Skip to main content
AAN.com
articles
May 1, 1991

Severity and specificity of cognitive impairment in Alzheimer's, Huntington's, and Parkinson's diseases and progressive supranuclear palsy

May 1991 issue
41 (5) 634-643

Abstract

To investigate differences in severity and specificity of cognitive impairment among various neuro‐degenerative diseases, we tested groups of patients presenting with senile dementia of the Alzheimer type (SDAT; 44), progressive supranuclear palsy (PSP; 45), Huntington's disease (HD; 35) and Parkinson's disease (PD; 164), with an extensive neuropsychological battery. We found dementia, as defined by a global intellectual performance 2 standard deviations lower than mean control values, in 93% of SDAT, 66% of HD, 58% of PSP, and 18% of PD patients. Specific features of cognitive impairment distinguished the four groups of patients once they were matched for level of intellectual deterioration: remote memory and linguistic disorders in SDAT, frontal lobe‐like abnormalities in PSP, concentration and acquisition disorders in HD. There was no specific alteration in demented PD patients. This study demonstrates the frequency of dementia in predominantly subcortical degenerative diseases and indicates that “subcortical dementia,” rather than being a homogeneous entity, should be divided into specific subtypes of cognitive impairment related to different underlying specific lesions of each disease.
NEUROLOGY 1991;41:634‐643

Get full access to this article

View all available purchase options and get full access to this article.

Information & Authors

Information

Published In

Neurology®
Volume 41Number 5May 1991
Pages: 634-643
PubMed: 1827513

Publication History

Published online: May 1, 1991
Published in print: May 1991

Permissions

Request permissions for this article.

Authors

Affiliations & Disclosures

Notes

Address correspondence and reprint requests to Dr. Bernard Pillon, INSERM U 289 and Service de Neurologie et Neuropsychologie, Hôpital de la Salpêtrière, 47, Bd de l'Hôpital, 75651 Paris Cédex 13, France.

Metrics & Citations

Metrics

Citations

Download Citations

If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Select your manager software from the list below and click Download.

Cited By
  1. Cognitive performance in healthy clinical trial participants and patients with the NeuroCart, a neurodegenerative disease measured with an automated neuropsychological and neurophysiological test battery, Journal of the Neurological Sciences, 449, (120658), (2023).https://doi.org/10.1016/j.jns.2023.120658
    Crossref
  2. Validity, diagnostics and feasibility of the Italian version of the Montreal Cognitive Assessment (MoCA) in Huntington’s disease, Neurological Sciences, (2023).https://doi.org/10.1007/s10072-023-07070-7
    Crossref
  3. Pathomechanisms of cognitive impairment in progressive supranuclear palsy, Journal of Neural Transmission, 130, 4, (481-493), (2023).https://doi.org/10.1007/s00702-023-02613-w
    Crossref
  4. Huntington disease, Principles and Practice of Movement Disorders, (371-400.e14), (2021).https://doi.org/10.1016/B978-0-323-31071-0.00013-5
    Crossref
  5. Is Methylphenidate Beneficial and Safe in Pharmacological Cognitive Enhancement?, CNS Drugs, 34, 10, (1045-1062), (2020).https://doi.org/10.1007/s40263-020-00758-w
    Crossref
  6. Language impairment in progressive supranuclear palsy and corticobasal syndrome, Journal of Neurology, 268, 3, (796-809), (2019).https://doi.org/10.1007/s00415-019-09463-1
    Crossref
  7. Movement Disorders with Dementia in Older Adults, Handbook on the Neuropsychology of Aging and Dementia, (543-575), (2019).https://doi.org/10.1007/978-3-319-93497-6_34
    Crossref
  8. Neuropsychology of Movement Disorders and Motor Neuron Disease: Parkinson’s Disease, Progressive Supranuclear Palsy, Essential Tremor, Huntington’s Disease, and Amyotrophic Lateral Sclerosis, Handbook of Medical Neuropsychology, (415-440), (2019).https://doi.org/10.1007/978-3-030-14895-9_19
    Crossref
  9. Sensitivity and Specificity of the ECAS in Parkinson’s Disease and Progressive Supranuclear Palsy, Parkinson's Disease, 2018, (1-8), (2018).https://doi.org/10.1155/2018/2426012
    Crossref
  10. The Neuropsychology of Huntington's Disease, Archives of Clinical Neuropsychology, 32, 7, (876-887), (2017).https://doi.org/10.1093/arclin/acx086
    Crossref
  11. See more
Loading...

View Options

Get Access

Login options

Check if you have access through your login credentials or your institution to get full access on this article.

Personal login Institutional Login
Purchase Options

Purchase this article to access the full text.

Purchase Access, $39 for 24hr of access

View options

Full Text

View Full Text

Media

Figures

Other

Tables

Share

Share

Share article link

Share