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August 7, 2006

The contribution of voxel-based morphometry in staging patients with mild cognitive impairment

M. Bozzali, MD, M. Filippi, MD, G. Magnani, MD, M. Cercignani, MPhil, M. Franceschi, MD, E. Schiatti, MD, S. Castiglioni, Psych, R. Mossini, MD, M. Falautano, Psych, G. Scotti, MD, G. Comi, MD, and A. Falini, MDAuthors Info & Affiliations

August 8, 2006 issue

67 (3) 453-460

https://doi.org/10.1212/01.wnl.0000228243.56665.c2

Abstract

Objective: To assess whether different patterns of regional gray matter loss in patients with mild cognitive impairment (MCI) are associated with different risks of conversion to Alzheimer disease (AD), using MRI and voxel-based morphometry (VBM).

Methods: The authors recruited 22 patients with MCI, 22 patients with probable AD, and 20 healthy subjects (HS). T1 volumes from each subject were postprocessed according to an optimized VBM protocol. All patients were clinically followed up (mean [SD] time = 28.7 [5.7] months), and patients with MCI were reclassified into two groups (converters and nonconverters to AD).

Results: When comparing patients with AD to HS, widespread areas of reduced gray matter density were found predominantly in temporal, frontal, and parietal lobes and in the insula. Comparing MCI converters and nonconverters with HS, the converters showed more widespread areas of reduced gray matter density than nonconverters, with a pattern of abnormalities similar to that seen in patients with AD. Conversely, when comparing the same groups with patients with AD, MCI nonconverters showed a pattern of gray matter density similar to that of HS. Areas of decreased gray matter density were also found in MCI converters compared with nonconverters.

Conclusions: Different patterns of gray matter density distribution in patients with mild cognitive impairment may be associated to different rates of conversion to Alzheimer disease.

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References

1.

Petersen RC, Doody R, Kurz A, et al. Current concepts in mild cognitive impairment. Arch Neurol 2001;58:1985–1992.

2.

Killiany RJ, Moss MB, Albert MS, Sandor T, Tieman J, Jolesz F. Temporal lobe regions on magnetic resonance imaging identify patients with early Alzheimer’s disease. Arch Neurol 1993;50:949–954.

3.

Bobinski M, de Leon MJ, Wegiel J, et al. The histological validation of post mortem magnetic resonance imaging-determined hippocampal volume in Alzheimer’s disease. Neuroscience 2000;95:721–725.

4.

Bottino CM, Castro CC, Gomes RL, Buchpiguel CA, Marchetti RL, Neto MR. Volumetric MRI measurements can differentiate Alzheimer’s disease, mild cognitive impairment, and normal aging. Int Psychogeriatr 2002;14:59–72.

5.

Good CD, Johnsrude IS, Ashburner J, Henson RN, Friston KJ, Frackowiak RS. A voxel-based morphometric study of ageing in 465 normal adult human brains. Neuroimage 2001;14:21–36.

6.

Baron JC, Chetelat G, Desgranges B, et al. In vivo mapping of gray matter loss with voxel-based morphometry in mild Alzheimer’s disease. Neuroimage 2001;14:298–309.

7.

Karas GB, Scheltens P, Rombouts SA, et al. Global and local gray matter loss in mild cognitive impairment and Alzheimer’s disease. Neuroimage 2004;23:708–716.

8.

Chetelat G, Desgranges B, De La Sayette V, Viader F, Eustache F, Baron JC. Mapping gray matter loss with voxel-based morphometry in mild cognitive impairment. Neuroreport 2002;13:1939–1943.

9.

Pennanen C, Testa C, Laakso MP, et al. A voxel based morphometry study on mild cognitive impairment. J Neurol Neurosurg Psychiatry 2005;76:11–14.

10.

Bell-McGinty S, Lopez OL, Meltzer CC, et al. Differential cortical atrophy in subgroups of mild cognitive impairment. Arch Neurol 2005;62:1393–1397.

11.

Chetelat G, Landeau B, Eustache F, et al. Using voxel-based morphometry to map the structural changes associated with rapid conversion in MCI: a longitudinal MRI study. Neuroimage 2005;27:934–946.

12.

Petersen RC, Smith GE, Waring SC, Ivnik RJ, Tangalos EG, Kokmen E. Mild cognitive impairment: clinical characterization and outcome. Arch Neurol 1999;56:303–308.

13.

McKhann G, Drachman D, Folstein M, et al. Clinical diagnosis of Alzheimer’s disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s Disease. Neurology 1984;34:939–944.

14.

Morris JC. The Clinical Dementia Rating (CDR): current version and scoring rules. Neurology 1993;43:2412–2414.

15.

Folstein MF, Folstein SE, McHugh PR. “Mini-Mental State”: a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12:189–198.

16.

Magni E, Binetti G, Bianchetti A, Rozzini R, Trabucchi M. Mini-Mental State examination: a normative study in Italian elderly population. Eur J Neurol 1996;3:1–5.

17.

Novelli G, Papagno C, Capitani E, et al. Tre test clinici di memoria verbale a lungo termine. Arch Psicol Neurol Psich 1986;47:278–296.

18.

Rey A. Reattivo della figura complessa. Firenze: Manuale delle Organizzazioni Speciali, 1983.

19.

Spinnler H, Tognoni G. Standardizzazione e taratura italiana di test neuropsicologici. Ital J Neurol Sci 1987:(suppl 8).

20.

Basso A, Capitani E, Laiacona M. Raven’s coloured progressive matrices: normative values on 305 adult normal controls. Funct Neurol 1987;2:189–194.

21.

Cocosco CA, Kollokian V, Kwan RKS, Evans AC. BrainWeb: online interface to a 3D MRI simulated brain database. NeuroImage 1997;5:S425.

22.

Talairach J, Tournoux P. Co-planar stereotaxic atlas of the human brain. Stuttgart: Thieme, Verlag, 1998.

23.

Luis CA, Barker WW, Loewenstein DA, et al. Conversion to dementia among two groups with cognitive impairment: a preliminary report. Dement Geriatr Cogn Disord 2004;18:307–313.

24.

Herholz K, Salmon E, Perani D, et al. Discrimination between Alzheimer dementia and controls by automated analysis of multicenter FDG PET. Neuroimage 2002;17:302–316.

25.

Drzezga A, Lautenschlager N, Siebner H, et al. Cerebral metabolic changes accompanying conversion of mild cognitive impairment into Alzheimer’s disease: a PET follow-up study. Eur J Nucl Med Mol Imaging 2003;30:1104–1113.

26.

Frey S, Petrides M. Orbitofrontal cortex and memory formation. Neuron 2002;36:171–176.

27.

Ball MJ, Fisman M, Hachinski V, et al. A new definition of Alzheimer’s disease: a hippocampal dementia. Lancet 1985;1:14–16.

28.

Braak H, Braak E. Neuropathological staging of Alzheimer-related changes. Acta Neuropathol 1991;82:239–259.

29.

Bozzali M, Franceschi M, Falini A, et al. Quantification of tissue damage in AD using diffusion tensor and magnetization transfer MRI. Neurology 2001;57:1135–1137.

30.

Bozzali M, Falini A, Franceschi M, et al. White matter damage in Alzheimer’s disease assessed in vivo using diffusion tensor magnetic resonance imaging. J Neurol Neurosurg Psychiatry 2002;72:742–746.

Information & Authors

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Published In

Neurology^®

Volume 67 • Number 3 • August 8, 2006

Pages: 453-460

PubMed: 16894107

Copyright

© 2006.

Publication History

Published online: August 7, 2006

Published in print: August 8, 2006

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Authors

Affiliations & Disclosures

M. Bozzali, MD

From the Neuroimaging Research Unit (M.B., M. Filippi, M.C.), Department of Neurology (M. Filippi, G.M., E.S., R.M., M. Falautano, G.C.), and Department of Neuroradiology, CERMAC (G.S., A.F.), Scientific Institute and University Ospedale San Raffaele, Milan, Italy; Wellcome Department of Imaging Neuroscience (M.B.) and NMR Research Unit (M.C.), Institute of Neurology, University College of London, London, UK; and Department of Neurology, Multimedica-SantaMaria, Castellanza, Italy (M. Franceschi, S.C.).

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M. Filippi, MD

From the Neuroimaging Research Unit (M.B., M. Filippi, M.C.), Department of Neurology (M. Filippi, G.M., E.S., R.M., M. Falautano, G.C.), and Department of Neuroradiology, CERMAC (G.S., A.F.), Scientific Institute and University Ospedale San Raffaele, Milan, Italy; Wellcome Department of Imaging Neuroscience (M.B.) and NMR Research Unit (M.C.), Institute of Neurology, University College of London, London, UK; and Department of Neurology, Multimedica-SantaMaria, Castellanza, Italy (M. Franceschi, S.C.).

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G. Magnani, MD

From the Neuroimaging Research Unit (M.B., M. Filippi, M.C.), Department of Neurology (M. Filippi, G.M., E.S., R.M., M. Falautano, G.C.), and Department of Neuroradiology, CERMAC (G.S., A.F.), Scientific Institute and University Ospedale San Raffaele, Milan, Italy; Wellcome Department of Imaging Neuroscience (M.B.) and NMR Research Unit (M.C.), Institute of Neurology, University College of London, London, UK; and Department of Neurology, Multimedica-SantaMaria, Castellanza, Italy (M. Franceschi, S.C.).

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M. Cercignani, MPhil

From the Neuroimaging Research Unit (M.B., M. Filippi, M.C.), Department of Neurology (M. Filippi, G.M., E.S., R.M., M. Falautano, G.C.), and Department of Neuroradiology, CERMAC (G.S., A.F.), Scientific Institute and University Ospedale San Raffaele, Milan, Italy; Wellcome Department of Imaging Neuroscience (M.B.) and NMR Research Unit (M.C.), Institute of Neurology, University College of London, London, UK; and Department of Neurology, Multimedica-SantaMaria, Castellanza, Italy (M. Franceschi, S.C.).

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M. Franceschi, MD

From the Neuroimaging Research Unit (M.B., M. Filippi, M.C.), Department of Neurology (M. Filippi, G.M., E.S., R.M., M. Falautano, G.C.), and Department of Neuroradiology, CERMAC (G.S., A.F.), Scientific Institute and University Ospedale San Raffaele, Milan, Italy; Wellcome Department of Imaging Neuroscience (M.B.) and NMR Research Unit (M.C.), Institute of Neurology, University College of London, London, UK; and Department of Neurology, Multimedica-SantaMaria, Castellanza, Italy (M. Franceschi, S.C.).

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E. Schiatti, MD

From the Neuroimaging Research Unit (M.B., M. Filippi, M.C.), Department of Neurology (M. Filippi, G.M., E.S., R.M., M. Falautano, G.C.), and Department of Neuroradiology, CERMAC (G.S., A.F.), Scientific Institute and University Ospedale San Raffaele, Milan, Italy; Wellcome Department of Imaging Neuroscience (M.B.) and NMR Research Unit (M.C.), Institute of Neurology, University College of London, London, UK; and Department of Neurology, Multimedica-SantaMaria, Castellanza, Italy (M. Franceschi, S.C.).

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S. Castiglioni, Psych

From the Neuroimaging Research Unit (M.B., M. Filippi, M.C.), Department of Neurology (M. Filippi, G.M., E.S., R.M., M. Falautano, G.C.), and Department of Neuroradiology, CERMAC (G.S., A.F.), Scientific Institute and University Ospedale San Raffaele, Milan, Italy; Wellcome Department of Imaging Neuroscience (M.B.) and NMR Research Unit (M.C.), Institute of Neurology, University College of London, London, UK; and Department of Neurology, Multimedica-SantaMaria, Castellanza, Italy (M. Franceschi, S.C.).

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R. Mossini, MD

From the Neuroimaging Research Unit (M.B., M. Filippi, M.C.), Department of Neurology (M. Filippi, G.M., E.S., R.M., M. Falautano, G.C.), and Department of Neuroradiology, CERMAC (G.S., A.F.), Scientific Institute and University Ospedale San Raffaele, Milan, Italy; Wellcome Department of Imaging Neuroscience (M.B.) and NMR Research Unit (M.C.), Institute of Neurology, University College of London, London, UK; and Department of Neurology, Multimedica-SantaMaria, Castellanza, Italy (M. Franceschi, S.C.).

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M. Falautano, Psych

From the Neuroimaging Research Unit (M.B., M. Filippi, M.C.), Department of Neurology (M. Filippi, G.M., E.S., R.M., M. Falautano, G.C.), and Department of Neuroradiology, CERMAC (G.S., A.F.), Scientific Institute and University Ospedale San Raffaele, Milan, Italy; Wellcome Department of Imaging Neuroscience (M.B.) and NMR Research Unit (M.C.), Institute of Neurology, University College of London, London, UK; and Department of Neurology, Multimedica-SantaMaria, Castellanza, Italy (M. Franceschi, S.C.).

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G. Scotti, MD

From the Neuroimaging Research Unit (M.B., M. Filippi, M.C.), Department of Neurology (M. Filippi, G.M., E.S., R.M., M. Falautano, G.C.), and Department of Neuroradiology, CERMAC (G.S., A.F.), Scientific Institute and University Ospedale San Raffaele, Milan, Italy; Wellcome Department of Imaging Neuroscience (M.B.) and NMR Research Unit (M.C.), Institute of Neurology, University College of London, London, UK; and Department of Neurology, Multimedica-SantaMaria, Castellanza, Italy (M. Franceschi, S.C.).

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G. Comi, MD

From the Neuroimaging Research Unit (M.B., M. Filippi, M.C.), Department of Neurology (M. Filippi, G.M., E.S., R.M., M. Falautano, G.C.), and Department of Neuroradiology, CERMAC (G.S., A.F.), Scientific Institute and University Ospedale San Raffaele, Milan, Italy; Wellcome Department of Imaging Neuroscience (M.B.) and NMR Research Unit (M.C.), Institute of Neurology, University College of London, London, UK; and Department of Neurology, Multimedica-SantaMaria, Castellanza, Italy (M. Franceschi, S.C.).

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A. Falini, MD

From the Neuroimaging Research Unit (M.B., M. Filippi, M.C.), Department of Neurology (M. Filippi, G.M., E.S., R.M., M. Falautano, G.C.), and Department of Neuroradiology, CERMAC (G.S., A.F.), Scientific Institute and University Ospedale San Raffaele, Milan, Italy; Wellcome Department of Imaging Neuroscience (M.B.) and NMR Research Unit (M.C.), Institute of Neurology, University College of London, London, UK; and Department of Neurology, Multimedica-SantaMaria, Castellanza, Italy (M. Franceschi, S.C.).

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Notes

Address correspondence and reprint requests to Dr. Marco Bozzali, Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College of London, 12 Queen Square, WC1N 3BG London, UK; e-mail: [email protected]

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