Skip to main content
AAN.com
Articles
September 1, 1991

Frontal lobe degeneration
Clinical, neuropsychological, and SPECT characteristics

September 1991 issue
41 (9) 1374

Abstract

The clinical, neuropsychological, and cerebral blood flow characteristics of eight patients with frontal lobe degeneration (FLD) were studied. Social withdrawal and behavioral disinhibition were the earliest and most common clinical presentations, and psychiatric symptoms typically preceded the onset of dementia by several years. Neuropsychological testing showed selective impairment of frontal and memory tasks with relative sparing of attention, language, and visuospatial skills. Single-photon emission computerized tomography demonstrated frontal and temporal hypoperfusion with relative sparing of parietal and occipital blood flow. Previous studies suggest that the neuropathologic findings in patients with FLD are varied; some demonstrate frontal gliosis, neuronal loss, and Pick bodies while others show only gliosis and neuronal loss.

Get full access to this article

View all available purchase options and get full access to this article.

Information & Authors

Information

Published In

Neurology®
Volume 41Number 9September 1991
Pages: 1374
PubMed: 1891084

Publication History

Published online: September 1, 1991
Published in print: September 1991

Permissions

Request permissions for this article.

Authors

Affiliations & Disclosures

B. L. Miller, MD
Department of Neurology (Dr. Miller), Harbor-UCLA Medical Center; Departments of Neurology, and Psychiatry and Biobehavioral Services (Dr. Cummings), UCLA Medical Center; Departments of Nuclear Medicine (Drs. Villanueva-Meyer and Mena), Psychiatry (Drs. Boone and Lesser), and Radiology (Dr. Mehringer), Harbor-UCLA Medical Center, Torrance, CA.
J. L. Cummings, MD
Department of Neurology (Dr. Miller), Harbor-UCLA Medical Center; Departments of Neurology, and Psychiatry and Biobehavioral Services (Dr. Cummings), UCLA Medical Center; Departments of Nuclear Medicine (Drs. Villanueva-Meyer and Mena), Psychiatry (Drs. Boone and Lesser), and Radiology (Dr. Mehringer), Harbor-UCLA Medical Center, Torrance, CA.
J. Villanueva-Meyer, MD
Department of Neurology (Dr. Miller), Harbor-UCLA Medical Center; Departments of Neurology, and Psychiatry and Biobehavioral Services (Dr. Cummings), UCLA Medical Center; Departments of Nuclear Medicine (Drs. Villanueva-Meyer and Mena), Psychiatry (Drs. Boone and Lesser), and Radiology (Dr. Mehringer), Harbor-UCLA Medical Center, Torrance, CA.
K. Boone, PhD
Department of Neurology (Dr. Miller), Harbor-UCLA Medical Center; Departments of Neurology, and Psychiatry and Biobehavioral Services (Dr. Cummings), UCLA Medical Center; Departments of Nuclear Medicine (Drs. Villanueva-Meyer and Mena), Psychiatry (Drs. Boone and Lesser), and Radiology (Dr. Mehringer), Harbor-UCLA Medical Center, Torrance, CA.
C. M. Mehringer, MD
Department of Neurology (Dr. Miller), Harbor-UCLA Medical Center; Departments of Neurology, and Psychiatry and Biobehavioral Services (Dr. Cummings), UCLA Medical Center; Departments of Nuclear Medicine (Drs. Villanueva-Meyer and Mena), Psychiatry (Drs. Boone and Lesser), and Radiology (Dr. Mehringer), Harbor-UCLA Medical Center, Torrance, CA.
I. M. Lesser, MD
Department of Neurology (Dr. Miller), Harbor-UCLA Medical Center; Departments of Neurology, and Psychiatry and Biobehavioral Services (Dr. Cummings), UCLA Medical Center; Departments of Nuclear Medicine (Drs. Villanueva-Meyer and Mena), Psychiatry (Drs. Boone and Lesser), and Radiology (Dr. Mehringer), Harbor-UCLA Medical Center, Torrance, CA.
I. Mena, MD
Department of Neurology (Dr. Miller), Harbor-UCLA Medical Center; Departments of Neurology, and Psychiatry and Biobehavioral Services (Dr. Cummings), UCLA Medical Center; Departments of Nuclear Medicine (Drs. Villanueva-Meyer and Mena), Psychiatry (Drs. Boone and Lesser), and Radiology (Dr. Mehringer), Harbor-UCLA Medical Center, Torrance, CA.

Metrics & Citations

Metrics

Citations

Download Citations

If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Select your manager software from the list below and click Download.

Cited By
  1. Utility of clinical criteria in differentiating frontotemporal lobar degeneration (FTLD) from AD, Neurology, 58, 11, (1608-1615), (2023)./doi/10.1212/WNL.58.11.1608
    Abstract
  2. MicroRNA biomarkers in frontotemporal dementia and to distinguish from Alzheimer’s disease and amyotrophic lateral sclerosis, Neural Regeneration Research, 17, 7, (1412), (2022).https://doi.org/10.4103/1673-5374.330591
    Crossref
  3. Changing perspectives on frontotemporal dementia: A review, Journal of Neuropsychology, 17, 2, (211-234), (2022).https://doi.org/10.1111/jnp.12297
    Crossref
  4. Frontotemporal dementia: A unique window on the functional role of the temporal lobes, The Temporal Lobe, (429-448), (2022).https://doi.org/10.1016/B978-0-12-823493-8.00011-0
    Crossref
  5. Frontotemporal lobar degeneration with TAR DNA-binding protein 43 (TDP-43): its journey of more than 100 years, Journal of Neurology, 269, 8, (4030-4054), (2022).https://doi.org/10.1007/s00415-022-11073-3
    Crossref
  6. Regional and hemispheric susceptibility of the temporal lobe to FTLD-TDP type C pathology, NeuroImage: Clinical, 28, (102369), (2020).https://doi.org/10.1016/j.nicl.2020.102369
    Crossref
  7. Perfusion SPECT: Its Role in the Diagnosis and Differential Diagnosis of Alzheimer’s Disease, with Particular Emphasis on Guidelines, PET and SPECT in Neurology, (453-468), (2020).https://doi.org/10.1007/978-3-030-53168-3_14
    Crossref
  8. Grant Report on PREDICT-ADFTD: Multimodal Imaging Prediction of AD/FTD and Differential Diagnosis, Journal of Psychiatry and Brain Science, (2019).https://doi.org/10.20900/jpbs.20190017
    Crossref
  9. Assessment of Behavioral Variant Frontotemporal Dementia, Handbook on the Neuropsychology of Aging and Dementia, (523-542), (2019).https://doi.org/10.1007/978-3-319-93497-6_33
    Crossref
  10. Progress and Challenges in Frontotemporal Dementia Research: A 20-Year Review, Journal of Alzheimer's Disease, 62, 3, (1467-1480), (2018).https://doi.org/10.3233/JAD-171087
    Crossref
  11. See more
Loading...

View Options

Get Access

Login options

Check if you have access through your login credentials or your institution to get full access on this article.

Personal login Institutional Login
Purchase Options

Purchase this article to get full access to it.

Purchase Access, $39 for 24hr of access

View options

Full Text

View Full Text

Media

Figures

Other

Tables

Share

Share

Share article link

Share