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Abstract

A young woman presented with podophyllin intoxication following topical application of podophyllin resin to genital condylomata acuminata. The disorder was marked by hallucinatory psychosis, bone marrow depression, and mild hepatic dysfunction. The psychosis and systemic disturbances resolved within 3 weeks, but were followed by autonomic and sensorimotor peripheral neuropathy. This case illustrates the transient central neurotoxicity and persistent peripheral neurotoxicity of podophyllin.

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Published In

Neurology®
Volume 32Number 3March 1982
Pages: 308
PubMed: 7199647

Publication History

Published online: March 1, 1982
Published in print: March 1982

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Authors

Affiliations & Disclosures

Christopher M. Filley, M.D.
Department of Neurology (Drs. Filley, Graff-Radford, Lacy, and Earnest) and Department of Medicine (Dr. Heitner), Denver General Hospital and University of Colorado Health Sciences Center, Denver, CO.
Neill R. Graff-Radford, M.B., B.Ch., M.R.C.P. (UK)
Department of Neurology (Drs. Filley, Graff-Radford, Lacy, and Earnest) and Department of Medicine (Dr. Heitner), Denver General Hospital and University of Colorado Health Sciences Center, Denver, CO.
Joseph R. Lacy, M.D.
Department of Neurology (Drs. Filley, Graff-Radford, Lacy, and Earnest) and Department of Medicine (Dr. Heitner), Denver General Hospital and University of Colorado Health Sciences Center, Denver, CO.
Mark A. Heitner, M.D.
Department of Neurology (Drs. Filley, Graff-Radford, Lacy, and Earnest) and Department of Medicine (Dr. Heitner), Denver General Hospital and University of Colorado Health Sciences Center, Denver, CO.
Michael P. Earnest, M.D.
Department of Neurology (Drs. Filley, Graff-Radford, Lacy, and Earnest) and Department of Medicine (Dr. Heitner), Denver General Hospital and University of Colorado Health Sciences Center, Denver, CO.

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Cited By
  1. Fatal podophyllin poisoning with multi-organ toxicity: A case report, Journal of Pediatric Critical Care, 10, 5, (231), (2023).https://doi.org/10.4103/jpcc.jpcc_47_23
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  2. Podophyllin in dermatology: Revisiting a historical drug, Indian Dermatology Online Journal, 13, 1, (167), (2022).https://doi.org/10.4103/idoj.idoj_225_21
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  3. Chemistry and Biological Activities of Naturally Occurring and Structurally Modified Podophyllotoxins, Molecules, 28, 1, (302), (2022).https://doi.org/10.3390/molecules28010302
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  4. Sexually Transmitted Infections Treatment Guidelines, 2021, MMWR. Recommendations and Reports, 70, 4, (1-187), (2021).https://doi.org/10.15585/mmwr.rr7004a1
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  5. Metabolic map of the antiviral drug podophyllotoxin provides insights into hepatotoxicity, Xenobiotica, 51, 9, (1047-1059), (2021).https://doi.org/10.1080/00498254.2021.1961920
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  6. Giant Perianal Condyloma Successfully Treated with Podophyllin at 25% in Solid Petrolatum, Journal of Coloproctology, 41, 03, (289-294), (2021).https://doi.org/10.1055/s-0041-1732329
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  7. Bioactive Molecules of Endophytic Fungi and Their Potential in Anticancer Drug Development, Current Pharmacology Reports, 7, 2, (27-41), (2021).https://doi.org/10.1007/s40495-021-00251-y
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  8. A Rare Case of Podophyllin Poisoning: Early Intervention is Lifesaving, Indian Journal of Critical Care Medicine, 24, 6, (477-479), (2020).https://doi.org/10.5005/jp-journals-10071-23448
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  9. Infecciones cervicovaginales durante el embarazo: recomendaciones, EMC - Ginecología-Obstetricia, 55, 1, (1-11), (2019).https://doi.org/10.1016/S1283-081X(19)41711-6
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  10. Dangerous plants in dermatology: Legal and controlled, Clinics in Dermatology, 36, 3, (399-419), (2018).https://doi.org/10.1016/j.clindermatol.2018.03.013
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