Innovations in Care Delivery

Editors' Blog

  • Outcome Measures for Premanifest Alzheimer Disease Trials
    By Albin Rogers, MD and Vikas Kotagal, MD, MS

     

    The outcomes of pivotal trials for disease-modifying therapies in Alzheimer disease (AD) have been very disappointing. One plausible explanation for trial failure is that treating manifest AD subjects is too late. There is considerable neurodegeneration at clinical disease onset. Ab-amyloid accumulation begins many years prior to clinical disease onset with cerebral Ab-amyloid burden high in emerging dementia. These features may account for the failure, in particular, of interventions aimed at reducing generation of or burden of Ab-amyloid.

    Continued...

    July 16, 2019
    View Blog Site

Latest Articles

Show more

  • Interview With A Health Services Expert

    Dr. Kevin Kerber interviews Dr. Ralph Sacco  

    Dr. Sacco talks about his leadership role in balancing the needs of neurologists, the department and other stake holders with the needs of patients. He outlines successful approaches to improving patient access to quality care, the challenges in implementing these approaches, and what he sees as the future in care delivery .

    In April of 2017, Drs. Kerber and Callaghan had the chance to talk to Ralph L. Sacco, MD, MS, University of Miami Miller School of Medicine where Dr. Sacco is  Chairman & Professor Department of Neurology, Director and Principal Investigator of the University of Miami Clinical and Translational Science Institute, Executive Director Evelyn F McKnight Brain Institute, Miller Professor of Epidemiology, Public Health Sciences, Human Genetics, and Neurosurgery, Olemberg Family Chair in Neurological Disorders and Senior Associate Dean for Clinical & Translational Science. Dr. Sacco is also the President of the American Academy of Neurology.

    Sacco image

    N A M E: Ralph L. Sacco, MD, MS, FAHA, FAAN
    T I T L E: Chairman & Professor Department of Neurology; Director and  Principal Investigator of the University of Miami Clinical and Translational Science Institute; Executive Director Evelyn F McKnight Brain Institute; Miller Professor of Epidemiology, Public Health Sciences, Human Genetics, and Neurosurgery; Olemberg Family Chair in Neurological Disorders; and Senior Associate Dean for Clinical & Translational Science.
    E D U C A T I O N: Dr. Sacco is a graduate of Cornell University and graduated cum laude from Boston University School of Medicine. He holds a master’s in epidemiology from Columbia University, School of Public Health and completed his residency training and postdoctoral training in stroke and epidemiology at New York’s Columbia Presbyterian.
    H O B B I E S: Renovating homes in NY, biking, and volunteer work.

    INTERVIEW Audio

    FUll transcript of interview

     A  R  C  H  I  V  E  S 

Podcasts

Advertisement
  • Call to Action!

    ​Neurology: Clinical Practice has launched their next Practice Current survey on a universally controversial topic —Practice Current: How do you manage patients with a "hot carotid"? Please consider completing the survey to add your own perspective.

    ​An important perspective about new medical equipment in low resource countries -  Dr. Omar Siddiqi, Assistant Professor of Neurology at Harvard Medical School and the Director of the Global Neurology Program at Beth Israel Deaconess Medical Center, shares his experiences with the unforeseen negatives to innovative, medical technology in resource limited settings. He states, 'Near as I can tell, the only purpose they serve is to charge patients for a sham test.’ ”  

     

  • About The Editors

    Callaghan Image

    Editor, Innovations in Care Delivery
    Brian C. Callaghan, MD, MS
    Ann Arbor, MI

    Biography

     

    Kerber image

    Editor, Innovations in Care Delivery
    Kevin A. Kerber, MD, MS
    Ann Arbor MI

    Biography