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January 1, 1998

Progressive supranuclear gaze palsy is in linkage disequilibrium with theτ and not the α-synuclein gene

J. J. Higgins, MD, I. Litvan, MD, L. T. Pho, BS, W. Li, PhD, and L. E. Nee, MSWAuthors Info & Affiliations
January 1998 issue
50 (1) 270-273
https://doi.org/10.1212/WNL.50.1.270
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Abstract

We studied two candidate genes, tau (τ) and α-synuclein (SNCA), for evidence of linkage disequilibrium on a group of unrelated individuals with progressive supranuclear palsy (PSP) and a group of age-matched control subjects. The τ a1 allele and the τ a1a1 genotype were overrepresented in individuals with PSP and the τ polymorphism was in linkage disequilibrium with the PSP disease locus when a recessive inheritance model was employed. We also report a lack of evidence to support linkage disequilibrium between PSP and the SNCA candidate Parkinson's disease gene on chromosome 4q21-q23.

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Information & Authors

Information

Published In

Neurology®
Volume 50 • Number 1 • January 1998
Pages: 270-273

Copyright

© 1998.

Publication History

Published online: January 1, 1998
Published in print: January 1998

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Authors

Affiliations & Disclosures

J. J. Higgins, MD
From the Clinical Neurogenetics Unit, Medical Neurology Branch (Dr. Higgins, and L.T. Pho and L.E. Nee) and Neuroepidemiology Branch (Dr. Litvan), National Institute of Neurological Disorders and Stroke National Institutes of Health, Bethesda, MD; and the Laboratory of Statistical Genetics (Dr. Li), Rockefeller University, New York, NY.
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I. Litvan, MD
From the Clinical Neurogenetics Unit, Medical Neurology Branch (Dr. Higgins, and L.T. Pho and L.E. Nee) and Neuroepidemiology Branch (Dr. Litvan), National Institute of Neurological Disorders and Stroke National Institutes of Health, Bethesda, MD; and the Laboratory of Statistical Genetics (Dr. Li), Rockefeller University, New York, NY.
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L. T. Pho, BS
From the Clinical Neurogenetics Unit, Medical Neurology Branch (Dr. Higgins, and L.T. Pho and L.E. Nee) and Neuroepidemiology Branch (Dr. Litvan), National Institute of Neurological Disorders and Stroke National Institutes of Health, Bethesda, MD; and the Laboratory of Statistical Genetics (Dr. Li), Rockefeller University, New York, NY.
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W. Li, PhD
From the Clinical Neurogenetics Unit, Medical Neurology Branch (Dr. Higgins, and L.T. Pho and L.E. Nee) and Neuroepidemiology Branch (Dr. Litvan), National Institute of Neurological Disorders and Stroke National Institutes of Health, Bethesda, MD; and the Laboratory of Statistical Genetics (Dr. Li), Rockefeller University, New York, NY.
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L. E. Nee, MSW
From the Clinical Neurogenetics Unit, Medical Neurology Branch (Dr. Higgins, and L.T. Pho and L.E. Nee) and Neuroepidemiology Branch (Dr. Litvan), National Institute of Neurological Disorders and Stroke National Institutes of Health, Bethesda, MD; and the Laboratory of Statistical Genetics (Dr. Li), Rockefeller University, New York, NY.
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Notes

Address correspondence and reprint requests to Dr. Joseph J. Higgins, Director, Clinical Neurogenetics, Wadsworth Center, New York State Dept. of Health, P.O. Box 509, Albany, NY 12201-0509.

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