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February 2, 2011

TRPV4 neuropathies
Calcium channel inhibition as a therapeutic target?

March 8, 2011 issue
76 (10) 856-857

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REFERENCES

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Auer-Grumbach M, Olschewski A, Papic L, et al. Alterations in the ankyrin domain of TRPV4 cause congenital distal SMA, scapuloperoneal SMA and HMSN2C. Nat Genet 2010;42:160–164.
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Deng HX, Klein CJ, Yan J, et al. Scapuloperoneal spinal muscular atrophy and CMT2C are allelic disorders caused by alterations in TRPV4. Nat Genet 2010;42:165–169.
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Landoure G, Zdebik AA, Martinez TL, et al. Mutations in TRPV4 cause Charcot-Marie-Tooth disease type 2C. Nat Genet 2010;42:170–174.
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Nilius B, Owsianik G. Channelopathies converge on TRPV4. Nat Genet 2010;42:98–100.
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Zimon M, Baets J, Auer-Grumbach M, et al. Dominant mutations in the cation channel gene transient receptor potential vanilloid 4 cause an unusual spectrum of neuropathies. Brain 2010;133:1798–1809.
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Rock MJ, Prenen J, Funari VA, et al. Gain-of-function mutations in TRPV4 cause autosomal dominant brachyolmia. Nat Genet 2008;40:999–1003.
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Dai J, Kim OH, Cho TJ, et al. Novel and recurrent TRPV4 mutations and their association with distinct phenotypes within the TRPV4 dysplasia family. J Med Genet 2010;47:704–709.
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Chen DH, Sul Y, Weiss M, et al. CMT2C with vocal cord paresis associated with short stature and mutations in the TRPV4 gene. Neurology 2010;75:1968–1975.
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Klein CJ, Shi Y, Fecto F, et al. TRPV4 mutations and cytotoxic hypercalcemia in axonal Charcot-Marie-Tooth neuropathies. Neurology 2011;76:887–894.
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Everaerts W, Zhen X, Ghosh D, et al. Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis. Proc Natl Acad Sci USA 2010;107:19084–19089.

Information & Authors

Information

Published In

Neurology®
Volume 76Number 10March 8, 2011
Pages: 856-857

Publication History

Published online: February 2, 2011
Published in print: March 8, 2011

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Authors

Affiliations & Disclosures

Jonathan Baets, MD
From the Neurogenetics Group, VIB Department of Molecular Genetics, and Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerpen; and Division of Neurology, University Hospital Antwerpen (UZA), Antwerpen, Belgium.
Peter De Jonghe, MD, PhD
From the Neurogenetics Group, VIB Department of Molecular Genetics, and Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerpen; and Division of Neurology, University Hospital Antwerpen (UZA), Antwerpen, Belgium.

Notes

Address correspondence and reprint requests to Dr. Jonathan Baets, Neurogenetics Group, VIB–Department of Molecular Genetics, University of Antwerp, Universiteitsplein 1, B-2610 Antwerpen, Belgium [email protected]

Funding Information

Disclosure: The authors report no disclosures

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Cited By
  1. TRPV4 plays an important role in rat prefrontal cortex changes induced by acute hypoxic exercise, Saudi Journal of Biological Sciences, 26, 6, (1194-1206), (2019).https://doi.org/10.1016/j.sjbs.2019.06.001
    Crossref
  2. The puzzle of TRPV4 channelopathies, EMBO reports, 14, 2, (152-163), (2013).https://doi.org/10.1038/embor.2012.219
    Crossref
  3. Dominant Charcot–Marie–Tooth syndrome and cognate disorders, Peripheral Nerve Disorders, (817-845), (2013).https://doi.org/10.1016/B978-0-444-52902-2.00047-3
    Crossref
  4. TRPV4 axonal neuropathy spectrum disorder, Journal of Clinical Neuroscience, 19, 7, (927-933), (2012).https://doi.org/10.1016/j.jocn.2011.12.003
    Crossref
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