive impairment via regulating the microglial cGAS-STING/NF-κB pathway, Environmental Pollution, 319, (120988), (2023).https://doi.org/10.1016/j.envpol.2022.120988
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  4. An Overview of the Relationship Between Occupational Manganese Exposure and Parkinsonism, Cureus, (2022).https://doi.org/10.7759/cureus.32161
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  5. Modelling Parkinson's Disease in C. elegans : Strengths and Limitations , Current Pharmaceutical Design, 28, 37, (3033-3048), (2022).https://doi.org/10.2174/1381612828666220915103502
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  6. AUTONOMIC DYSFUNCTION IN A WELDER FOLLOWING MANGANESE TOXICITY: A CASE REPORT, Eastern Ukrainian Medical Journal, 10, 4, (318-321), (2022).https://doi.org/10.21272/eumj.2022;10(4):318-321
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  7. Clinical evaluation and differential diagnosis of neurotoxic disease, Occupational Neurotoxicology, (47-75), (2022).https://doi.org/10.1016/bs.ant.2022.05.003
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  8. Parkinson’s Disease and the Metal–Microbiome–Gut–Brain Axis: A Systems Toxicology Approach, Antioxidants, 11, 1, (71), (2021).https://doi.org/10.3390/antiox11010071
    Crossref
  9. Metal Exposure and SNCA rs356219 Polymorphism Associated With Parkinson Disease and Parkinsonism, Frontiers in Neurology, 11, (2020).https://doi.org/10.3389/fneur.2020.556337
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  10. The role of iron in Parkinson's disease monkeys assessed by susceptibility weighted imaging and inductively coupled plasma mass spectrometry, Life Sciences, 240, (117091), (2020).https://doi.org/10.1016/j.lfs.2019.117091
    Crossref
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