Tardive dystonia
Late‐onset and persistent dystonia caused by antipsychotic drugs
Abstract
It is not widely recognized that antipsychotic drugs can cause late-onset and persistent dystonia. This dystonia, which we call tardive dystonia, is to be distinguished from acute dystonic reactions, which are transient, and from classic tardive dyskinesia, which is a choreic disorder that predominantly affects the oral region. We present 42 patients with tardive dystonia. The age of onset of dystonia was 13 to 60 years. Symptoms began after 3 days to 11 years of antipsychotic therapy. Younger patients tended to have more generalized dystonia. In a few patients, spontaneous remission occurred, but dystonia persisted for years in most. Therapy was rarely a complete success. The most frequently helpful medications were tetrabenazine (68% of patients improved) and anticholinergics (39% improved).
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Published In
Neurology®
Volume 32 • Number 12 • December 1982
Pages: 1335
Copyright
© 1982 by the American Academy of Neurology.
Publication History
Published online: December 1, 1982
Published in print: December 1982
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- “Clozapine & Valbenazine for Treatment of Tardive Cervical Dystonia: A Case Report”, Translation: The University of Toledo Journal of Medical Sciences, 11, 2, (2023).https://doi.org/10.46570/utjms.vol11-2023-526
- Tardive Syndrome Is a Mysterious Phenomenon with Different Clinical Manifestations—Review, Journal of Clinical Medicine, 12, 4, (1498), (2023).https://doi.org/10.3390/jcm12041498
- Treatment of tardive dystonia: A review, Dystonia, 2, (2023).https://doi.org/10.3389/dyst.2023.10957
- A Case of Tardive Dystonia with Task Specificity Confined to the Lower Extremities only during Walking, Progress in Rehabilitation Medicine, 8, 0, (n/a), (2023).https://doi.org/10.2490/prm.20230014
- A polymorphism in the dopamine receptor DRD5 is associated with blepharospasm, Neurology, 58, 1, (124-126), (2023)./doi/10.1212/WNL.58.1.124
- Bilateral deep brain stimulation of subthalamic nucleus alleviates tardive dystonia, Neurology, 66, 11, (1778-1779), (2023)./doi/10.1212/01.wnl.0000218300.38599.a0
- Isolated Cervical Dystonia: Diagnosis and Classification, Movement Disorders, (2023).https://doi.org/10.1002/mds.29387
- Predicting symptom response and engagement in a digital intervention among individuals with schizophrenia and related psychoses, Frontiers in Psychiatry, 13, (2022).https://doi.org/10.3389/fpsyt.2022.807116
- Recurrent Temporomandibular Joint Dislocation Due to Antiemetic Induced Acute Dystonia: A Case Report, Journal of Emergency Medicine Case Reports, 13, 2, (40-42), (2022).https://doi.org/10.33706/jemcr.1015430
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