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Abstract

No uniformly accepted hypothesis explains the genesis and rupture of intracranial aneurysms. We followed 5,184 men and women prospectively for 26 years; 36 cases of aneurysmal subarachnoid hemorrhage (SAH) accounted for 62% of all intracranial hemorrhages. Blood pressure before SAH was higher in these patients than in controls. Definite hypertension (2160 mm Hg and/or 295 mm Hg) at entry to the study or at closest exam before SAH was more frequent than in controls. Cigarette smoking, particularly heavy smoking, was also more frequent among cases.

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Published In

Neurology®
Volume 34Number 7July 1984
Pages: 847

Publication History

Published online: July 1, 1984
Published in print: July 1984

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Ralph L. Sacco, MD
From the Department of Neurology (Drs. Sacco, Wolf, Bharucha, and Palmer), the Section of Preventive Medicine and Epidemiology, the Evans Memorial Department of Clinical Research and Department of Medicine (Drs. Wolf and Kannel), University Hospital, Boston University School of Medicine; the Department of Statistics (Drs. Meeks and D'Agostino and Mr. Charette). Boston University, Boston, MA; and the Heart Disease Epidemiology Study (Miss McNamara), Division of Heart and Vascular Disease, National Heart, Lung, and Blood Institute, Bethesda, MD.
Philip A. Wolf, MD
From the Department of Neurology (Drs. Sacco, Wolf, Bharucha, and Palmer), the Section of Preventive Medicine and Epidemiology, the Evans Memorial Department of Clinical Research and Department of Medicine (Drs. Wolf and Kannel), University Hospital, Boston University School of Medicine; the Department of Statistics (Drs. Meeks and D'Agostino and Mr. Charette). Boston University, Boston, MA; and the Heart Disease Epidemiology Study (Miss McNamara), Division of Heart and Vascular Disease, National Heart, Lung, and Blood Institute, Bethesda, MD.
Nadir E. Bharucha, MD
From the Department of Neurology (Drs. Sacco, Wolf, Bharucha, and Palmer), the Section of Preventive Medicine and Epidemiology, the Evans Memorial Department of Clinical Research and Department of Medicine (Drs. Wolf and Kannel), University Hospital, Boston University School of Medicine; the Department of Statistics (Drs. Meeks and D'Agostino and Mr. Charette). Boston University, Boston, MA; and the Heart Disease Epidemiology Study (Miss McNamara), Division of Heart and Vascular Disease, National Heart, Lung, and Blood Institute, Bethesda, MD.
Stephen L. Meeks, PhD
From the Department of Neurology (Drs. Sacco, Wolf, Bharucha, and Palmer), the Section of Preventive Medicine and Epidemiology, the Evans Memorial Department of Clinical Research and Department of Medicine (Drs. Wolf and Kannel), University Hospital, Boston University School of Medicine; the Department of Statistics (Drs. Meeks and D'Agostino and Mr. Charette). Boston University, Boston, MA; and the Heart Disease Epidemiology Study (Miss McNamara), Division of Heart and Vascular Disease, National Heart, Lung, and Blood Institute, Bethesda, MD.
William B. Kannel, MD
From the Department of Neurology (Drs. Sacco, Wolf, Bharucha, and Palmer), the Section of Preventive Medicine and Epidemiology, the Evans Memorial Department of Clinical Research and Department of Medicine (Drs. Wolf and Kannel), University Hospital, Boston University School of Medicine; the Department of Statistics (Drs. Meeks and D'Agostino and Mr. Charette). Boston University, Boston, MA; and the Heart Disease Epidemiology Study (Miss McNamara), Division of Heart and Vascular Disease, National Heart, Lung, and Blood Institute, Bethesda, MD.
L. Joseph Charette
From the Department of Neurology (Drs. Sacco, Wolf, Bharucha, and Palmer), the Section of Preventive Medicine and Epidemiology, the Evans Memorial Department of Clinical Research and Department of Medicine (Drs. Wolf and Kannel), University Hospital, Boston University School of Medicine; the Department of Statistics (Drs. Meeks and D'Agostino and Mr. Charette). Boston University, Boston, MA; and the Heart Disease Epidemiology Study (Miss McNamara), Division of Heart and Vascular Disease, National Heart, Lung, and Blood Institute, Bethesda, MD.
Patricia M. McNamara
From the Department of Neurology (Drs. Sacco, Wolf, Bharucha, and Palmer), the Section of Preventive Medicine and Epidemiology, the Evans Memorial Department of Clinical Research and Department of Medicine (Drs. Wolf and Kannel), University Hospital, Boston University School of Medicine; the Department of Statistics (Drs. Meeks and D'Agostino and Mr. Charette). Boston University, Boston, MA; and the Heart Disease Epidemiology Study (Miss McNamara), Division of Heart and Vascular Disease, National Heart, Lung, and Blood Institute, Bethesda, MD.
E. Prather Palmer, MD
From the Department of Neurology (Drs. Sacco, Wolf, Bharucha, and Palmer), the Section of Preventive Medicine and Epidemiology, the Evans Memorial Department of Clinical Research and Department of Medicine (Drs. Wolf and Kannel), University Hospital, Boston University School of Medicine; the Department of Statistics (Drs. Meeks and D'Agostino and Mr. Charette). Boston University, Boston, MA; and the Heart Disease Epidemiology Study (Miss McNamara), Division of Heart and Vascular Disease, National Heart, Lung, and Blood Institute, Bethesda, MD.
Ralph D'Agostino, PhD
From the Department of Neurology (Drs. Sacco, Wolf, Bharucha, and Palmer), the Section of Preventive Medicine and Epidemiology, the Evans Memorial Department of Clinical Research and Department of Medicine (Drs. Wolf and Kannel), University Hospital, Boston University School of Medicine; the Department of Statistics (Drs. Meeks and D'Agostino and Mr. Charette). Boston University, Boston, MA; and the Heart Disease Epidemiology Study (Miss McNamara), Division of Heart and Vascular Disease, National Heart, Lung, and Blood Institute, Bethesda, MD.

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