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August 2, 2013

Delaying dementia
Can antihypertensives prevent Alzheimer dementia?

September 3, 2013 issue
81 (10) 860-862

Abstract

Oliver Wendell Holmes, Sr., a 19th-century physician, Dean of Harvard Medical School, and poet, described an enchanting thought experiment in his poem, “The Deacon's Wonderful One-Hoss Shay.” This carriage was crafted to be equally strong in every part, letting it run in perfect condition for 100 years before, one fine day, it disintegrated like a “bubble burst.” For many geriatric neurologists and their patients, that would be a worthy goal: to address all the “weak links,” the most vulnerable and fixable aspects of brain aging, thus compressing morbidity due to cognitive decline into a brief flicker prior to death. The emerging realization that dementia is a clinical syndrome with multiple etiologies lends urgency to the argument for a multipronged therapeutic approach more akin to that used in the prevention of coronary artery disease or stroke.

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Information & Authors

Information

Published In

Neurology®
Volume 81Number 10September 3, 2013
Pages: 860-862
PubMed: 23911755

Publication History

Published online: August 2, 2013
Published in print: September 3, 2013

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Disclosure

The author reports no disclosures relevant to the manuscript. Go to Neurology.org for full disclosures.

Study Funding

Supported by NIH/National Heart, Lung, and Blood Institute Contract (N01-HC-25195), the National Institute on Aging (R01 AG16495; AG08122), and the National Institute of Neurological Disorders and Stroke (R01 NS17950). The content is solely the responsibility of the authors and does not necessarily represent the official views of National Institute of Neurological Disorders and Stroke, NHLBI, NIA, or NIH.

Authors

Affiliations & Disclosures

Sudha Seshadri, MD
From Boston University School of Medicine, MA.
Disclosure
Scientific Advisory Boards:
1.
NONE
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
NONE
Editorial Boards:
1.
Journal of Alzheimer's Disease, Associate Editor since 2005. Stroke: Editorial Board since 2010. Neurology: Editorial Board since 2011.
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NIH/NIA: Grant number: R01 AG08122 (PI: Wolf, Seshadri); role: PI (Multiple PI grant) 08/01/10-07/31/15; NIH/NINDS: Grant number R01 NS017950-28 (Wolf); role: investigator; 07/01/09-6/31/14; NIH/NIA: 1 R01 AG033040-01 (PI: Wolf); role: investigator; 01/15/09-12/31/13; NIH/NIA: Grant number: R01 AG033193(PI: Seshadri); 02/01/09-01/31/13 NIH/NHLBI: R01HL093029(PI: Fornage)role PI of subcontract; 07/01/09-06/30/13. NIA/NIA: 5P30AG013846 (PI: Kowall) role:Investigator 01/07/97-6/30/2016
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
NONE
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE

Notes

Correspondence to Dr. Seshadri: [email protected]
Go to Neurology.org for full disclosures. Funding information and disclosures deemed relevant by the author, if any, are provided at the end of the editorial.

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Cited By
  1. Chronic pain in elderly patients, Medical alphabet, 3, (43-47), (2021).https://doi.org/10.33667/2078-5631-2021-3-43-47
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  2. Rationale and methods for a multicenter clinical trial assessing exercise and intensive vascular risk reduction in preventing dementia (rrAD Study), Contemporary Clinical Trials, 79, (44-54), (2019).https://doi.org/10.1016/j.cct.2019.02.007
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  3. Impact of Hypertension on Cognitive Function: A Scientific Statement From the American Heart Association, Hypertension, 68, 6, (2016).https://doi.org/10.1161/HYP.0000000000000053
    Crossref
  4. Preventing Dementia in Older Cardiovascular Patients, Current Cardiovascular Risk Reports, 8, 10, (2014).https://doi.org/10.1007/s12170-014-0401-x
    Crossref
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