Most Cited Articles
Objective: The contemporary diagnosis of paraneoplastic neurologic syndromes (PNSs) requires
an increasing understanding of their clinical, immunologic, and oncologic heterogeneity.
The 2004 PNS criteria are partially outdated due to advances in PNS ...
Objective: Autoimmune encephalitis (AE) is an important and treatable cause of acute encephalitis.
Diagnosis of AE in a developing child is challenging because of overlap in clinical
presentations with other diseases and complexity of normal behavior ...
Although often regarded as a protean illness with myriad clinical and imaging manifestations,
neurosarcoidosis typically presents as recognizable syndromes that can be approached
in a rational, systematic fashion. Understanding of neurosarcoidosis has ...
Objective: To describe the features of adult patients with benign, unilateral cerebral cortical
encephalitis positive for the myelin oligodendrocyte glycoprotein (MOG) antibody. Methods: In this retrospective, cross-sectional study, after we encountered an ...
Background and Objectives: Recovery from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection
appears exponential, leaving a tail of patients reporting various long COVID symptoms
including unexplained fatigue/exertional intolerance and ...
Objective: To compare the reproducibility of 11 antibody assays for immunoglobulin (Ig) G and
IgM myelin oligodendrocyte glycoprotein antibodies (MOG-IgG and MOG-IgM) from 5 international
centers. Methods: The following samples were analyzed: MOG-IgG clearly ...
Neuromyelitis optica spectrum disorder (NMOSD) is a rare autoimmune disorder that
preferentially affects the spinal cord and optic nerve. Most patients with NMOSD experience
severe relapses that lead to permanent neurologic disability; therefore, limiting
...
Background and Objectives: Neurodegeneration and astrocytic activation are pathologic hallmarks of progressive
multiple sclerosis (MS) and can be quantified by serum neurofilament light chain (sNfL)
and glial fibrillary acidic protein (sGFAP). We ...
Objective: Antibodies against glutamic acid decarboxylase 65 (anti-GAD65) are associated with
a number of neurologic syndromes. However, their pathogenic role is controversial.
Our objective was to describe clinical and paraclinical characteristics of anti-...
Objective: To optimize sensitivity and disease specificity of a myelin oligodendrocyte glycoprotein
(MOG) antibody assay. Methods: Consecutive sera (n = 1,109) sent for aquaporin-4 (AQP4) antibody testing were screened
for MOG antibodies (Abs) by cell-based ...
Objective: To create an international consensus treatment recommendation for pediatric NMDA receptor
antibody encephalitis (NMDARE). Methods: After selection of a panel of 27 experts with representation from all continents,
a 2-step Delphi method was adopted ...
Background and Objectives: To determine the real-world use of rituximab in autoimmune encephalitis (AE) and to
correlate rituximab treatment with the long-term outcome. Methods: Patients with NMDA receptor (NMDAR)-AE, leucine-rich glioma-inactivated-1 (LGI1)-
...
Objective: To describe the phenotypes, treatment response, and outcome of IgLON5 autoimmunity. Methods: Archived serum and CSF specimens from 367 patients known to harbor unclassified antibodies
which stained neural synapses diffusely (mimicking amphiphysin-...
Objective: To investigate whether visual disability which is known to accumulate by poor recovery
from optic neuritis (ON) attacks can be lessened by early treatment, we investigated
whether the time from symptom onset to high-dose IV methylprednisolone (...
Objective: To analyze whether 1 of the 2 apheresis techniques, therapeutic plasma exchange (PE)
or immunoadsorption (IA), is superior in treating neuromyelitis optica spectrum disorder
(NMOSD) attacks and to identify predictive factors for complete ...
Objective: To report the induction of anti–Ma2 antibody–associated paraneoplastic neurologic
syndrome (Ma2-PNS) in 6 patients after treatment with immune checkpoint inhibitors
(ICIs). We also analyzed (1) patient clinical features compared with a cohort of ...
Background and Objectives: To evaluate the long-term safety and efficacy of tocilizumab (TCZ), a humanized anti–interleukin-6
receptor antibody in myelin oligodendrocyte glycoprotein–IgG–associated disease (MOGAD)
and neuromyelitis optica spectrum disorders ...
Background and Objectives: Chronic active lesions contribute to multiple sclerosis (MS) severity, but their association
with long-term disease progression has not been evaluated yet. White matter (WM) lesions
showing linear expansion over time on serial T1- ...
Objective: To determine the observed and expected incidence rates of paraneoplastic neurologic
syndromes (PNSs) and autoimmune encephalitides (AEs) diagnosed in France between 2016
and 2018, we conducted a population-based epidemiologic study. Methods: ...
Background and Objectives: Since the onset of the COVID-19 pandemic, a growing number of reports have described
cases of acute disseminated encephalomyelitis (ADEM) and acute hemorrhagic leukoencephalitis
(AHLE) following infection with COVID-19. Given ...
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