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September 26, 2000

Weekly diffusion-weighted imaging of normal-appearing white matter in MS

September 26, 2000 issue
55 (6) 882-884

Abstract

Article abstract To elucidate the dynamics and the nature of normal-appearing white matter (NAWM) changes preceding new lesion formation in MS, the authors obtained weekly diffusion-weighted images for 12 weeks from 6 patients. NAWM areas subsequently involved by enhancement had a significant increase in mean diffusivity values starting 6 weeks before the appearance of enhancement (p values ranging between < 0.0001 and 0.04). This suggests that focal edema and demyelination play a part in the NAWM changes preceding new lesion formation in MS.

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Information & Authors

Information

Published In

Neurology®
Volume 55Number 6September 26, 2000
Pages: 882-884
PubMed: 10994017

Publication History

Received: February 18, 2000
Accepted: May 24, 2000
Published online: September 26, 2000
Published in print: September 26, 2000

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Authors

Affiliations & Disclosures

M.A. Rocca, MD
From the Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute Ospedale San Raffaele, University of Milan, Italy.
M. Cercignani, MPhil
From the Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute Ospedale San Raffaele, University of Milan, Italy.
G. Iannucci, MD
From the Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute Ospedale San Raffaele, University of Milan, Italy.
G. Comi, MD
From the Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute Ospedale San Raffaele, University of Milan, Italy.
M. Filippi, MD
From the Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute Ospedale San Raffaele, University of Milan, Italy.

Notes

Address correspondence and reprint requests to Dr. Massimo Filippi, Neuroimaging Research Unit Department of Neuroscience, Scientific Institute Ospedale San Raffaele, Via Olgettina, 60, 20132 Milan, Italy.

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