Frontal lobe degeneration
Clinical, neuropsychological, and SPECT characteristics
Abstract
The clinical, neuropsychological, and cerebral blood flow characteristics of eight patients with frontal lobe degeneration (FLD) were studied. Social withdrawal and behavioral disinhibition were the earliest and most common clinical presentations, and psychiatric symptoms typically preceded the onset of dementia by several years. Neuropsychological testing showed selective impairment of frontal and memory tasks with relative sparing of attention, language, and visuospatial skills. Single-photon emission computerized tomography demonstrated frontal and temporal hypoperfusion with relative sparing of parietal and occipital blood flow. Previous studies suggest that the neuropathologic findings in patients with FLD are varied; some demonstrate frontal gliosis, neuronal loss, and Pick bodies while others show only gliosis and neuronal loss.
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© 1991 by Edgell Communications, Inc.
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Published online: September 1, 1991
Published in print: September 1991
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- Utility of clinical criteria in differentiating frontotemporal lobar degeneration (FTLD) from AD, Neurology, 58, 11, (1608-1615), (2023)./doi/10.1212/WNL.58.11.1608
- MicroRNA biomarkers in frontotemporal dementia and to distinguish from Alzheimer’s disease and amyotrophic lateral sclerosis, Neural Regeneration Research, 17, 7, (1412), (2022).https://doi.org/10.4103/1673-5374.330591
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- Frontotemporal lobar degeneration with TAR DNA-binding protein 43 (TDP-43): its journey of more than 100 years, Journal of Neurology, 269, 8, (4030-4054), (2022).https://doi.org/10.1007/s00415-022-11073-3
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