Plasma exchange and prednisone in Guillain‐Barré syndrome
A controlled randomized trial
Abstract
A controlled randomized trial of plasma exchange combined with prednisone was compared with supportive care alone in patients with Guillain-Barré syndrome (GBS). There was no significant improvement in the treated group over the controls. The sample size, albeit small (12 treated and 13 controls), had the power (95% chance) to detect a change of 2 British Medical Research Council grades of strength between the groups. The difference in our results and others that indicated a beneficial effect of plasma exchange may reflect an adverse effect of prednisone on recovery in GBS. Failure to find a benefit of plasma exchange in our patients also raises the possibility that GBS may be a heterogeneous disorder with humoral factors playing a role in some but not all patients.
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© 1985 by Modern Medicine Publications, Inc.
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Published online: November 1, 1985
Published in print: November 1985
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- The immunotherapy of Guillain-Barré syndrome, Expert Opinion on Biological Therapy, 18, 6, (619-631), (2018).https://doi.org/10.1080/14712598.2018.1468885
- Plasma exchange for Guillain-Barré syndrome, Cochrane Database of Systematic Reviews, 2017, 3, (2017).https://doi.org/10.1002/14651858.CD001798.pub3
- Topical Review: Childhood Guillain-Barré Syndrome: Clinical Presentation, Diagnosis, and Therapy, Journal of Child Neurology, 11, 1, (4-12), (2016).https://doi.org/10.1177/088307389601100102
- Intravenous immunoglobulin in very severe childhood Guillain-Barré syndrome, Annals of Tropical Paediatrics, 19, 2, (167-174), (2016).https://doi.org/10.1080/02724939992491
- Corticosteroids for Guillain-Barré syndrome, Cochrane Database of Systematic Reviews, 2016, 10, (2016).https://doi.org/10.1002/14651858.CD001446.pub5
- Intravenous immunoglobulin in treatment of autoimmune neurological diseases in children, Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova, 115, 8, (83), (2015).https://doi.org/10.17116/jnevro20151156183-93
- Peripheral nerve disorders, Evidence‐Based Neurology: Management of Neurological Disorders, (235-242), (2015).https://doi.org/10.1002/9781119067344.ch22
- Management of Guillain-Barré syndrome, Expert Review of Neurotherapeutics, 1, 1, (119-129), (2014).https://doi.org/10.1586/14737175.1.1.119
- Plasma exchange for Guillain-Barré syndrome, Cochrane Database of Systematic Reviews, (2012).https://doi.org/10.1002/14651858.CD001798.pub2
- Corticosteroids for Guillain-Barré syndrome, Cochrane Database of Systematic Reviews, (2012).https://doi.org/10.1002/14651858.CD001446.pub4
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