Skip to main content
AAN.com

Abstract

Industrial overexposure to chlordecone, an organochlorine insecticide, caused tremor in 76 of 148 exposed workers. Chlordecone was absorbed through oral, respiratory, and dermal routes, the last possibly the most significant. Epidemiology of this incident disclosed low-level, wide spread environmental exposure of man to chlordecone. In 23 workers with chronic chlordecone intoxication, tremor was associated with opsoclonus, pleuritic pain and arthralgia. No seizures were reported. The site of action of chlordecone on the central nervous system is unknown. It concentrates inhuman adipose and hepatic tissue but is not biodegradable, either in humans or elsewhere in nature.

Get full access to this article

View all available purchase options and get full access to this article.

Information & Authors

Information

Published In

Neurology®
Volume 28Number 7July 1978
Pages: 626
PubMed: 79155

Publication History

Published online: July 1, 1978
Published in print: July 1978

Permissions

Request permissions for this article.

Authors

Affiliations & Disclosures

JOHN R. TAYLOR, M.D.
Department of Neurology (Drs. Taylor, Selhorst, and Houff) and the Division of Neuropathology (Dr. Martinez), Medical College of Virginia, Richmond, Virginia.
JOHN B. SELHORST, M.D.
Department of Neurology (Drs. Taylor, Selhorst, and Houff) and the Division of Neuropathology (Dr. Martinez), Medical College of Virginia, Richmond, Virginia.
SIDNEY A. HOUFF, M.D.
Department of Neurology (Drs. Taylor, Selhorst, and Houff) and the Division of Neuropathology (Dr. Martinez), Medical College of Virginia, Richmond, Virginia.
A. JULIO MARTINEZ, M.D.
Department of Neurology (Drs. Taylor, Selhorst, and Houff) and the Division of Neuropathology (Dr. Martinez), Medical College of Virginia, Richmond, Virginia.

Metrics & Citations

Metrics

Citation information is sourced from Crossref Cited-by service.

Citations

Download Citations

If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Select your manager software from the list below and click Download.

Cited By
  1. The Pesticide Chlordecone Promotes Parkinsonism-like Neurodegeneration with Tau Lesions in Midbrain Cultures and C. elegans Worms, Cells, 12, 9, (1336), (2023).https://doi.org/10.3390/cells12091336
    Crossref
  2. Pesticides and tremor: An overview of association, mechanisms and confounders, Environmental Research, 229, (115442), (2023).https://doi.org/10.1016/j.envres.2023.115442
    Crossref
  3. Chlordecone: development of a physiologically based pharmacokinetic tool to support human health risks assessments, Archives of Toxicology, 96, 4, (1009-1019), (2022).https://doi.org/10.1007/s00204-022-03231-3
    Crossref
  4. Visual contrast sensitivity in school-age Guadeloupean children exposed to chlordecone, NeuroToxicology, 78, (195-201), (2020).https://doi.org/10.1016/j.neuro.2020.02.012
    Crossref
  5. PESTICIDES, Environmental Toxicants, (855-875), (2020).https://doi.org/10.1002/9781119438922.ch22
    Crossref
  6. Revue systématique de l’impact du chlordécone sur la santé humaine aux Antilles françaises, Therapies, 74, 6, (611-625), (2019).https://doi.org/10.1016/j.therap.2019.01.010
    Crossref
  7. Gestational exposure to chlordecone promotes transgenerational changes in the murine reproductive system of males, Scientific Reports, 8, 1, (2018).https://doi.org/10.1038/s41598-018-28670-w
    Crossref
  8. Chlordecone potentiates auto-immune hepatitis and promotes brain entry of MHV3 during viral hepatitis in mouse models, Toxicology Letters, 299, (129-136), (2018).https://doi.org/10.1016/j.toxlet.2018.09.014
    Crossref
  9. Organochlorine and Pyrethroid Insecticides, Comprehensive Toxicology, (242-258), (2018).https://doi.org/10.1016/B978-0-12-801238-3.65834-8
    Crossref
  10. Tremor essencial em guardas de endemias expostos a agrotóxicos: estudo caso-controle, Cadernos de Saúde Pública, 33, 8, (2017).https://doi.org/10.1590/0102-311x00194915
    Crossref
  11. See more
Loading...

View Options

Login options

Check if you have access through your login credentials or your institution to get full access on this article.

Personal login Institutional Login
Purchase Options

The neurology.org payment platform is currently offline. Our technical team is working as quickly as possible to restore service.

If you need immediate support or to place an order, please call or email customer service:

  • 1-800-638-3030 for U.S. customers - 8:30 - 7 pm ET (M-F)
  • 1-301-223-2300 for customers outside the U.S. - 8:30 - 7 pm ET (M-F)
  • [email protected]

We appreciate your patience during this time and apologize for any inconvenience.

View options

PDF and All Supplements

Download PDF and Supplementary Material

Full Text

View Full Text

Media

Figures

Other

Tables

Share

Share

Share article link

Share