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Clinical/Scientific Notes

January 17, 2011

Progressive encephalomyelitis with rigidity and myoclonus: Resolution after thymectomy

K. Clerinx, MD, T. Breban, MD, M. Schrooten, MD, M.I. Leite, MD, DPhil, A. Vincent, FRCPath, J. Verschakelen, MD, PhD, T. Tousseyn, MD, PhD, and W. Vandenberghe, MD, PhDAuthors Info & Affiliations

January 18, 2011 issue

76 (3) 303-304

https://doi.org/10.1212/WNL.0b013e318207b008

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Meinck H-M, Thompson PD. Stiff man syndrome and related conditions. Mov Disord 2002; 17: 853–866.

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Brown P, Marsden CD. The stiff man and stiff man plus syndromes. J Neurol 1999; 246: 648–652.

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Molina JA, Porta J, Garcia-Morales I, Bermejo PF, Jiménez-Jiménez FJ. Treatment with intravenous prednisone and immunoglobulin in a case of progressive encephalomyelitis with rigidity. J Neurol Neurosurg Psychiatry 2000; 68: 395–396.

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Hutchinson M, Waters P, McHugh J, et al. Progressive encephalomyelitis, rigidity, and myoclonus: a novel glycine receptor antibody. Neurology 2008; 71: 1291–1292.

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Brown P, Rothwell JC, Thompson PD, Britton TC, Day BL, Marsden CD. The hyperekplexias and their relationship to the normal startle reflex. Brain 1991; 114: 1903–1928.

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Ishii A, Hayashi A, Ohkoshi N, Matsuno S, Shoji S. Progressive encephalomyelitis with rigidity associated with anti-amphiphysin antibodies. J Neurol Neurosurg Psychiatry 2004; 75: 661–662.

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Vincent A, Leite MI, Waters P, Jacobi C, Becker CM, Meinck HM. Glycine receptor antibodies in progressive encephalomyelitis with rigidity and myoclonus, hyperekplexia and stiff person syndrome. Ann Neurol 2009; 66 (suppl 13): S50 Abstract.

Information & Authors

Information

Published In

Neurology^®

Volume 76 • Number 3 • January 18, 2011

Pages: 303-304

PubMed: 21242500

Copyright

Copyright © 2011 by AAN Enterprises, Inc.

Publication History

Received: March 9, 2010

Accepted: July 28, 2010

Published online: January 17, 2011

Published in print: January 18, 2011

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Funding Information

Disclosure: Dr. Clerinx, Dr. Breban, and Dr. Schrooten report no disclosures. Dr. Leite receives research support from the Oxford Biomedical Research Centre, the National Commissioning Group, and the Sir Halley Stewart Trust, UK. Dr. Vincent has served on scientific advisory boards for the Patrick Berthoud Trust and the Myasthenia Gravis Foundation of America; has received funding for travel and a speaker honorarium from Baxter International Inc.; serves as an Associate Editor for Brain; receives royalties from the publication of Clinical Neuroimmunology (Blackwell Publishing, 2005); receives research support from the European Union, NIHR Biomedical Research Centre Oxford, and Sir Halley Stewart Trust; and has received Musk antibody royalties and consulting fees from Athena Diagnostics, Inc., and Musk antibody royalties from RSR Ltd., Cardiff, UK. The University of Oxford, where A.V. is based, receives royalties and payments for antibody assays in neurologic diseases. Dr. Verschakelen, Dr. Tousseyn, and Dr. Vandenberghe report no disclosures.

Authors

Affiliations & Disclosures

K. Clerinx, MD

From the Departments of Neurology (K.C., T.B., M.S., W.V.), Radiology (J.V.), and Pathology (T.T.), University Hospitals Leuven, Leuven, Belgium; and Department of Clinical Neurology (M.I.L., A.V.), University of Oxford, Oxford, UK.

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T. Breban, MD

From the Departments of Neurology (K.C., T.B., M.S., W.V.), Radiology (J.V.), and Pathology (T.T.), University Hospitals Leuven, Leuven, Belgium; and Department of Clinical Neurology (M.I.L., A.V.), University of Oxford, Oxford, UK.

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M. Schrooten, MD

From the Departments of Neurology (K.C., T.B., M.S., W.V.), Radiology (J.V.), and Pathology (T.T.), University Hospitals Leuven, Leuven, Belgium; and Department of Clinical Neurology (M.I.L., A.V.), University of Oxford, Oxford, UK.

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M.I. Leite, MD, DPhil

From the Departments of Neurology (K.C., T.B., M.S., W.V.), Radiology (J.V.), and Pathology (T.T.), University Hospitals Leuven, Leuven, Belgium; and Department of Clinical Neurology (M.I.L., A.V.), University of Oxford, Oxford, UK.

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A. Vincent, FRCPath

From the Departments of Neurology (K.C., T.B., M.S., W.V.), Radiology (J.V.), and Pathology (T.T.), University Hospitals Leuven, Leuven, Belgium; and Department of Clinical Neurology (M.I.L., A.V.), University of Oxford, Oxford, UK.

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J. Verschakelen, MD, PhD

From the Departments of Neurology (K.C., T.B., M.S., W.V.), Radiology (J.V.), and Pathology (T.T.), University Hospitals Leuven, Leuven, Belgium; and Department of Clinical Neurology (M.I.L., A.V.), University of Oxford, Oxford, UK.

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T. Tousseyn, MD, PhD

From the Departments of Neurology (K.C., T.B., M.S., W.V.), Radiology (J.V.), and Pathology (T.T.), University Hospitals Leuven, Leuven, Belgium; and Department of Clinical Neurology (M.I.L., A.V.), University of Oxford, Oxford, UK.

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W. Vandenberghe, MD, PhD

From the Departments of Neurology (K.C., T.B., M.S., W.V.), Radiology (J.V.), and Pathology (T.T.), University Hospitals Leuven, Leuven, Belgium; and Department of Clinical Neurology (M.I.L., A.V.), University of Oxford, Oxford, UK.

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Notes

Address correspondence and reprint requests to Dr. Wim Vandenberghe, Department of Neurology, University Hospital Leuven, Herestraat 49, 3000 Leuven, Belgium; [email protected]

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Topics

Autoimmune diseases Class IV Immunology Level of Evidence Classification Movement Disorders Myoclonus Oncology Paraneoplastic syndrome Stiff person syndrome

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