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March 1, 1987

Positron emission tomography and histopathology in Pick's disease

H. Kamo, MD, PhD, P. L. McGeer, MD, PhD, R. Harrop, PhD, E. G. McGeer, PhD, D. B. Calne, MB, BS, FRCP, W. R. W. Martin, MD, FRCPC, and B. D. Pate, PhDAuthors Info & Affiliations
March 1987 issue
37 (3) 439
https://doi.org/10.1212/WNL.37.3.439
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Abstract

PET using 18F-2-fluoro-2-deoxyglucose was carried out on a case of Pick's disease established by necropsy. A sharply decreased cortical metabolic rate for glucose was obtained in specific gyri, especially in the frontal lobes, where there was extensive gliosis and neuronal loss. More moderate decreases were found in areas with numerous Pick bodies and inflated neurons but less gliosis. The PET pattern was sufficiently distinctive to suggest that it might be possible to distinguish Pick's from Alzheimer's disease premortem.

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Information & Authors

Information

Published In

Neurology®
Volume 37 • Number 3 • March 1987
Pages: 439
PubMed: 3493451

Copyright

© 1987 by the American Academy of Neurology.

Publication History

Published online: March 1, 1987
Published in print: March 1987

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Affiliations & Disclosures

H. Kamo, MD, PhD
Kinsmen Laboratory of Neurological Research (Drs. Kamo, P.L. McGeer, and E.G. McGeer), the Departments of Medicine (Drs. Calne and Martin) and Psychiatry (Drs. Kamo, P.L. McGeer, and E.G. McGeer), Faculty of Pharmaceutical Sciences (Dr. Pate), The UBC/TRIUMF Program on Positron Emission Tomography (Drs. Harrop and Pate), University of British Columbia, Vancouver, and the School of Computing Science (Dr. Harrop), Simon Fraser University, Burnaby, British Columbia, Canada.
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P. L. McGeer, MD, PhD
Kinsmen Laboratory of Neurological Research (Drs. Kamo, P.L. McGeer, and E.G. McGeer), the Departments of Medicine (Drs. Calne and Martin) and Psychiatry (Drs. Kamo, P.L. McGeer, and E.G. McGeer), Faculty of Pharmaceutical Sciences (Dr. Pate), The UBC/TRIUMF Program on Positron Emission Tomography (Drs. Harrop and Pate), University of British Columbia, Vancouver, and the School of Computing Science (Dr. Harrop), Simon Fraser University, Burnaby, British Columbia, Canada.
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R. Harrop, PhD
Kinsmen Laboratory of Neurological Research (Drs. Kamo, P.L. McGeer, and E.G. McGeer), the Departments of Medicine (Drs. Calne and Martin) and Psychiatry (Drs. Kamo, P.L. McGeer, and E.G. McGeer), Faculty of Pharmaceutical Sciences (Dr. Pate), The UBC/TRIUMF Program on Positron Emission Tomography (Drs. Harrop and Pate), University of British Columbia, Vancouver, and the School of Computing Science (Dr. Harrop), Simon Fraser University, Burnaby, British Columbia, Canada.
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E. G. McGeer, PhD
Kinsmen Laboratory of Neurological Research (Drs. Kamo, P.L. McGeer, and E.G. McGeer), the Departments of Medicine (Drs. Calne and Martin) and Psychiatry (Drs. Kamo, P.L. McGeer, and E.G. McGeer), Faculty of Pharmaceutical Sciences (Dr. Pate), The UBC/TRIUMF Program on Positron Emission Tomography (Drs. Harrop and Pate), University of British Columbia, Vancouver, and the School of Computing Science (Dr. Harrop), Simon Fraser University, Burnaby, British Columbia, Canada.
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D. B. Calne, MB, BS, FRCP
Kinsmen Laboratory of Neurological Research (Drs. Kamo, P.L. McGeer, and E.G. McGeer), the Departments of Medicine (Drs. Calne and Martin) and Psychiatry (Drs. Kamo, P.L. McGeer, and E.G. McGeer), Faculty of Pharmaceutical Sciences (Dr. Pate), The UBC/TRIUMF Program on Positron Emission Tomography (Drs. Harrop and Pate), University of British Columbia, Vancouver, and the School of Computing Science (Dr. Harrop), Simon Fraser University, Burnaby, British Columbia, Canada.
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W. R. W. Martin, MD, FRCPC
Kinsmen Laboratory of Neurological Research (Drs. Kamo, P.L. McGeer, and E.G. McGeer), the Departments of Medicine (Drs. Calne and Martin) and Psychiatry (Drs. Kamo, P.L. McGeer, and E.G. McGeer), Faculty of Pharmaceutical Sciences (Dr. Pate), The UBC/TRIUMF Program on Positron Emission Tomography (Drs. Harrop and Pate), University of British Columbia, Vancouver, and the School of Computing Science (Dr. Harrop), Simon Fraser University, Burnaby, British Columbia, Canada.
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B. D. Pate, PhD
Kinsmen Laboratory of Neurological Research (Drs. Kamo, P.L. McGeer, and E.G. McGeer), the Departments of Medicine (Drs. Calne and Martin) and Psychiatry (Drs. Kamo, P.L. McGeer, and E.G. McGeer), Faculty of Pharmaceutical Sciences (Dr. Pate), The UBC/TRIUMF Program on Positron Emission Tomography (Drs. Harrop and Pate), University of British Columbia, Vancouver, and the School of Computing Science (Dr. Harrop), Simon Fraser University, Burnaby, British Columbia, Canada.
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