Frontal lobe degeneration
Clinical, neuropsychological, and SPECT characteristics
Abstract
The clinical, neuropsychological, and cerebral blood flow characteristics of eight patients with frontal lobe degeneration (FLD) were studied. Social withdrawal and behavioral disinhibition were the earliest and most common clinical presentations, and psychiatric symptoms typically preceded the onset of dementia by several years. Neuropsychological testing showed selective impairment of frontal and memory tasks with relative sparing of attention, language, and visuospatial skills. Single-photon emission computerized tomography demonstrated frontal and temporal hypoperfusion with relative sparing of parietal and occipital blood flow. Previous studies suggest that the neuropathologic findings in patients with FLD are varied; some demonstrate frontal gliosis, neuronal loss, and Pick bodies while others show only gliosis and neuronal loss.
Get full access to this article
View all available purchase options and get full access to this article.
Information & Authors
Information
Published In
Copyright
© 1991 by Edgell Communications, Inc.
Publication History
Published online: September 1, 1991
Published in print: September 1991
Authors
Metrics & Citations
Metrics
Citations
Download Citations
If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Select your manager software from the list below and click Download.
Cited By
- Long-term, home-based transcranial direct current stimulation coupled with computerized cognitive training in frontotemporal dementia: A case report, Journal of Central Nervous System Disease, 16, (2024).https://doi.org/10.1177/11795735241258435
- Frontotemporal dementia: from genetics to therapeutic approaches, Expert Opinion on Investigational Drugs, 33, 6, (561-573), (2024).https://doi.org/10.1080/13543784.2024.2349286
- Symptoms and Diagnosis of Dementia, Nutrition in Brain Aging and Dementia, (59-91), (2024).https://doi.org/10.1007/978-981-97-4117-5_3
- Utility of clinical criteria in differentiating frontotemporal lobar degeneration (FTLD) from AD, Neurology, 58, 11, (1608-1615), (2023)./doi/10.1212/WNL.58.11.1608
- MicroRNA biomarkers in frontotemporal dementia and to distinguish from Alzheimer’s disease and amyotrophic lateral sclerosis, Neural Regeneration Research, 17, 7, (1412), (2022).https://doi.org/10.4103/1673-5374.330591
- Changing perspectives on frontotemporal dementia: A review, Journal of Neuropsychology, 17, 2, (211-234), (2022).https://doi.org/10.1111/jnp.12297
- Frontotemporal dementia: A unique window on the functional role of the temporal lobes, The Temporal Lobe, (429-448), (2022).https://doi.org/10.1016/B978-0-12-823493-8.00011-0
- Frontotemporal lobar degeneration with TAR DNA-binding protein 43 (TDP-43): its journey of more than 100 years, Journal of Neurology, 269, 8, (4030-4054), (2022).https://doi.org/10.1007/s00415-022-11073-3
- Regional and hemispheric susceptibility of the temporal lobe to FTLD-TDP type C pathology, NeuroImage: Clinical, 28, (102369), (2020).https://doi.org/10.1016/j.nicl.2020.102369
- Perfusion SPECT: Its Role in the Diagnosis and Differential Diagnosis of Alzheimer’s Disease, with Particular Emphasis on Guidelines, PET and SPECT in Neurology, (453-468), (2020).https://doi.org/10.1007/978-3-030-53168-3_14
- See more
Loading...
View Options
Get Access
Login options
Check if you have access through your login credentials or your institution to get full access on this article.
Personal login Institutional LoginPurchase Options
The neurology.org payment platform is currently offline. Our technical team is working as quickly as possible to restore service.
If you need immediate support or to place an order, please call or email customer service:
- 1-800-638-3030 for U.S. customers - 8:30 - 7 pm ET (M-F)
- 1-301-223-2300 for customers outside the U.S. - 8:30 - 7 pm ET (M-F)
- [email protected]
We appreciate your patience during this time and apologize for any inconvenience.