A case‐control study of smoking habits, dementia, and other illnesses in idiopathic Parkinson's disease
Abstract
From 1967 to 1979, 118 incident cases of idiopathic Parkinson's disease (IPD) and 236 age- and sex-matched controls from Rochester, MN, were identified. Medical records on patients and controls for 40 years preceding the diagnosis of IPD were reviewed. The relative risk (RR) for ever-smoked and IPD was not significantly different from unity (RR = 0.7, 95% confidence interval = 0.4 to 1.2). The mean age at diagnosis of IPD was significantly younger (p = 0.007) in the ever-smokers (68.8 years) compared with never-smokers (73.8 years), although this needs to be interpreted cautiously. It is concluded that smoking had no effect on the development of IPD. Within 5 years after the index date, a new diagnosis of dementia was made more often in cases than in controls (p = 0.01). Relative risk of IPD significantly increased when prior diagnosis of psychoneurosis and psychosomatic illness had been made.
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© 1987 by the American Academy of Neurology.
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Published online: February 1, 1987
Published in print: February 1987
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- Risk factors for dementia diagnosis in German primary care practices, International Psychogeriatrics, 28, 7, (1059-1065), (2016).https://doi.org/10.1017/S1041610215002082
- Early Nicotine Exposure Is Protective in Familial and Idiopathic Models of Parkinson’s Disease, Mitochondrial Mechanisms of Degeneration and Repair in Parkinson's Disease, (219-229), (2016).https://doi.org/10.1007/978-3-319-42139-1_11
- Frequency and Cause of Parkinson’s Disease, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 19, S1, (103-107), (2015).https://doi.org/10.1017/S0317167100041457
- Psychiatric diseases predated the occurrence of Parkinson disease: a retrospective cohort study, Annals of Epidemiology, 24, 3, (206-213), (2014).https://doi.org/10.1016/j.annepidem.2013.12.010
- Genetic comorbidities in Parkinson's disease, Human Molecular Genetics, 23, 3, (831-841), (2013).https://doi.org/10.1093/hmg/ddt465
- Dementias, Neurology in Clinical Practice, (1534-1582), (2012).https://doi.org/10.1016/B978-1-4377-0434-1.00091-8
- The relevance of clinical subtypes for disease course, family history and epidemiological variables in Parkinson's disease, European Journal of Neurology, 1, 1, (65-72), (2011).https://doi.org/10.1111/j.1468-1331.1994.tb00052.x
- Epidemiology and etiology of Parkinson’s disease: a review of the evidence, European Journal of Epidemiology, 26, S1, (1-58), (2011).https://doi.org/10.1007/s10654-011-9581-6
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