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April 25, 2000

Detection of ventricular enlargement in patients at the earliest clinical stage of MS

P.A. Brex, MRCP, R. Jenkins, BSc, N.C. Fox, MRCP, W.R. Crum, DPhil, J.I. O’Riordan, MRCP, G.T. Plant, FRCP, and D.H. Miller, FRCPAuthors Info & Affiliations
April 25, 2000 issue
54 (8) 1689-1691
https://doi.org/10.1212/WNL.54.8.1689
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Abstract

Article abstract The aim of this study was to determine whether atrophy could be detected at the earliest clinical stages of MS. Patients were selected from a 1-year follow-up MRI study of clinically isolated syndromes. Nine patients who developed MS were compared with eight matched patients who had no further symptoms. Significant ventricular enlargement occurred in the group that developed MS but not in the other group. Our findings show that atrophy, albeit mild, can be detected early in the course of MS.

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Information & Authors

Information

Published In

Neurology®
Volume 54 • Number 8 • April 25, 2000
Pages: 1689-1691

Copyright

© 2000.

Publication History

Received: October 26, 1999
Accepted: January 12, 2000
Published online: April 25, 2000
Published in print: April 25, 2000

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Authors

Affiliations & Disclosures

P.A. Brex, MRCP
From the NMR Research Unit (Drs. BrexO’Riordan, and Miller) and the Dementia Research Group (Drs. Fox and Crum, and R. Jenkins), Institute of Neurology, University College London; and Moorfields Eye Hospital (Dr. Plant), London, UK.
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R. Jenkins, BSc
From the NMR Research Unit (Drs. BrexO’Riordan, and Miller) and the Dementia Research Group (Drs. Fox and Crum, and R. Jenkins), Institute of Neurology, University College London; and Moorfields Eye Hospital (Dr. Plant), London, UK.
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N.C. Fox, MRCP
From the NMR Research Unit (Drs. BrexO’Riordan, and Miller) and the Dementia Research Group (Drs. Fox and Crum, and R. Jenkins), Institute of Neurology, University College London; and Moorfields Eye Hospital (Dr. Plant), London, UK.
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W.R. Crum, DPhil
From the NMR Research Unit (Drs. BrexO’Riordan, and Miller) and the Dementia Research Group (Drs. Fox and Crum, and R. Jenkins), Institute of Neurology, University College London; and Moorfields Eye Hospital (Dr. Plant), London, UK.
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J.I. O’Riordan, MRCP
From the NMR Research Unit (Drs. BrexO’Riordan, and Miller) and the Dementia Research Group (Drs. Fox and Crum, and R. Jenkins), Institute of Neurology, University College London; and Moorfields Eye Hospital (Dr. Plant), London, UK.
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G.T. Plant, FRCP
From the NMR Research Unit (Drs. BrexO’Riordan, and Miller) and the Dementia Research Group (Drs. Fox and Crum, and R. Jenkins), Institute of Neurology, University College London; and Moorfields Eye Hospital (Dr. Plant), London, UK.
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D.H. Miller, FRCP
From the NMR Research Unit (Drs. BrexO’Riordan, and Miller) and the Dementia Research Group (Drs. Fox and Crum, and R. Jenkins), Institute of Neurology, University College London; and Moorfields Eye Hospital (Dr. Plant), London, UK.
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Notes

Address correspondence and reprint requests to Professor D.H. Miller, NMR Research Group, 6th floor, Institute of Neurology, Queen Square, London WC1N 3BG, UK; e-mail: [email protected]

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