Clinical diagnosis of Alzheimer's disease
Report of the NINCDS‐ADRDA Work Group* under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
Abstract
Clinical criteria for the diagnosis of Alzheimer's disease include insidious onset and progressive impairment of memory and other cognitive functions. There are no motor, sensory, or coordination deficits early in the disease. The diagnosis cannot be determined by laboratory tests. These tests are important primarily in identifying other possible causes of dementia that must be excluded before the diagnosis of Alzheimer's disease may be made with confidence. Neuropsychological tests provide confirmatory evidence of the diagnosis of dementia and help to assess the course and response to therapy. The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information becomes available.
Get full access to this article
View all available purchase options and get full access to this article.
Information & Authors
Information
Published In
Copyright
© 1984 by the American Academy of Neurology.
Publication History
Published online: July 1, 1984
Published in print: July 1984
Authors
Metrics & Citations
Metrics
Citation information is sourced from Crossref Cited-by service.
Citations
Download Citations
If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Select your manager software from the list below and click Download.
Cited By
- Oxidative Stress and Risk of Dementia in Older Patients with Depression: A Longitudinal Cohort Study Using Plasma Biomarkers, Medicina, 61, 1, (108), (2025).https://doi.org/10.3390/medicina61010108
- Early Spatio-Temporal and Cognitive Deficits in Alzheimer’s Disease, Journal of Clinical Medicine, 14, 2, (579), (2025).https://doi.org/10.3390/jcm14020579
- Genetic Predisposition to Hippocampal Atrophy and Risk of Amnestic Mild Cognitive Impairment and Alzheimer’s Dementia, Geriatrics, 10, 1, (14), (2025).https://doi.org/10.3390/geriatrics10010014
- Association of CSF soluble TREM1 levels with hippocampal atrophy in cognitively impaired older adults, Frontiers in Aging Neuroscience, 16, (2025).https://doi.org/10.3389/fnagi.2024.1481526
- Association Between Serum Follicle-Stimulating Hormone Levels and Cognitive Function in Middle-Aged and Older Women, Journal of Korean Medical Science, 40, (2025).https://doi.org/10.3346/jkms.2025.40.e15
- Updated Appropriate Use Criteria for Amyloid and Tau PET: A Report from the Alzheimer’s Association and Society for Nuclear Medicine and Molecular Imaging Workgroup, Journal of Nuclear Medicine, (jnumed.124.268756), (2025).https://doi.org/10.2967/jnumed.124.268756
- Cognitive Activity From Early to Late Life and the Risk of AD Dementia, Neurology Open Access, 1, 1, (2025).https://doi.org/10.1212/WN9.0000000000000002
- Exome sequencing reveals a rare damaging variant in GRIN2C in familial late-onset Alzheimer's disease, Alzheimer's Research & Therapy, 17, 1, (2025).https://doi.org/10.1186/s13195-024-01661-y
- An 11-Fold Higher Risk of Incident Mild Cognitive Impairment With Hispanic Ethnicity and Baseline Neuropsychiatric Symptoms, The Journal of Neuropsychiatry and Clinical Neurosciences, 37, 1, (29-37), (2025).https://doi.org/10.1176/appi.neuropsych.20230180
- Neuroinflammation-targeted magnetic resonance imaging nanoprobes for the early diagnosis of Alzheimer's disease, Journal of Materials Chemistry B, (2025).https://doi.org/10.1039/D4TB02210F
- See more
Loading...
View Options
Login options
Check if you have access through your login credentials or your institution to get full access on this article.
Personal login Institutional LoginPurchase Options
The neurology.org payment platform is currently offline. Our technical team is working as quickly as possible to restore service.
If you need immediate support or to place an order, please call or email customer service:
- 1-800-638-3030 for U.S. customers - 8:30 - 7 pm ET (M-F)
- 1-301-223-2300 for customers outside the U.S. - 8:30 - 7 pm ET (M-F)
- [email protected]
We appreciate your patience during this time and apologize for any inconvenience.