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September 1, 1992

Fast magnetic resonance diffusion‐weighted imaging of acute human stroke

September 1992 issue
42 (9) 1717


Rapid MRI of the molecular diffusion of water demonstrated cerebral infarcts in 32 patients. We studied these patients at various times following the onset of ischemic symptoms and found that diffusion-weighted imaging revealed the infarcts sooner than conventional T2-weighted spin-echo imaging did; four hyperacute infarcts were shown only by diffusion-weighted imaging. Acute infarcts had lower apparent diffusion coefficients (ADCs) than noninfarcted regions did. This relative difference in ADC reached a nadir in the first 24 hours and rose progressively thereafter. Chronic infarcts showed a relative increase in diffusion and were readily distinguishable from acute infarcts. The technique takes less than 2 minutes to apply using a standard 1.5-tesla scanner in the clinical setting. Diffusion-weighted imaging has the potential to play a role in improving the early anatomic diagnosis of stroke and therefore in the development and implementation of early stroke interventions.

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Published In

Volume 42Number 9September 1992
Pages: 1717
PubMed: 1513459

Publication History

Published online: September 1, 1992
Published in print: September 1992


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Affiliations & Disclosures

Harvard-Longwood Neurology Training Program and Departments of Neurology, Harvard Medical School, Beth Israel Hospital, Boston, MA (Dr. Warach and M. Ronthal)
Departments of Radiology, Harvard Medical School, Beth Israel Hospital, Boston, MA (Drs. Warach, Chien, Li, and Edelman).

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