A randomized trial of botulinum toxin A for treatment of drooling
Abstract
The authors compared the efficacy of three different doses (18.75, 37.5, and 75 MU per parotid gland) of botulinum toxin A (BTX-A; Dysport, Ipsen Pharma, Germany) injections vs vehicle in patients with sialorrhea (n = 32) using a single-center, prospective, double-blind, placebo-controlled dose-finding study. The primary endpoint was achieved with 75 MU BTX-A without treatment-related adverse events, suggesting BTX-A is a safe and effective treatment for patients with sialorrhea.
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Publication History
Received: February 3, 2003
Accepted: July 22, 2003
Published online: November 10, 2003
Published in print: November 11, 2003
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- Onabotulinum Toxin A (BoNT‐A) for Drooling in Children: A Systematic Review and Meta‐Analysis, The Laryngoscope, 134, 7, (3012-3017), (2024).https://doi.org/10.1002/lary.31277
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- Patologie salivari mediche, EMC - Otorinolaringoiatria, 22, 1, (1-18), (2023).https://doi.org/10.1016/S1639-870X(23)47502-2
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- The effectiveness of ultrasound‐guided injection of BTX‐A in the management of sialorrhea in neurogenic dysphagia patients, Laryngoscope Investigative Otolaryngology, 8, 6, (1607-1615), (2023).https://doi.org/10.1002/lio2.1164
- Treatment of sialorrhea in Parkinson’s disease, Annals of Movement Disorders, 5, 3, (153-158), (2022).https://doi.org/10.4103/AOMD.AOMD_9_22
- Therapie der Sialorrhoe mit Botulinumtoxin – ein Update, Fortschritte der Neurologie · Psychiatrie, 90, 05, (222-232), (2022).https://doi.org/10.1055/a-1802-3867
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