Neglect after mesencephalic reticular formation lesions
Abstract
Discrete unilateral mesencephalic reticular formation lesions were made in four female stump-tailed macacques (Macaca speciosa). Control lesions of identical size were placed in the left medial dorsal thalamic nucleus, left ventral posterolateral thalamic nucleus, and left pontine nucleus. Experimental subjects showed profound tactile, visual and auditory neglect, in addition to ipsilateral hemispheric slowing on EEG. Controls did not demonstrate either phenomenon. This study suggests that neglect results from any lesion along the corticolimbic-reticular activating loop, and that the basis of neglect is a unilateral defect in the alerting response to sensory stimuli because of a disruption of this loop.
Get full access to this article
View all available purchase options and get full access to this article.
Information & Authors
Information
Published In
Copyright
© 1974 by the American Academy of Neurology.
Publication History
Published online: March 1, 1974
Published in print: March 1974
Authors
Metrics & Citations
Metrics
Citation information is sourced from Crossref Cited-by service.
Citations
Download Citations
If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Select your manager software from the list below and click Download.
Cited By
- Brain Network Dysfunction in Poststroke Delirium and Spatial Neglect: An fMRI Study, Stroke, 53, 3, (930-938), (2022).https://doi.org/10.1161/STROKEAHA.121.035733
- Functional connectome of arousal and motor brainstem nuclei in living humans by 7 Tesla resting-state fMRI, NeuroImage, 249, (118865), (2022).https://doi.org/10.1016/j.neuroimage.2021.118865
- Négligences unilatérales ou agnosies spatiales unilatérales, Traité Pratique de Neuropsychologie Clinique de L'adulte, (315-338), (2021).https://doi.org/10.1016/B978-2-294-76689-3.00012-7
- Using machine learning-based lesion behavior mapping to identify anatomical networks of cognitive dysfunction: Spatial neglect and attention, NeuroImage, 201, (116000), (2019).https://doi.org/10.1016/j.neuroimage.2019.07.013
- Bottom-up gamma maintenance in various disorders, Neurobiology of Disease, 128, (31-39), (2019).https://doi.org/10.1016/j.nbd.2018.01.010
- Ventral attention and motor network connectivity is relevant to functional impairment in spatial neglect after right brain stroke, Brain and Cognition, 129, (16-24), (2019).https://doi.org/10.1016/j.bandc.2018.11.013
- Arousal and movement disorders, Arousal in Neurological and Psychiatric Diseases, (179-193), (2019).https://doi.org/10.1016/B978-0-12-817992-5.00011-8
- Physiology of arousal, Arousal in Neurological and Psychiatric Diseases, (25-42), (2019).https://doi.org/10.1016/B978-0-12-817992-5.00002-7
- Physiological Mechanisms for the Control of Waking, The Behavioral, Molecular, Pharmacological, and Clinical Basis of the Sleep-Wake Cycle, (27-43), (2019).https://doi.org/10.1016/B978-0-12-816430-3.00003-8
- Bottom‐up gamma and bipolar disorder, clinical and neuroepigenetic implications, Bipolar Disorders, 21, 2, (108-116), (2018).https://doi.org/10.1111/bdi.12735
- See more
Loading...
View Options
Login options
Check if you have access through your login credentials or your institution to get full access on this article.
Personal login Institutional LoginPurchase Options
The neurology.org payment platform is currently offline. Our technical team is working as quickly as possible to restore service.
If you need immediate support or to place an order, please call or email customer service:
- 1-800-638-3030 for U.S. customers - 8:30 - 7 pm ET (M-F)
- 1-301-223-2300 for customers outside the U.S. - 8:30 - 7 pm ET (M-F)
- [email protected]
We appreciate your patience during this time and apologize for any inconvenience.