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Abstract

Positron emission tomography was used to measure local cerebral glucose utilization by the 2-[18F]fluoro-2-deoxy-D-glucose technique in 23 patients with cerebral gliomas. All 10 high-grade (III and IV) astrocytomas demonstrated a region of high activity with a glucose consumption of 7.4 ± 3.5 (SD) mg/100 gm per minute. The 13 low-grade (I and II) gliomas had a glucose metabolic rate of 4.0 ± 1.8 mg/100 gm per minute, with no distinctly visible hot spot. Thus, we found a correlation between rate of glycolysis and malignancy in primary cerebral tumors. Cerebral cortical glucose utilization was often depressed in areas adjacent to or neurally connected to the tumor site, and there was focal irregular delta wave EEG activity in these areas.

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Published In

Neurology®
Volume 32Number 12December 1982
Pages: 1323
PubMed: 6983044

Publication History

Published online: December 1, 1982
Published in print: December 1982

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Giovanni Di Chiro, M.D.
Neuroradiology and Computed Tomography Section, Surgical Neurology Branch (Drs. Di Chiro, DeLaPaz, Brooks, and Patronas) and the Surgical Neurology Branch (Drs. Kornblith, Smith, and Kufta), National Institute of Neurological and Communicative Disorders and Stroke, the Laboratory of Cerebral Metabolism, National Institute of Mental Health (Dr. Sokoloff) and the Nuclear Medicine Department, Clinical Center (Drs. Kessler, Johnston, and Manning), National Institutes of Health, Bethesda, MD, and the Brookhaven National Laboratory, Division of Health and Environmental Research, Department of Energy (Dr. Wolf), Upton, NY.
Robert L. DeLaPaz, M.D.
Neuroradiology and Computed Tomography Section, Surgical Neurology Branch (Drs. Di Chiro, DeLaPaz, Brooks, and Patronas) and the Surgical Neurology Branch (Drs. Kornblith, Smith, and Kufta), National Institute of Neurological and Communicative Disorders and Stroke, the Laboratory of Cerebral Metabolism, National Institute of Mental Health (Dr. Sokoloff) and the Nuclear Medicine Department, Clinical Center (Drs. Kessler, Johnston, and Manning), National Institutes of Health, Bethesda, MD, and the Brookhaven National Laboratory, Division of Health and Environmental Research, Department of Energy (Dr. Wolf), Upton, NY.
Rodney A. Brooks, Ph.D.
Neuroradiology and Computed Tomography Section, Surgical Neurology Branch (Drs. Di Chiro, DeLaPaz, Brooks, and Patronas) and the Surgical Neurology Branch (Drs. Kornblith, Smith, and Kufta), National Institute of Neurological and Communicative Disorders and Stroke, the Laboratory of Cerebral Metabolism, National Institute of Mental Health (Dr. Sokoloff) and the Nuclear Medicine Department, Clinical Center (Drs. Kessler, Johnston, and Manning), National Institutes of Health, Bethesda, MD, and the Brookhaven National Laboratory, Division of Health and Environmental Research, Department of Energy (Dr. Wolf), Upton, NY.
Louis Sokoloff, M.D.
Neuroradiology and Computed Tomography Section, Surgical Neurology Branch (Drs. Di Chiro, DeLaPaz, Brooks, and Patronas) and the Surgical Neurology Branch (Drs. Kornblith, Smith, and Kufta), National Institute of Neurological and Communicative Disorders and Stroke, the Laboratory of Cerebral Metabolism, National Institute of Mental Health (Dr. Sokoloff) and the Nuclear Medicine Department, Clinical Center (Drs. Kessler, Johnston, and Manning), National Institutes of Health, Bethesda, MD, and the Brookhaven National Laboratory, Division of Health and Environmental Research, Department of Energy (Dr. Wolf), Upton, NY.
Paul L. Kornblith, M.D.
Neuroradiology and Computed Tomography Section, Surgical Neurology Branch (Drs. Di Chiro, DeLaPaz, Brooks, and Patronas) and the Surgical Neurology Branch (Drs. Kornblith, Smith, and Kufta), National Institute of Neurological and Communicative Disorders and Stroke, the Laboratory of Cerebral Metabolism, National Institute of Mental Health (Dr. Sokoloff) and the Nuclear Medicine Department, Clinical Center (Drs. Kessler, Johnston, and Manning), National Institutes of Health, Bethesda, MD, and the Brookhaven National Laboratory, Division of Health and Environmental Research, Department of Energy (Dr. Wolf), Upton, NY.
Barry H. Smith, M.D., Ph.D.
Neuroradiology and Computed Tomography Section, Surgical Neurology Branch (Drs. Di Chiro, DeLaPaz, Brooks, and Patronas) and the Surgical Neurology Branch (Drs. Kornblith, Smith, and Kufta), National Institute of Neurological and Communicative Disorders and Stroke, the Laboratory of Cerebral Metabolism, National Institute of Mental Health (Dr. Sokoloff) and the Nuclear Medicine Department, Clinical Center (Drs. Kessler, Johnston, and Manning), National Institutes of Health, Bethesda, MD, and the Brookhaven National Laboratory, Division of Health and Environmental Research, Department of Energy (Dr. Wolf), Upton, NY.
Nicholas J. Patronas, M.D.
Neuroradiology and Computed Tomography Section, Surgical Neurology Branch (Drs. Di Chiro, DeLaPaz, Brooks, and Patronas) and the Surgical Neurology Branch (Drs. Kornblith, Smith, and Kufta), National Institute of Neurological and Communicative Disorders and Stroke, the Laboratory of Cerebral Metabolism, National Institute of Mental Health (Dr. Sokoloff) and the Nuclear Medicine Department, Clinical Center (Drs. Kessler, Johnston, and Manning), National Institutes of Health, Bethesda, MD, and the Brookhaven National Laboratory, Division of Health and Environmental Research, Department of Energy (Dr. Wolf), Upton, NY.
Conrad V. Kufta, M.D.
Neuroradiology and Computed Tomography Section, Surgical Neurology Branch (Drs. Di Chiro, DeLaPaz, Brooks, and Patronas) and the Surgical Neurology Branch (Drs. Kornblith, Smith, and Kufta), National Institute of Neurological and Communicative Disorders and Stroke, the Laboratory of Cerebral Metabolism, National Institute of Mental Health (Dr. Sokoloff) and the Nuclear Medicine Department, Clinical Center (Drs. Kessler, Johnston, and Manning), National Institutes of Health, Bethesda, MD, and the Brookhaven National Laboratory, Division of Health and Environmental Research, Department of Energy (Dr. Wolf), Upton, NY.
Robert M. Kessler, M.D.
Neuroradiology and Computed Tomography Section, Surgical Neurology Branch (Drs. Di Chiro, DeLaPaz, Brooks, and Patronas) and the Surgical Neurology Branch (Drs. Kornblith, Smith, and Kufta), National Institute of Neurological and Communicative Disorders and Stroke, the Laboratory of Cerebral Metabolism, National Institute of Mental Health (Dr. Sokoloff) and the Nuclear Medicine Department, Clinical Center (Drs. Kessler, Johnston, and Manning), National Institutes of Health, Bethesda, MD, and the Brookhaven National Laboratory, Division of Health and Environmental Research, Department of Energy (Dr. Wolf), Upton, NY.
Gerald S. Johnston, M.D.
Neuroradiology and Computed Tomography Section, Surgical Neurology Branch (Drs. Di Chiro, DeLaPaz, Brooks, and Patronas) and the Surgical Neurology Branch (Drs. Kornblith, Smith, and Kufta), National Institute of Neurological and Communicative Disorders and Stroke, the Laboratory of Cerebral Metabolism, National Institute of Mental Health (Dr. Sokoloff) and the Nuclear Medicine Department, Clinical Center (Drs. Kessler, Johnston, and Manning), National Institutes of Health, Bethesda, MD, and the Brookhaven National Laboratory, Division of Health and Environmental Research, Department of Energy (Dr. Wolf), Upton, NY.
Ronald G. Manning, Ph.D.
Neuroradiology and Computed Tomography Section, Surgical Neurology Branch (Drs. Di Chiro, DeLaPaz, Brooks, and Patronas) and the Surgical Neurology Branch (Drs. Kornblith, Smith, and Kufta), National Institute of Neurological and Communicative Disorders and Stroke, the Laboratory of Cerebral Metabolism, National Institute of Mental Health (Dr. Sokoloff) and the Nuclear Medicine Department, Clinical Center (Drs. Kessler, Johnston, and Manning), National Institutes of Health, Bethesda, MD, and the Brookhaven National Laboratory, Division of Health and Environmental Research, Department of Energy (Dr. Wolf), Upton, NY.
Alfred P. Wolf, Ph.D.
Neuroradiology and Computed Tomography Section, Surgical Neurology Branch (Drs. Di Chiro, DeLaPaz, Brooks, and Patronas) and the Surgical Neurology Branch (Drs. Kornblith, Smith, and Kufta), National Institute of Neurological and Communicative Disorders and Stroke, the Laboratory of Cerebral Metabolism, National Institute of Mental Health (Dr. Sokoloff) and the Nuclear Medicine Department, Clinical Center (Drs. Kessler, Johnston, and Manning), National Institutes of Health, Bethesda, MD, and the Brookhaven National Laboratory, Division of Health and Environmental Research, Department of Energy (Dr. Wolf), Upton, NY.

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