Serial MRI findings in a case of primary lateral sclerosis
Abstract
A patient with primary lateral sclerosis (PLS) underwent MRI 3 times over 8.5 years. These images demonstrate progressive atrophy of the premotor, parietal, and primary sensorimotor cortex, with sparing of the temporal lobe, occipital lobe, and cerebellum. The pattern of cerebral atrophy was clearly restricted but was more extensive than expected from sensorimotor cortex pyramidal cell loss described in literature autopsy reports of PLS. Cortical motor system degeneration in PLS, whether primary or secondary, may be more extensive than previously believed.
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© 2002.
Publication History
Received: June 11, 2001
Accepted: October 31, 2001
Published online: February 26, 2002
Published in print: February 26, 2002
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Cited By
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- Primary lateral sclerosis: a distinct entity or part of the ALS spectrum?, Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 20, 3-4, (133-145), (2019).https://doi.org/10.1080/21678421.2018.1550518
- Hereditary primary lateral sclerosis and progressive nonfluent aphasia, Journal of Neurology, 266, 5, (1079-1090), (2019).https://doi.org/10.1007/s00415-019-09235-x
- Extramotor Damage Is Associated with Cognition in Primary Lateral Sclerosis Patients, PLoS ONE, 8, 12, (e82017), (2013).https://doi.org/10.1371/journal.pone.0082017
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- Brain atrophy in primary lateral sclerosis, Neurology, 72, 14, (1236-1241), (2009)./doi/10.1212/01.wnl.0000345665.75512.f9
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