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September 25, 2001

Quantification of tissue damage in AD using diffusion tensor and magnetization transfer MRI

September 25, 2001 issue
57 (6) 1135-1137

Abstract

The authors measured mean diffusivity () and magnetization transfer ratio (MTR) of the brain from 18 patients with AD and 16 healthy control subjects. The peak heights of cortical gray matter (cGM) (p < 0.001) and MTR (p < 0.001) histograms were lower and average cGM (p < 0.01) higher in patients with AD than in control subjects. A composite MR score based on brain volume and cGM MTR peak height was correlated with patient cognitive impairment (r = 0.65, p = 0.003). This preliminary study presents a novel approach to quantify AD-related tissue damage in-vivo.

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Information & Authors

Information

Published In

Neurology®
Volume 57Number 6September 25, 2001
Pages: 1135-1137
PubMed: 11571355

Publication History

Received: February 22, 2001
Accepted: May 24, 2001
Published online: September 25, 2001
Published in print: September 25, 2001

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Authors

Affiliations & Disclosures

M. Bozzali, MD
From the Neuroimaging Research Unit (Drs. Bozzali, Cercignani, and Filippi) and the Clinical Trials Unit (Drs. Magnani and Comi), Department of Neuroscience, and the Department of Neuroradiology (Drs. Falini, Pontesilli, and Scotti), Scientific Institute and University H San Raffaele, Milan, Italy; and the Department of Neurology (Dr. Franceschi), H Santa Maria, Castellanza, Italy.
M. Franceschi, MD
From the Neuroimaging Research Unit (Drs. Bozzali, Cercignani, and Filippi) and the Clinical Trials Unit (Drs. Magnani and Comi), Department of Neuroscience, and the Department of Neuroradiology (Drs. Falini, Pontesilli, and Scotti), Scientific Institute and University H San Raffaele, Milan, Italy; and the Department of Neurology (Dr. Franceschi), H Santa Maria, Castellanza, Italy.
A. Falini, MD
From the Neuroimaging Research Unit (Drs. Bozzali, Cercignani, and Filippi) and the Clinical Trials Unit (Drs. Magnani and Comi), Department of Neuroscience, and the Department of Neuroradiology (Drs. Falini, Pontesilli, and Scotti), Scientific Institute and University H San Raffaele, Milan, Italy; and the Department of Neurology (Dr. Franceschi), H Santa Maria, Castellanza, Italy.
S. Pontesilli, MD
From the Neuroimaging Research Unit (Drs. Bozzali, Cercignani, and Filippi) and the Clinical Trials Unit (Drs. Magnani and Comi), Department of Neuroscience, and the Department of Neuroradiology (Drs. Falini, Pontesilli, and Scotti), Scientific Institute and University H San Raffaele, Milan, Italy; and the Department of Neurology (Dr. Franceschi), H Santa Maria, Castellanza, Italy.
M. Cercignani, MPhil
From the Neuroimaging Research Unit (Drs. Bozzali, Cercignani, and Filippi) and the Clinical Trials Unit (Drs. Magnani and Comi), Department of Neuroscience, and the Department of Neuroradiology (Drs. Falini, Pontesilli, and Scotti), Scientific Institute and University H San Raffaele, Milan, Italy; and the Department of Neurology (Dr. Franceschi), H Santa Maria, Castellanza, Italy.
G. Magnani, MD
From the Neuroimaging Research Unit (Drs. Bozzali, Cercignani, and Filippi) and the Clinical Trials Unit (Drs. Magnani and Comi), Department of Neuroscience, and the Department of Neuroradiology (Drs. Falini, Pontesilli, and Scotti), Scientific Institute and University H San Raffaele, Milan, Italy; and the Department of Neurology (Dr. Franceschi), H Santa Maria, Castellanza, Italy.
G. Scotti, MD
From the Neuroimaging Research Unit (Drs. Bozzali, Cercignani, and Filippi) and the Clinical Trials Unit (Drs. Magnani and Comi), Department of Neuroscience, and the Department of Neuroradiology (Drs. Falini, Pontesilli, and Scotti), Scientific Institute and University H San Raffaele, Milan, Italy; and the Department of Neurology (Dr. Franceschi), H Santa Maria, Castellanza, Italy.
G. Comi, MD
From the Neuroimaging Research Unit (Drs. Bozzali, Cercignani, and Filippi) and the Clinical Trials Unit (Drs. Magnani and Comi), Department of Neuroscience, and the Department of Neuroradiology (Drs. Falini, Pontesilli, and Scotti), Scientific Institute and University H San Raffaele, Milan, Italy; and the Department of Neurology (Dr. Franceschi), H Santa Maria, Castellanza, Italy.
M. Filippi, MD
From the Neuroimaging Research Unit (Drs. Bozzali, Cercignani, and Filippi) and the Clinical Trials Unit (Drs. Magnani and Comi), Department of Neuroscience, and the Department of Neuroradiology (Drs. Falini, Pontesilli, and Scotti), Scientific Institute and University H San Raffaele, Milan, Italy; and the Department of Neurology (Dr. Franceschi), H Santa Maria, Castellanza, Italy.

Notes

Address correspondence and reprint requests to Dr. Massimo Filippi, Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute Ospedale San Raffaele, Via Olgettina, 60, 20132 Milan, Italy; e-mail: [email protected]

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