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February 1, 1990

Botulinum toxin injections for cervical dystonia

February 1990 issue
40 (2) 277

Abstract

We followed 205 of 232 patients with medically intractable cervical dystonia for at least 3 months and up to 4 years, during which time they received 1,074 injections in 505 visits. One hundred forty-five of the 205 patients (71%) improved substantially (global rating $2; from 0 = no response to 4 = marked improvement in severity and function) after 1 or more visits. Of the 89 patients who reported pain, 68 (76%) had almost complete relief of their pain. While most patients noted improvement within the 1st week after injection, some had a latency of up to 8.5 weeks. Duration of maximum benefit lasted up to 12.5 months in some, but the average was 11.2 weeks. Only 58 of 205 (28%) patients, seen in 76 of 505 visits (15% of all visits), had complications, primarily mild dysphagia (35 patients) or neck weakness (17 patients). We conclude that botulinum toxin is a safe and effective therapy for most patients with cervical dystonia.

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Published In

Neurology®
Volume 40Number 2February 1990
Pages: 277
PubMed: 2300249

Publication History

Published online: February 1, 1990
Published in print: February 1990

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Affiliations & Disclosures

J. Jankovic, MD, and
Department of Neurology, Baylor College of Medicine, Houston, TX.
K. Schwartz, PA
Department of Neurology, Baylor College of Medicine, Houston, TX.

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Cited By
  1. Treatment of cervical dystonia with Botox (onabotulinumtoxinA): Development, insights, and impact, Medicine, 102, S1, (e32403), (2023).https://doi.org/10.1097/MD.0000000000032403
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  2. Botulinum toxin A and neuropathic pain: An update, Toxicon, 232, (107208), (2023).https://doi.org/10.1016/j.toxicon.2023.107208
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  3. Botulinum Toxin Treatment of Spasmodic Torticollis, Journal of the Royal Society of Medicine, 85, 9, (524-529), (2022).https://doi.org/10.1177/014107689208500906
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  4. Spasmodic Torticollis, Journal of the Royal Society of Medicine, 85, 9, (517-518), (2022).https://doi.org/10.1177/014107689208500903
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  5. Treatment of Dystonic Pain with Botulinum Neurotoxins, Botulinum Toxin Treatment of Pain Disorders, (235-253), (2022).https://doi.org/10.1007/978-3-030-99650-5_12
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  6. Treatment of dystonia, Principles and Practice of Movement Disorders, (353-370.e10), (2021).https://doi.org/10.1016/B978-0-323-31071-0.00012-3
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  7. The Efficacy and Safety of Botulinum Toxin Injections in Preventing Postoperative Scars and Improving Scar Quality: A Systematic Review and Meta-Analysis, Aesthetic Plastic Surgery, 45, 5, (2350-2362), (2021).https://doi.org/10.1007/s00266-021-02196-5
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  8. Comparative Effectiveness of Botulinum Toxin Injection for Chronic Shoulder Pain: A Meta-Analysis of Randomized Controlled Trials, Toxins, 12, 4, (251), (2020).https://doi.org/10.3390/toxins12040251
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  9. Adverse Events Associated With Botox as Reported in a Food and Drug Administration Database, Aesthetic Plastic Surgery, 45, 3, (1201-1209), (2020).https://doi.org/10.1007/s00266-020-02027-z
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  10. Use of Botulinum Toxin A in Postmastectomy Breast Reconstruction, Botulinum Toxin Treatment in Surgery, Dentistry, and Veterinary Medicine, (187-193), (2020).https://doi.org/10.1007/978-3-030-50691-9_9
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