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Research Article
May 11, 2022
Open Accessnull hypothesisinfographiccontinuing medical education

Maternal Serotonergic Antidepressant Use in Pregnancy and Risk of Seizures in Children

June 7, 2022 issue
98 (23) e2329-e2336
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Can Maternal Serotonergic Antidepressant Use Increase the Risk of Seizures in Children?
Letters to the Editor

Information & Authors

Information

Published In

Neurology®
Volume 98Number 23June 7, 2022
Pages: e2329-e2336
PubMed: 35545445

Publication History

Received: August 24, 2021
Accepted: February 28, 2022
Published online: May 11, 2022
Published in print: June 7, 2022

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Disclosure

H. Larsson has served as a speaker for Eli Lilly and Shire and has received research grants from Shire, all outside the submitted work. The other authors have no disclosures to report. Go to Neurology.org/N for full disclosures.

Study Funding

This project was supported by the National Institute of Neurologic Disorders and Stroke (F31NS111856), National Institute of Mental Health (T32MH103213), National Institute on Drug Abuse of the NIH (R01DA048042 and R00DA040727), the National Science Foundation (1342962), the Swedish Research Council, and the Swedish Research Council for Health, Working Life and Welfare (FORTE; 50623213). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.

Authors

Affiliations & Disclosures

Kelsey Kathleen Wiggs, BS, BA* https://orcid.org/0000-0002-8013-7925
From the Department of Psychological & Brain Sciences (K.K.W., M.E.R., B.M.D.) and Department of Applied Health Science, School of Public Health (P.D.Q.), Indiana University, Bloomington; Kaiser Permanente Northern California Division of Research (A.C.S.), Oakland; Department of Medical Epidemiology and Biostatistics (H.L., P.L., B.M.D., A.S.O.), Karolinska Institutet, Stockholm; School of Medical Sciences (H.L.), Örebro University, Sweden; and Department of Epidemiology (A.S.O.), T.H. Chan School of Public Health, Harvard, Boston, MA.
Disclosure
Scientific Advisory Boards:
1.
None
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
<br>(1) Zambon, speaker honoraria and travel expenses<br>(2) Bial, speaker honoraria<br>
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NONE
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
None
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
Ayehsa C. Sujan, PhD*
From the Department of Psychological & Brain Sciences (K.K.W., M.E.R., B.M.D.) and Department of Applied Health Science, School of Public Health (P.D.Q.), Indiana University, Bloomington; Kaiser Permanente Northern California Division of Research (A.C.S.), Oakland; Department of Medical Epidemiology and Biostatistics (H.L., P.L., B.M.D., A.S.O.), Karolinska Institutet, Stockholm; School of Medical Sciences (H.L.), Örebro University, Sweden; and Department of Epidemiology (A.S.O.), T.H. Chan School of Public Health, Harvard, Boston, MA.
Disclosure
Scientific Advisory Boards:
1.
None
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
<br>(1) Zambon, speaker honoraria and travel expenses<br>(2) Bial, speaker honoraria<br>
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NONE
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
None
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
Martin E. Rickert, PhD
From the Department of Psychological & Brain Sciences (K.K.W., M.E.R., B.M.D.) and Department of Applied Health Science, School of Public Health (P.D.Q.), Indiana University, Bloomington; Kaiser Permanente Northern California Division of Research (A.C.S.), Oakland; Department of Medical Epidemiology and Biostatistics (H.L., P.L., B.M.D., A.S.O.), Karolinska Institutet, Stockholm; School of Medical Sciences (H.L.), Örebro University, Sweden; and Department of Epidemiology (A.S.O.), T.H. Chan School of Public Health, Harvard, Boston, MA.
Disclosure
Scientific Advisory Boards:
1.
None
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
<br>(1) Zambon, speaker honoraria and travel expenses<br>(2) Bial, speaker honoraria<br>
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NONE
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
None
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
Patrick D. Quinn, PhD
From the Department of Psychological & Brain Sciences (K.K.W., M.E.R., B.M.D.) and Department of Applied Health Science, School of Public Health (P.D.Q.), Indiana University, Bloomington; Kaiser Permanente Northern California Division of Research (A.C.S.), Oakland; Department of Medical Epidemiology and Biostatistics (H.L., P.L., B.M.D., A.S.O.), Karolinska Institutet, Stockholm; School of Medical Sciences (H.L.), Örebro University, Sweden; and Department of Epidemiology (A.S.O.), T.H. Chan School of Public Health, Harvard, Boston, MA.
Disclosure
Scientific Advisory Boards:
1.
None
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
<br>(1) Zambon, speaker honoraria and travel expenses<br>(2) Bial, speaker honoraria<br>
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NONE
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
None
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
Henrik Larsson, PhD
From the Department of Psychological & Brain Sciences (K.K.W., M.E.R., B.M.D.) and Department of Applied Health Science, School of Public Health (P.D.Q.), Indiana University, Bloomington; Kaiser Permanente Northern California Division of Research (A.C.S.), Oakland; Department of Medical Epidemiology and Biostatistics (H.L., P.L., B.M.D., A.S.O.), Karolinska Institutet, Stockholm; School of Medical Sciences (H.L.), Örebro University, Sweden; and Department of Epidemiology (A.S.O.), T.H. Chan School of Public Health, Harvard, Boston, MA.
Disclosure
Scientific Advisory Boards:
1.
None
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
<br>(1) Zambon, speaker honoraria and travel expenses<br>(2) Bial, speaker honoraria<br>
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NONE
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
None
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
Paul Lichtenstein, PhD
From the Department of Psychological & Brain Sciences (K.K.W., M.E.R., B.M.D.) and Department of Applied Health Science, School of Public Health (P.D.Q.), Indiana University, Bloomington; Kaiser Permanente Northern California Division of Research (A.C.S.), Oakland; Department of Medical Epidemiology and Biostatistics (H.L., P.L., B.M.D., A.S.O.), Karolinska Institutet, Stockholm; School of Medical Sciences (H.L.), Örebro University, Sweden; and Department of Epidemiology (A.S.O.), T.H. Chan School of Public Health, Harvard, Boston, MA.
Disclosure
Scientific Advisory Boards:
1.
None
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
<br>(1) Zambon, speaker honoraria and travel expenses<br>(2) Bial, speaker honoraria<br>
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NONE
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
None
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
Brian M. D'Onofrio, PhD
From the Department of Psychological & Brain Sciences (K.K.W., M.E.R., B.M.D.) and Department of Applied Health Science, School of Public Health (P.D.Q.), Indiana University, Bloomington; Kaiser Permanente Northern California Division of Research (A.C.S.), Oakland; Department of Medical Epidemiology and Biostatistics (H.L., P.L., B.M.D., A.S.O.), Karolinska Institutet, Stockholm; School of Medical Sciences (H.L.), Örebro University, Sweden; and Department of Epidemiology (A.S.O.), T.H. Chan School of Public Health, Harvard, Boston, MA.
Disclosure
Scientific Advisory Boards:
1.
None
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
<br>(1) Zambon, speaker honoraria and travel expenses<br>(2) Bial, speaker honoraria<br>
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NONE
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
None
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE
From the Department of Psychological & Brain Sciences (K.K.W., M.E.R., B.M.D.) and Department of Applied Health Science, School of Public Health (P.D.Q.), Indiana University, Bloomington; Kaiser Permanente Northern California Division of Research (A.C.S.), Oakland; Department of Medical Epidemiology and Biostatistics (H.L., P.L., B.M.D., A.S.O.), Karolinska Institutet, Stockholm; School of Medical Sciences (H.L.), Örebro University, Sweden; and Department of Epidemiology (A.S.O.), T.H. Chan School of Public Health, Harvard, Boston, MA.
Disclosure
Scientific Advisory Boards:
1.
None
Gifts:
1.
NONE
Funding for Travel or Speaker Honoraria:
1.
<br>(1) Zambon, speaker honoraria and travel expenses<br>(2) Bial, speaker honoraria<br>
Editorial Boards:
1.
NONE
Patents:
1.
NONE
Publishing Royalties:
1.
NONE
Employment, Commercial Entity:
1.
NONE
Consultancies:
1.
NONE
Speakers' Bureaus:
1.
NONE
Other Activities:
1.
NONE
Clinical Procedures or Imaging Studies:
1.
NONE
Research Support, Commercial Entities:
1.
NONE
Research Support, Government Entities:
1.
NONE
Research Support, Academic Entities:
1.
NONE
Research Support, Foundations and Societies:
1.
None
Stock/stock Options/board of Directors Compensation:
1.
NONE
License Fee Payments, Technology or Inventions:
1.
NONE
Royalty Payments, Technology or Inventions:
1.
NONE
Stock/stock Options, Research Sponsor:
1.
NONE
Stock/stock Options, Medical Equipment & Materials:
1.
NONE
Legal Proceedings:
1.
NONE

Notes

Correspondence K.K. Wiggs [email protected]
Go to Neurology.org/N for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.
*
These authors contributed equally as co–first authors.
The Article Processing Charge was funded by the Swedish Research Council.
Submitted and externally peer reviewed. The handling editor was Renee Shellhaas, MD, MS.
This Null Hypothesis article is published as part of a collaborative effort, between Neurology and CBMRT.

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  1. Maternal treatment with selective serotonin reuptake inhibitors during pregnancy and delayed neonatal adaptation: a population-based cohort study, Archives of Disease in Childhood - Fetal and Neonatal Edition, (fetalneonatal-2023-326049), (2023).https://doi.org/10.1136/archdischild-2023-326049
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