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June 1, 1996

Cerebral amyloid angiopathy in the brains of patients with Alzheimer's disease
The CERAD experience, part XV

June 1996 issue
46 (6) 1592-1596

Abstract

We studied the frequency, severity, and clinical correlations of cerebral amyloid angiopathy (CAA) in 117 CERAD subjects with autopsy-confirmed AD. Eighty-three percent showed at least a mild degree of amyloid angiopathy. Thirty of 117 brains (25.6%) showed moderate to severe CAA affecting the cerebral vessels in one or more cortical regions. These brains also showed a significantly higher frequency of hemorrhages or ischemic lesions than those of subjects with little or no amyloid angiopathy (43.3% versus 23.0%; odds ratio = 2.6, 95% CI = 1.1 to 6.2). High CAA scores also correlated with the presence of cerebral arteriosclerosis and with older age at onset of dementia. Our findings suggest that factors contributing to non-AD-related vascular pathology (e.g., atherosclerosis) may play a role in amyloid deposition in cerebral vessels in AD.
NEUROLOGY 1996;46: 1592-1596

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Published In

Neurology®
Volume 46Number 6June 1996
Pages: 1592-1596
PubMed: 8649554

Publication History

Published online: June 1, 1996
Published in print: June 1996

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Authors

Affiliations & Disclosures

From the University of California-San Diego and VA Medical Center, Department of Neurosciences (Drs. Ellis, Olichney, and Thal), San Diego, CA; VA Medical Center and Emory University School of Medicine, Department of Pathology and Laboratory Medicine (Dr. Mirra), Atlanta, GA; Department of Neurology (Dr. Morris), Washington University School of Medicine, St. Louis, MO; Department of Biostatistics (Dr. Beekly), University of Washington, Seattle, WA; and Duke University Medical Center, Division of Neurology (Dr. Heyman), Durham, NC.
Supported in part by a Fellowship in Geriatric Neurology from the Department of Veteran's Affairs and by National Institute on Aging Grants AG06790 and AG05131.
Received September 7, 1995. Accepted in final form October 2, 1995.
Address correspondence and reprint requests to Dr. Ronald J. Ellis, Alzheimer's Disease Research Center (0948), University of California (San Diego), La Jolla, CA 92093.

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