Skip to main content
AAN.com
Brief Communications
December 11, 2001

Cerebellar lesions impair rapid saccade amplitude adaptation

December 1, 2001 issue
57 (11) 2105-2108

Abstract

This study investigated whether the cerebellum is essential for rapid saccade adaptation. Saccade adaptation was elicited by 30% backward target steps during the primary saccade. Patients with cerebellar lesions adapted less than normal subjects, but saccade adaptation was most impaired in the group of patients with cerebellar degeneration. As the variability of the saccade gain in patients with cerebellar degeneration did not significantly differ from that in the other patients, the increased variability in motor performance due to a cerebellar lesion cannot alone explain this impaired adaptation.

Get full access to this article

View all available purchase options and get full access to this article.

Supplementary Material

File (straube.doc)

References

1.
Deubel H, Wolf W, Hauske G. Adaptive gain control of saccadic eye movements. Hum Neurobiol . 1986; 5: 245–253.
2.
Straube A, Fuchs AF, Usher S, Robinson FR. Characteristics of saccadic gain adaptation in rhesus monkeys. J Neurophysiol . 1997; 77: 874–895.
3.
Fuchs AF, Robinson FR, Straube A. Role of the caudal fastigial nucleus in saccade generation. I. Neuronal discharge patterns. J Neurophysiol . 1993; 70: 1723–1740.
4.
Optican LM, Robinson DA. Cerebellar-dependent adaptive control of primate saccadic system. J Neurophysiol . 1980; 44: 1058–1076.
5.
Goldberg ME, Musil SY, Fitzgibbon EJ, Smith M, Olson CR. The role of the cerebellum in the control of saccadic eye movements. In: Mano N, Hamada I, DeLong MR, eds. Role of cerebellum and basal ganglia in voluntary movement. Amsterdam: Elsevier Science, 1993: 203–211.
6.
Takagi M, Zee DS, Tamargo RJ. Effects of lesions of the oculomotor vermis on eye movements in primate: saccades. J Neurophysiol . 1998; 80: 1911–1931.
7.
Barash S, Melikyan A, Sivakov A, Zhang M, Glickstein M, Thier P. Saccade dysmetria and adaptation after lesions of the cerebellar cortex. J Neurosci . 1999; 19: 10931–10939.
8.
Waespe W, Baumgartner R. Enduring dysmetria and impaired adaptivity of saccadic eye movements in Wallenberg’s lateral medullary syndrome. Brain . 1992; 115: 1123–1146.
9.
Scollan DF, Nakamoto BK, Shelhamer M. Adaptability and variability of saccadic eye movements. Soc Neurosci Abstr . 1996; 22: 2033.
10.
Timmann D, Shimansky Y, Larson PE, Wunderlich DA, Stelmach GE, Bloedel JR. Visuomotor learning in cerebellar patients. Behav Brain Res 1996;81:99–113.

Information & Authors

Information

Published In

Neurology®
Volume 57Number 11December 1, 2001
Pages: 2105-2108
PubMed: 11739834

Publication History

Received: November 27, 2000
Accepted: June 28, 2001
Published in print: December 1, 2001
Published online: December 11, 2001

Permissions

Request permissions for this article.

Authors

Affiliations & Disclosures

Andreas Straube, MD
From the Department of Neurology (Drs. Straube, Ditterich, and Eggert), Klinikum Grosshadern, and Department of Psychology (Dr. Deubel), Ludwig Maximilians University, Munich, Germany.
Heiner Deubel, PhD
From the Department of Neurology (Drs. Straube, Ditterich, and Eggert), Klinikum Grosshadern, and Department of Psychology (Dr. Deubel), Ludwig Maximilians University, Munich, Germany.
Jochen Ditterich, PhD
From the Department of Neurology (Drs. Straube, Ditterich, and Eggert), Klinikum Grosshadern, and Department of Psychology (Dr. Deubel), Ludwig Maximilians University, Munich, Germany.
Thomas Eggert, PhD
From the Department of Neurology (Drs. Straube, Ditterich, and Eggert), Klinikum Grosshadern, and Department of Psychology (Dr. Deubel), Ludwig Maximilians University, Munich, Germany.

Notes

Address correspondence and reprint requests to Dr. A. Straube, Department of Neurology, Klinikum Grosshadern, Marchioninistrasse 15, 81377 Munich, Germany; e-mail: [email protected]

Metrics & Citations

Metrics

Citation information is sourced from Crossref Cited-by service.

Citations

Download Citations

If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Select your manager software from the list below and click Download.

Cited By
  1. No evidence for differential saccadic adaptation in children and adults with an autism spectrum diagnosis, Frontiers in Integrative Neuroscience, 17, (2023).https://doi.org/10.3389/fnint.2023.1232474
    Crossref
  2. Visual Circuits, Essentials of Cerebellum and Cerebellar Disorders, (69-76), (2023).https://doi.org/10.1007/978-3-031-15070-8_10
    Crossref
  3. Error inconsistency does not generally inhibit saccadic adaptation: Support for linear models of multi‐gainfield adaptation, Physiological Reports, 10, 4, (2022).https://doi.org/10.14814/phy2.15180
    Crossref
  4. Developmental maturation of causal signaling hubs in voluntary control of saccades and their functional controllability, Cerebral Cortex, 32, 21, (4746-4762), (2022).https://doi.org/10.1093/cercor/bhab514
    Crossref
  5. Cerebellar signals drive motor adjustments and visual perceptual changes during forward and backward adaptation of reactive saccades, Cerebral Cortex, 32, 18, (3896-3916), (2022).https://doi.org/10.1093/cercor/bhab455
    Crossref
  6. Neural substrates of saccadic adaptation: Plastic changes versus error processing and forward versus backward learning, NeuroImage, 262, (119556), (2022).https://doi.org/10.1016/j.neuroimage.2022.119556
    Crossref
  7. A differential role for the posterior cerebellum in the adaptive control of convergence eye movements, Brain Stimulation, 13, 1, (215-228), (2020).https://doi.org/10.1016/j.brs.2019.07.025
    Crossref
  8. Slow Saccades, Advances in Translational Neuroscience of Eye Movement Disorders, (203-219), (2020).https://doi.org/10.1007/978-3-030-31407-1_11
    Crossref
  9. Unconscious Semantic Priming Influences Performance of Visuomotor Tasks Differently but the Effects are Similar in Young and Older Adults, Journal of Motor Behavior, 51, 5, (580-586), (2019).https://doi.org/10.1080/00222895.2018.1545216
    Crossref
  10. Twenty years on: Myoclonus‐dystonia and ε‐sarcoglycan — neurodevelopment, channel, and signaling dysfunction, Movement Disorders, 34, 11, (1588-1601), (2019).https://doi.org/10.1002/mds.27822
    Crossref
  11. See more
Loading...

View Options

Login options

Check if you have access through your login credentials or your institution to get full access on this article.

Personal login Institutional Login
Purchase Options

The neurology.org payment platform is currently offline. Our technical team is working as quickly as possible to restore service.

If you need immediate support or to place an order, please call or email customer service:

  • 1-800-638-3030 for U.S. customers - 8:30 - 7 pm ET (M-F)
  • 1-301-223-2300 for customers outside the U.S. - 8:30 - 7 pm ET (M-F)
  • [email protected]

We appreciate your patience during this time and apologize for any inconvenience.

View options

PDF and All Supplements

Download PDF and Supplementary Material

Full Text

View Full Text

Full Text HTML

View Full Text HTML

Figures

Tables

Media

Share

Share

Share article link

Share