Levodopa‐nonresponsive Lewy body parkinsonism
Clinicopathologic study of two cases
Abstract
We report two patients with a primarily akinetic form of parkinsonism who were nonresponsive to treatment with levodopa. At autopsy, both patients had many Lewy bodies in brainstem and diencephalic nuclei, with sparse Lewy bodies in association cortices and more numerous Lewy bodies in the limbic cortices, consistent with the transitional form of Lewy body disease. These cases emphasize that (1) Lewy body Parkinson's disease cannot be excluded on the basis of atypical presentation or levodopa nonresponsiveness, and (2) the clinicopathologic spectrum of Lewy body disease is varied.
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© 1992 by the American Academy of Neurology.
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Published online: July 1, 1992
Published in print: July 1992
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- Parkinsonism, Principles and Practice of Movement Disorders, (82-120.e21), (2021).https://doi.org/10.1016/B978-0-323-31071-0.00004-4
- Is Levodopa Response a Valid Indicator of Parkinson's Disease?, Movement Disorders, 36, 4, (948-954), (2020).https://doi.org/10.1002/mds.28406
- Parkinson’s Disease: Changes in Daily Life, Changes in the Brain, (65-86), (2016).https://doi.org/10.1007/978-0-387-98188-8_4
- Familial Parkinson’s Disease: A Clinical Genetic Analysis, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 22, 4, (272-279), (2015).https://doi.org/10.1017/S0317167100039469
- Single photon-emission computed tomography imaging in early Parkinson’s disease, Expert Review of Neurotherapeutics, 8, 12, (1853-1864), (2014).https://doi.org/10.1586/14737175.8.12.1853
- Single Photon Emission Computed Tomography Striatal Asymmetry Index May Predict Dopaminergic Responsiveness in Parkinson Disease, Clinical Neuropharmacology, 34, 2, (71-73), (2011).https://doi.org/10.1097/WNF.0b013e318211f945
- Parkinsonism, Principles and Practice of Movement Disorders, (66-92), (2011).https://doi.org/10.1016/B978-1-4377-2369-4.00004-4
- Levodopa response in early Parkinson's disease, Movement Disorders, 24, 16, (2328-2336), (2009).https://doi.org/10.1002/mds.22759
- Hereditary Lewy‐Body Parkinsonism and Evidence for a Genetic Etiology of Parkinson's Disease, Brain Pathology, 2, 4, (309-320), (2008).https://doi.org/10.1111/j.1750-3639.1992.tb00708.x
- Parkinsonism, Principles and Practice of Movement Disorders, (79-103), (2007).https://doi.org/10.1016/B978-0-443-07941-2.50007-3
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