Multiple sclerosis flares associated with recombinant granulocyte colony-stimulating factor
Abstract
Article abstract Four of 10 patients who were enrolled on protocols of high-dose immunosuppression with peripheral blood stem cell rescue for MS experienced neurologic worsening while receiving recombinant human granulocyte colony-stimulating factor. There was improvement when methylprednisolone was given to three of the patients, but one patient died of respiratory failure. The mechanism of the neurologic worsening is uncertain.
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Publication History
Received: January 20, 2000
Accepted: February 10, 2000
Published online: June 13, 2000
Published in print: June 13, 2000
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