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June 1, 1998

Relation between MR abnormalities and patterns of cognitive impairment in multiple sclerosis

June 1998 issue
50 (6) 1601-1608

Abstract

Objective This study correlated the extent of abnormalities detected by different magnetic resonance imaging (MRI) techniques [proton density (PD)-weighted, T1-weighted, and magnetization transfer imaging (MTI)] with the overall cognitive, frontal lobe, and memory impairments in patients with MS.
Patients There were 30 clinically definite MS patients, with different disease courses. Exclusion criteria: psychoactivelsteroid treatments, mood disorders, acute relapse phase.
Main Outcome Measures Neuropsychological test results. Total (TLL) and frontal (FLL) lesion loads assessed from PD-weighted, T1-weighted (22 patients), and MTI (22 patients) MRI scans. Average lesion MT ratios (MTR) and analysis of the MTR histograms from brain tissue axial slabs on MTI scans.
Results Patients with frontal lobe deficits (n = 15) or memory impairment (n = 17) had a higher TLL on PD scans (p = 0.04 and p = 0.01, respectively). Patients with frontal lobe deficits had higher FLL on PD scans (p = 0.01) and TLL on MTI (p = 0.03) scans. No significant relationships between the extent of T1-weighted lesion loads and the presence of any neuropsychological impairment. Mean MTR of both MS lesions and whole brain tissue was lower in patients with frontal lobe impairment (p = 0.04). MRI lesion loads correlated significantly with some neuropsychological test scores.
Conclusions Lesion loads on PD-weighted MRI and MTI-derived measures are associated with cognitive decline in MS patients. Overall macroscopic and microscopic brain damage is more important than the corresponding regional brain disease in determining deficits of selective cognitive domains.

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Published In

Neurology®
Volume 50Number 6June 1998
Pages: 1601-1608
PubMed: 9633700

Publication History

Published online: June 1, 1998
Published in print: June 1998

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Authors

Affiliations & Disclosures

M. Rovaris, MD
From the Department of Neurology, MS Biosignal Analysis Center, Scientific Institute Ospedale San Raffaele, University of Milan, Italy.
M. Filippi, MD
From the Department of Neurology, MS Biosignal Analysis Center, Scientific Institute Ospedale San Raffaele, University of Milan, Italy.
M. Falautano, PhD
From the Department of Neurology, MS Biosignal Analysis Center, Scientific Institute Ospedale San Raffaele, University of Milan, Italy.
L. Minicucci, PhD
From the Department of Neurology, MS Biosignal Analysis Center, Scientific Institute Ospedale San Raffaele, University of Milan, Italy.
M. A. Rocca, MD
From the Department of Neurology, MS Biosignal Analysis Center, Scientific Institute Ospedale San Raffaele, University of Milan, Italy.
V. Martinelli, MD
From the Department of Neurology, MS Biosignal Analysis Center, Scientific Institute Ospedale San Raffaele, University of Milan, Italy.
G. Comi, MD
From the Department of Neurology, MS Biosignal Analysis Center, Scientific Institute Ospedale San Raffaele, University of Milan, Italy.

Notes

Address correspondence and reprint requests to Dr. Massimo Filippi, Department of Neurology, MS Biosignal Analysis Center, Scientific Institute Ospedale San Raffaele, University of Milan, via Olgettina 60, 20132 Milan, Italy

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  1. T1 and T2 weighted lesions and cognition in multiple Sclerosis: A systematic review and meta-analysis, Journal of Clinical Neuroscience, 119, (1-7), (2024).https://doi.org/10.1016/j.jocn.2023.11.014
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  2. Multiple sclerosis lesions that impair memory map to a connected memory circuit, Journal of Neurology, 270, 11, (5211-5222), (2023).https://doi.org/10.1007/s00415-023-11907-8
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  3. Quantitative magnetization transfer imaging in relapsing-remitting multiple sclerosis: a systematic review and meta-analysis, Brain Communications, 4, 2, (2022).https://doi.org/10.1093/braincomms/fcac088
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  5. Literatur, Multiple Sklerose, (468-512), (2022).https://doi.org/10.1016/B978-3-437-22085-2.00028-8
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  8. Magnetresonanztomografie, Multiple Sklerose, (135-172), (2018).https://doi.org/10.1016/B978-3-437-22084-5.00012-3
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  9. The clinico-radiological paradox of cognitive function and MRI burden of white matter lesions in people with multiple sclerosis: A systematic review and meta-analysis, PLOS ONE, 12, 5, (e0177727), (2017).https://doi.org/10.1371/journal.pone.0177727
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  10. Lesion symptom map of cognitive–postural interference in multiple sclerosis, Multiple Sclerosis Journal, 24, 5, (653-662), (2017).https://doi.org/10.1177/1352458517701313
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