Propagation of interictal epileptic activity in temporal lobe epilepsy
Abstract
Article abstract-We recorded interictal spikes with closely spaced scalp electrodes and sphenoidal electrodes in four patients with temporal lobe epilepsy. We used multiple dipole modeling to study the number, three-dimensional intracerebral location, time activity, and functional relationship of the neuronal sources underlying the epileptic spike complexes. In all patients, we found two significant sources generating the interictal spikes which showed considerable overlap in both space and time. Source 1 was located in the mesiobasal temporal lobe and generated a restricted negativity at the ipsilateral sphenoidal electrode and a widespread positivity over the vertex. Source 2 could be attributed to the lateral temporal neocortex and was associated with a relatively restricted negativity at the ipsilateral temporal electrodes and a more widespread positivity over the contralateral hemisphere. The sources were well separated in space, with an average distance of 45 mm between them. The time activities of both sources showed similar biphasic patterns, with the mesial source leading the lateral source by approximately 40 msec, suggesting propagation of interictal epileptic activity from the mesiobasal to the lateral temporal lobe.
NEUROLOGY 1995;45: 118-122
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REFERENCES
1.
Spencer SS, Williamson PD, Spencer DD, Mattson RH. Human hippocampal seizure spread studied by depth and subdural recording: the hippocampal commissure. Epilepsia 1987;28:479-489.
2.
Wieser HG. Selective amygdalohippocampectomy: indications, investigative technique and results. In: Symon L, Brihaye J, Guidetti B, et al, eds. Advances and technical standards in neurosurgery, vol. 13. Vienna: Springer, 1986:39-133.
3.
Blume WT, Borghesi JL, Lemieux JF. Interictal indices of temporal seizure origin. Ann Neurol 1993;34:703-709.
4.
Chung MY, Walczak TL, Lewis DV, Dawson DV, Radtke R. Temporal lobectomy and independent bitemporal interictal activity: what degree of lateralization is sufficient? Epilepsia 1991;32:195-201.
5.
So N, Gloor P, Quesney LF, Jones-Gotman M, Olivier A, Andermann F. Depth electrode investigations in patients with bitemporal epileptiform abnormalities. Ann Neurol 1989;25:423-431.
6.
Marks DA, Kratz A, Booke J, Spencer DD, Spencer SS. Comparison and correlation of surface and sphenoidal electrodes with simultaneous intracranial recording: an interictal study. Electroencephalogr Clin Neurophysiol 1992;82:23-29.
7.
Buser P, Bancaud J, Talairach J. Depth recordings in man in temporal lobe epilepsy. In: Brazier MAB, ed. Epilepsy: its phenomena in man. New York: Academic Press, 1973:67-97.
8.
Buser P, Bancaud J. Unilateral connections between amygdala and hippocampus in man: a study of epileptic patients with depth electrodes. Electroencephalogr Clin Neurophysiol 1983;55:1-12.
9.
Sutherling WW, Crandall PH, Cahan LD, Barth DS. The magnetic field of epileptic spikes agrees with intracranial localizations in complex partial epilepsy. Neurology 1988;38:778-786.
10.
Sutherling WW, Barth DS. Neocortical propagation in temporal lobe spike foci on magnetoencephalography and electroencephalography. Ann Neurol 1989;25:373-381.
11.
Stefan H, Schneider S, Abraham-Fuchs K, et al. The neocortico to mesio-basal limbic propagation of focal epileptic activity during the spike-wave complex. Electroencephalogr Clin Neurophysiol 1991;79:1-10.
12.
Baumgartner C, Sutherling WW, Di S, Barth DS. Investigation of multiple simultaneously active brain sources in the electroencephalogram. J Neurosci Methods 1989;30:175-184.
13.
Baumgartner C, Barth DS, Levesque MF, Sutherling WW. Functional anatomy of human hand sensorimotor cortex from spatiotemporal analysis of electrocorticography. Electroencephalogr Clin Neurophysiol 1991;78:56-65.
14.
Baumgartner C, Sutherling WW, Di S, Barth DS. Spatiotemporal modeling of cerebral evoked magnetic fields to median nerve stimulation. Electroencephalogr Clin Neurophysiol 1991;79:27-35.
15.
Baumgartner C. Clinical electrophysiology of the somatosensory cortex. Vienna: Springer, 1993.
16.
Scherg M. Fundamentals of dipole source potential analysis. In: Grandori F, Hoke M, Romani GL, eds. Auditory evoked magnetic fields and electric potentials. Advances in audiology, vol 6. Basel: Karger, 1990:40-69.
17.
Sharbrough F, Chatrian G, Lesser RP, Luders H, Nuwer M, Picton TW. American Electroencephalographic Society guidelines for standard electrode position nomenclature. J Clin Neurophysiol 1991;8:200-202.
18.
Sperling MR, Engel JJ. Sphenoidal electrodes. J Clin Neurophysiol 1986;3:67-73.
19.
Burgess RC. Design and integration of computer systems. In: Luders H, ed. Epilepsy surgery. New York: Raven Press, 1991:291-296.
20.
Ebner A, Collura T, Baumgartner C, Luders H. Registrierung temporaler Spikes mit einer nicht-zephalen Referenzelektrode (abstract). Z EEG-EMG 1993;24:186.
21.
Nunez PL. Electric fields of the brain: the neurophysics of EEG. New York: Oxford University Press, 1981.
22.
Geddes LA, Baker LE. The specific resistance of biological materials--a compendium of data for the biomedical engineer and physiologist. Med Biol Eng 1967;5:271-293.
23.
Darcey T. Methods for localization of electrical sources in the human brain and applications to the visual system. Pasadena, CA: California Institute of Technology, 1979. Thesis.
24.
Stok CJ. The inverse problem in EEG and MEG with applications to visual evoked responses. Twente, The Netherlands: University Twente, 1986. Thesis.
25.
Dillon WR, Goldstein M. Multivariate analysis. New York: Wiley, 1984.
26.
Press WR, Flannery BP, Teukolsky SA, Vetterling WT. Numerical recipes. Cambridge, UK: Cambridge University Press, 1986.
27.
Perrin F, Pernier J, Bertrand O, Echallier JF. Spherical splines for scalp potential and current density mapping. Electroencephalogr Clin Neurophysiol 1989;66:75-81.
28.
Ebersole JS, Wade PB. Spike voltage topography identifies two types of frontotemporal epileptic foci. Neurology 1991;41:1425-1433.
29.
Ebersole JS. EEG dipole modeling in complex partial epilepsy. Brain Topogr 1991;4:113-123.
30.
Scherg M, Ebersole JS. Models of brain sources. Brain Topogr 1993;5:419-423.
31.
Wilson CL, Isokawa M, Babb TL, Crandall PH. Functional connections in the human temporal lobe. I. Analysis of limbic system pathways using neuronal responses evoked by electrical stimulation. Exp Brain Res 1990;82:279-292.
32.
Polkey CE, Binnie CD, Janota I. Acute hippocampal recording and pathology at temporal lobe resection and amygdalo-hippocampectomy for epilepsy. J Neurol Neurosurg Psychiatry 1989;52:1050-1057.
33.
Cooper R, Winter AL, Crow HJ, Walter WG. Comparison of subcortical, cortical and scalp activity using chronically indwelling electrodes in man. Electroencephalogr Clin Neurophysiol 1965;18:217-228.
34.
Swadlow HA, Rosene DL, Waxman SG. Characteristics of interhemispheric impulse conduction between prelunate gyris of the rhesus monkey. Exp Brain Res 1978;33:455-467.
35.
Waxman SG, Bennet MV. Relative conduction velocities of small myelinated and non-myelinated fibers in the central nervous system. Nature 1972;338:217-219.
36.
Ruch TC, Patton HD, Woodbury JW, Towe AL. Neurophysiology. 2nd ed. Philadelphia: WB Saunders, 1965.
37.
Gloor P. Neuronal generators and the problem of localization in electroencephalography: application of volume conductor theory to electroencephalography. J Clin Neurophysiol 1985;2:327-354.
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Copyright 1995 by Modern Medicine Publications, Inc., a subsidiary of Edgell Communications, Inc.
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Published online: January 1, 1995
Published in print: January 1995
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