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July 10, 2001

A prospective study of quality of life in ALS patients treated with noninvasive ventilation

July 10, 2001 issue
57 (1) 153-156

Abstract

Noninvasive positive pressure ventilation prolongs survival in ALS but its effect on quality of life is unknown. The authors prospectively studied quality of life using the SF-36 questionnaire in a cohort of 16 ventilated patients with ALS. Noninvasive positive pressure ventilation improved scores in the “Vitality” domain by as much as 25%, for periods of up to 15 months, despite disease progression. Noninvasive positive pressure ventilation did not cause reduced quality of life, as any fall in scores in the ventilated group were comparable to those seen in a control group. In conclusion, noninvasive positive pressure ventilation enhances quality of life when used to treat sleep-disordered breathing in patients with ALS.

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Information & Authors

Information

Published In

Neurology®
Volume 57Number 1July 10, 2001
Pages: 153-156
PubMed: 11445650

Publication History

Received: July 21, 2000
Accepted: March 4, 2001
Published online: July 10, 2001
Published in print: July 10, 2001

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Authors

Affiliations & Disclosures

R. A. Lyall, MBBS
From the Respiratory Muscle Laboratory (Drs. Lyall, Polkey, and Prof. Moxham, T. Fleming and C. Wood), Department of Respiratory Medicine, Guy’s, King’s, and St. Thomas’ School of Medicine; Department of Neurology and the Kings’ MND Care and Research Centre (Prof. Leigh), Institute of Psychiatry; the Department of Psychology (Dr. Newsom–Davis), Institute of Psychiatry; and the Department of Palliative Care and Policy (Dr. Donaldson), Guy’s, King’s and St. Thomas’ School of Medicine, Kings College Hospital, London, United Kingdom.
N. Donaldson, PhD
From the Respiratory Muscle Laboratory (Drs. Lyall, Polkey, and Prof. Moxham, T. Fleming and C. Wood), Department of Respiratory Medicine, Guy’s, King’s, and St. Thomas’ School of Medicine; Department of Neurology and the Kings’ MND Care and Research Centre (Prof. Leigh), Institute of Psychiatry; the Department of Psychology (Dr. Newsom–Davis), Institute of Psychiatry; and the Department of Palliative Care and Policy (Dr. Donaldson), Guy’s, King’s and St. Thomas’ School of Medicine, Kings College Hospital, London, United Kingdom.
T. Fleming, BSc
From the Respiratory Muscle Laboratory (Drs. Lyall, Polkey, and Prof. Moxham, T. Fleming and C. Wood), Department of Respiratory Medicine, Guy’s, King’s, and St. Thomas’ School of Medicine; Department of Neurology and the Kings’ MND Care and Research Centre (Prof. Leigh), Institute of Psychiatry; the Department of Psychology (Dr. Newsom–Davis), Institute of Psychiatry; and the Department of Palliative Care and Policy (Dr. Donaldson), Guy’s, King’s and St. Thomas’ School of Medicine, Kings College Hospital, London, United Kingdom.
C. Wood, HND
From the Respiratory Muscle Laboratory (Drs. Lyall, Polkey, and Prof. Moxham, T. Fleming and C. Wood), Department of Respiratory Medicine, Guy’s, King’s, and St. Thomas’ School of Medicine; Department of Neurology and the Kings’ MND Care and Research Centre (Prof. Leigh), Institute of Psychiatry; the Department of Psychology (Dr. Newsom–Davis), Institute of Psychiatry; and the Department of Palliative Care and Policy (Dr. Donaldson), Guy’s, King’s and St. Thomas’ School of Medicine, Kings College Hospital, London, United Kingdom.
I. Newsom–Davis, DClinPsy
From the Respiratory Muscle Laboratory (Drs. Lyall, Polkey, and Prof. Moxham, T. Fleming and C. Wood), Department of Respiratory Medicine, Guy’s, King’s, and St. Thomas’ School of Medicine; Department of Neurology and the Kings’ MND Care and Research Centre (Prof. Leigh), Institute of Psychiatry; the Department of Psychology (Dr. Newsom–Davis), Institute of Psychiatry; and the Department of Palliative Care and Policy (Dr. Donaldson), Guy’s, King’s and St. Thomas’ School of Medicine, Kings College Hospital, London, United Kingdom.
M. I. Polkey, PhD
From the Respiratory Muscle Laboratory (Drs. Lyall, Polkey, and Prof. Moxham, T. Fleming and C. Wood), Department of Respiratory Medicine, Guy’s, King’s, and St. Thomas’ School of Medicine; Department of Neurology and the Kings’ MND Care and Research Centre (Prof. Leigh), Institute of Psychiatry; the Department of Psychology (Dr. Newsom–Davis), Institute of Psychiatry; and the Department of Palliative Care and Policy (Dr. Donaldson), Guy’s, King’s and St. Thomas’ School of Medicine, Kings College Hospital, London, United Kingdom.
P. N. Leigh, PhD
From the Respiratory Muscle Laboratory (Drs. Lyall, Polkey, and Prof. Moxham, T. Fleming and C. Wood), Department of Respiratory Medicine, Guy’s, King’s, and St. Thomas’ School of Medicine; Department of Neurology and the Kings’ MND Care and Research Centre (Prof. Leigh), Institute of Psychiatry; the Department of Psychology (Dr. Newsom–Davis), Institute of Psychiatry; and the Department of Palliative Care and Policy (Dr. Donaldson), Guy’s, King’s and St. Thomas’ School of Medicine, Kings College Hospital, London, United Kingdom.
J. Moxham, MD
From the Respiratory Muscle Laboratory (Drs. Lyall, Polkey, and Prof. Moxham, T. Fleming and C. Wood), Department of Respiratory Medicine, Guy’s, King’s, and St. Thomas’ School of Medicine; Department of Neurology and the Kings’ MND Care and Research Centre (Prof. Leigh), Institute of Psychiatry; the Department of Psychology (Dr. Newsom–Davis), Institute of Psychiatry; and the Department of Palliative Care and Policy (Dr. Donaldson), Guy’s, King’s and St. Thomas’ School of Medicine, Kings College Hospital, London, United Kingdom.

Notes

Address correspondence and reprint requests to Dr. Rebecca Lyall, Respiratory Muscle Laboratory, Department of Respiratory Medicine, Guy’s, King’s and St. Thomas’ School of Medicine, Bessemer Road, London SE5 9PJ, UK; e-mail: rebecca.lyall@ kcl.ac.uk

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  1. Factors associated with adherence to noninvasive positive pressure ventilation in amyotrophic lateral sclerosis, PLOS ONE, 19, 5, (e0302515), (2024).https://doi.org/10.1371/journal.pone.0302515
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  2. Quality of Life and Stress Levels in Patients under Home Mechanical Ventilation: What Can We Do to Improve Functioning Patients at Home? A Survey Study, International Journal of Environmental Research and Public Health, 20, 1, (874), (2023).https://doi.org/10.3390/ijerph20010874
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  3. Sleep Disorders in Neuromuscular Diseases: A Narrative Review, Clinical and Translational Neuroscience, 7, 3, (23), (2023).https://doi.org/10.3390/ctn7030023
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  5. Palliative care in neurology patients, International Anesthesiology Clinics, 61, 3, (73-79), (2023).https://doi.org/10.1097/AIA.0000000000000403
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  8. Alveolar Ventilation-Targeted Versus Spontaneous/Timed Mode for Home Noninvasive Ventilation in Amyotrophic Lateral Sclerosis, Respiratory Care, 67, 9, (1109-1120), (2022).https://doi.org/10.4187/respcare.09580
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  9. Comparative Performance of Different Respiratory Test Parameters for Detection of Early Respiratory Insufficiency in Patients With ALS, Neurology, 99, 7, (e743-e750), (2022)./doi/10.1212/WNL.0000000000200758
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  10. The neuropalliative multidisciplinary team—Members and their roles, Neuropalliative Care, Part I, (33-59), (2022).https://doi.org/10.1016/B978-0-323-85029-2.00010-5
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