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COVID Vaccines and Neurology Immunotherapy; Health Disparities in Stroke Interventions

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The December 2021 replay of past episodes showcases a selection of interviews regarding the diagnosis and management of stroke. This episode features Dr. Andy Southerland and Will Rondeau in conversation with Drs. Seemant Chaturvedi, Lee Schwamm, Jyri Virta, and Sidsel Hastrup, offering listeners a review across the field of vascular neurology.

Disclosures can be found at Neurology.org.

November 30, 2021 Issue

In the first part of the podcast, Dr. Stacey Clardy talks with Dr. Christopher Klein about small fiber neuropathy incidence, prevalence, longitudinal impairments, and disabilities (00:45). In the second segment, Dr. Amy Guzik discusses the representation of women in stroke clinical trials relative to the burden of disease in the population with Dr. Cheryl Carcel (16:12).

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology® Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by completing the online podcast quiz.

Neurologic Safety of COVID-19 Vaccines; Movement Disorders in Anti-IgLON5 Disease

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In the first part of the podcast, Dr. Alberto Espay talks with Prof. Julian Gillmore about CRISPR-Cas9 in vivo gene editing for transthyretin amyloidosis. In the second segment, Dr. Pearce Korb discusses the long-term outcomes of osmotic demyelination syndrome in an updated cohort with Dr. Whitney Fitts.

Disclosures can be found at Neurology.org.

No CME this week: Interviews based on articles from Neurology® Clinical Practice, Neurology® Genetics, and Neurology® Neuroimmunology & Neuroinflammation are excluded from the CME program.

October 5, 2021 Issue

Out-of-Pocket Costs for MS Drugs; Part 4 of the Thunderclap Headache Series

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In the first segment, Dr. Jason Crowell talks with Dr. Paul Ford about patient perceptions of the FDA approval process for disease modifying therapies in people living with multiple sclerosis. In the second part of the podcast, Dr. Teshamae Monteith discusses the management of cerebral aneurysm with Dr. Dileep Yavagal in the third part of our four-part series on thunderclap headache.

Disclosures can be found at Neurology.org.

No CME this week: Interviews based on articles from Neurology® Clinical Practice, Neurology® Genetics, and Neurology® Neuroimmunology & Neuroinflammation are excluded from the CME program.

SPECIAL REPORT: A Discussion With Mary Post (Part 2)

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History of the Neurologic Exam (Neurology Recall May 2021)

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In the first segment, Dr. Jeff Burns speaks with Prof. Maria Eriksdotter about whether Cholinesterase inhibitors are associated with slower cognitive decline and decreased mortality risk. In the second part of the podcast, the interviewer talks with Dr. Martijn Wijburg about pharmacovigilance of patients treated with disease-modifying therapies for MS.

Disclosures can be found at Neurology.org.

April 22, 2021 Issue

Dr. Derek Stitt speaks with FDA Center for Biologics Evaluation and Research Director Dr. Peter Marks about cases of thrombosis after the Johnson & Johnson COVID-19 vaccine, potential risk factors, and suggestions for patient care.

Disclosures can be found at Neurology.org.

Chronic Immune Sensory Polyradiculopathy; Ethical Issues in Neurology Research

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In the first segment, the interviewer talks with Dr. Nicolas Collongues about pregnancy in patients with neuromyelitis optica spectrum disorder. In the second part of the podcast, Dr. Jason Crowell discusses racial and ethnic health disparities exacerbated by COVID-19 with Drs. Leo Lopez III and Louis Hart.

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology® Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by completing the online podcast quiz.

April 6, 2021 Issue

In the first segment, Dr. Stacey Clardy talks to Jade Smith about financial conflicts of interest of authors published in high-impact neurology journals. In the second part of the podcast, Dr. Jason Crowell speaks with Dr. Emily Largent about potential advancements and ethical challenges associated with blood testing for Alzheimer disease.

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology® Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by completing the online podcast quiz.

SPECIAL REPORT: Patients’ out of pocket costs in neurology

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Podcast founding editor Dr. Ted Burns introduces our Neurology Recall on Parkinson disease (PD), which features short segments discussing non-motor clinical manifestations, treatment options for motor manifestations, and recent advances in PD. This is a compilation of contributions to the Neurology Minute™ from the past 22 months since its launch in February 2019.

Disclosures can be found at Neurology.org.

December 29, 2020 Issue

Dr. Avi Nath discusses update on the vaccines, how things are going in schools, and what we might expect in 2021.

Disclosures can be found at Neurology.org.

December 22, 2020 Issue

Dr. Avi Nath discusses update on the vaccines, how things are going in schools, and what we might expect in 2021.

Disclosures can be found at Neurology.org.

December 16, 2020 Issue

Drs. Monteith and Silberstein discuss all the new medications, and how and when to use them.

Disclosures can be found at Neurology.org.

Gender Representation in AAN Leadership, Publication, and Awards; Posterior Cortical Atrophy

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In the first segment, Dr. Teshamae Monteith talks with Dr. Janis Miyasaki about gender representation in AAN leadership, publication, and awards. In the second part of the podcast, Dr. Jason Crowell speaks with journalist Jamie Talan about posterior cortical atrophy.

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by completing the online Podcast quiz.

Framing Discussions on Palliative Care in Neurology; Diagnosing Functional Neurologic Disorders

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In the first segment, the interviewer talks with Dr. April Zehm about her Neurology: Clinical Practice paper regarding Framing Discussions on Palliative Care in Neurology. In the second part of the podcast, you’ll hear an interview with Dr. David Perez on Diagnosing Functional Neurologic Disorders.  

Disclosures can be found at Neurology.org.

No CME this week: Interviews based on articles from Neurology: Clinical Practice®, Neurology® Genetics, and Neurology® Neuroimmunology & Neuroinflammation are excluded from the CME program.

December 2, 2020 Issue

This month's replay of past episodes features talks to help with the basics of treatment and prevention of stroke. This month highlights 3 segments featuring Dr. Dan Ackerman talking with Dr. Andrew Southerland, in a comprehensive talk on the care of stroke patients. Here are some questions and topics you might want to discuss at your journal club after you have listened to the November 2020 (1 &2) and December (3, 4 & 5) 2020 Neurology Recall on Stroke Management.

Disclosures can be found at Neurology.org.

December 1, 2020 Issue

In the first segment, Dr. Stacey Clardy talks with Dr. Roy Freeman about his paper discussing idiopathic distal sensory polyneuropathy. In the second part of the podcast, Dr. Clardy talks with Dr. Justin McArthur about his research, work, and the National Academy of Medicine Award.

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by completing the online Podcast quiz

In the first segment, Dr. Jason Crowell talks with Dr. Jennifer Shum about her paper on neural correlates of sign language production. In the second part of the podcast, the interviewer speaks with Dr. Matthew Stuart Robbins on the Headache Quality Measurement Set.  

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by completing the online Podcast quiz

In the first segment, Dr. Jason Crowell speaks with Dr. Martha Barnette of the 'A Way with Words' podcast about language, words, and neurology. In the second part of the podcast, Dr. Jeffrey Ratliff talks with Dr. Bonnie Scott about her paper on apathy and impulse control disorders in Parkinson's disease.  

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by completing the online Podcast quiz.

November 15, 2020 Issue

SPECIAL REPORT: Changing Neurology Education

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In the first segment, Dr. Jeff Burns talks with Dr. Yvette Sheline about her paper on the Effect of escitalopram on CSF Aβ. In the second part of the podcast, Dr. Stacey Clardy speaks with Dr. Elizabeth Finger about her article on the neural effects of oxytocin on frontotemporal dementia, also from this week’s issue. 

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by completing the online Podcast quiz.

In the first segment, Dr. Derek Bauer talks with Dr. Christoph Beier about his paper on predicting treatment response in generalized epilepsy. In the second part of the podcast, the interviewer speaks with Dr. Diego Kaski about his Brain article on dissociated motor learning in functional gait disorders. Read the article here: https://bit.ly/36JjFOP.  

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by completing the online Podcast quiz.

This month's replay of past episodes features talks to help with the basics of treatment and prevention of stroke. This month highlights 2 segments featuring Dr. Dan Ackerman talking with Dr. Andrew Southerland, in a comprehensive talk on the care of stroke patients. 

Disclosures can be found at Neurology.org.

In the first segment, Dr. Jeff Burns speaks with Dr. Michael Weiner about his New York Times article on blood tests for Alzheimer’s disease. Read the NYT article here: https://nyti.ms/3cKheMW. Next, the interviewer talks with Dr. Martin Monti about his Neurology Journal paper on subcortical involvement in traumatic brain injury. 

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by completing the online Podcast quiz.

In the first segment, Dr. Jeffrey Ratliff talks with Dr. Elizabeth Matthews about her paper on super-refractory status epilepticus. In the second part of the podcast, Dr. Jason Crowell speaks with Matthew Futterman about his New York Times article on neurologic sequela in sledding athletes. Read the NYT article here: https://nyti.ms/3mNBlhE. 

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by completing the online Podcast quiz.

In the first segment, Dr. Jeffrey Ratliff speaks with Dr. A.M. Madelein van der Stouwe about her Journal of Neurology, Neurosurgery, and Psychiatry article on diagnosing arm tremor. Read the article here: https://bit.ly/3iETrQD. In the second part of the podcast, Dr. Andrew Southerland talks with Dr. Michael Knoflach and Dr. Lukas Mayer about their paper discussing extracellular matrix protein in cervical artery dissection. 

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by completing the online Podcast quiz.

In the first segment, Dr. Jason Crowell continues his discussion with Dr. Sonia Vallabh on a profile of prion disease, in the second part of a 2-part interview. Next, the interviewer talks with Dr. Amit Bar-Or about his paper discussing vaccine response in patients with MS.

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by completing the online Podcast quiz.

October 1, 2020 Issue

In this month's replay of past episodes, we cover movement disorder emergencies, featuring discussion between podcast editors Dr. Jeffrey Ratliff and Dr. Jason Crowell, from July 13th and 20th. For discussion questions for your next journal club talk, go here.

Disclosures can be found at Neurology.org.

September 29, 2020 Issue

In the first part of the podcast, Dr. Jason Crowell speaks with Dr. Sonia Vallabh about her life and work in prion disease, in the 1st part of a 2-part series. Dr. Vallabh has been profiled in WIRED and the New York Times. Next, Dr. Teshamae Monteith talks with Dr. Joanne Fielding about her paper discussing visual processing in visual snow syndrome.

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by completing the online Podcast quiz.

In the first segment, Dr. Jason Crowell talks with Eric Pachman about his report on copaxone and drug pricing. Next, Dr. Jeffrey Ratliff talks with Dr. Yi Li about her Neurology: Clinical Practice paper discussing ultrasound-guided lumbar puncture. 

Disclosures can be found at Neurology.org.

No CME this week: Interviews based on articles from Neurology: Clinical Practice®, Neurology® Genetics, and Neurology® Neuroimmunology & Neuroinflammation are excluded from the CME program.

In the first segment, Dr. Dan Ackerman and Dr. Andrew Southerland finish their discussion on managing ischemic stroke, in the 5th of a 5-part series. Next up, Dr. Stacey Clardy talks with Dr. Luise Appeltshauser about her paper discussing paranodal antibodies in acute autoimmune neuropathy. 

Disclosures can be found at Neurology.org.

No CME this week: Interviews based on articles from Neurology: Clinical Practice®, Neurology® Genetics, and Neurology® Neuroimmunology & Neuroinflammation are excluded from the CME program.

Dr. Dan Ackerman and Dr. Andrew Southerland continue their discussion on managing ischemic stroke, in the 4th of a 5-part series. Dr. Jason Crowell talks with Dr. Lara Jehi about her paper discussing surgery costs in temporal lobe epilepsy.

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

In this month's replay of past episodes, we cover treatment and management of status epilepticus, featuring discussion between Dr. Halley Alexander and Dr. Michael Sperling. For discussion questions for your next journal club talk, go here. 

Disclosures can be found at Neurology.org.

Dr. Dan Ackerman and Dr. Andrew Southerland continue their discussion on managing ischemic stroke, in the 3rd of a 5-part series. In the second segment, Dr. Halley Alexander talks with Dr. Martha Morrell about her paper discussing neurostimulation in focal epilepsy.

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

In the 2nd of a 5-part series on managing ischemic stroke, Dr. Andrew Southerland talks with Dr. Dan Ackerman. Dr. Gregg Day talks with Dr. Brian Appleby about his paper discussing diagnostic testing for prion disease. 

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

In the 1st of a 5-part series on managing ischemic stroke, Dr. Andrew Southerland talks with Dr. Dan Ackerman. Dr. Stacey Clardy talks with Dr. Elizabeth Coon about her paper discussing phenoconversion in pure autonomic failure. 

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

In the first segment, the interviewer talks with Dr. Terence O'Brien about his paper on mortality in patients with non-epileptic seizures. Next, Dr. Jeffrey Ratliff talks with Dr. Nico Dosenbach about plasticity of functionally connected motor networks. Read Dr. Dosenbach's paper in Neuron: https://www.sciencedirect.com/science/article/abs/pii/S0896627320303536?via%3Dihub. 

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

In the first segment, Dr. Andrew Southerland speaks with Dr. J.G. Makin about his Nature article on thought-to-text technology. Then, Dr. Jason Crowell talks with Dr. Jonathan Kimmelman about his paper on expert crowd prediction on clinical trial response. Dr. Makin's article is available online at: https://www.nature.com/articles/s41593-020-0608-8.

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

In the first segment, Dr. Kathryn Nevel and Dr. Jennie Taylor discuss neuro-oncology. Next, Dr. Jeffrey Ratliff talks with Dr. David Charles about his paper discussing deep brain stimulation in early Parkinson disease.

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

In the first part of the podcast, Dr. Jeffrey Ratliff and Dr. Jason Crowell continue their discussion on movement disorder emergencies in the 2nd part of a 2-part dialogue. In the second segment, Dr. Stacey Clardy talks with Dr. Holly Hinson about her Neurology: Clinical Practice editorial on patient and public involvement in clinical trials from the June 2020 issue.

Disclosures can be found at Neurology.org.

No CME this week: Interviews based on articles from Neurology: Clinical Practice®, Neurology® Genetics, and Neurology® Neuroimmunology & Neuroinflammation are excluded from the CME program.

In the first segment, you’ll hear the first part of a 2-part conversation between Dr. Jeffrey Ratliff and Dr. Jason Crowell on movement disorder emergencies. In the second segment, Dr. Stacey Clardy talks with Dr. John Chen about his Neurology paper discussing maintenance therapy for MOG-IgG disorder. 

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

In the first segment, Dr. Jason Crowell talks with Dr. Daniel Claassen about his Neurology: Genetics paper on genotyping single nucleotide polymorphisms for allele-selective therapy in Huntington disease. In the second part of the podcast, Dr. Jeffrey Ratliff focuses his discussion with Dr. Roseanne Dobkin on telephone-based CBT for depression in patients with Parkinson disease.

Disclosures can be found at Neurology.org.

No CME this week: Interviews based on articles from Neurology: Clinical Practice®, Neurology® Genetics, and Neurology® Neuroimmunology & Neuroinflammation are excluded from the CME program.

In the 2nd part of this 2-part series, Dr. Halley Alexander interviews Dr. Michael Sperling about management of status epilepticus. 

Disclosures can be found at Neurology.org.

In the 1st part of this 2-part series, Dr. Halley Alexander interviews Dr. Michael Sperling about management of status epilepticus. 

Disclosures can be found at Neurology.org.

1. Distinguishing neurosarcoidosis from multiple sclerosis based on cerebrospinal fluid analysis: A retrospective study
2. What’s Trending: Personalized iPSC-Derived Dopamine Progenitor Cells for Parkinson’s Disease

In the first segment, the interviewer talks with Dr. Tarunya Arun about her paper discussing diagnosis of neurosarcoidosis. In the second part of the podcast, Dr. Jeffrey Ratliff talks with Dr. Jeffrey Schweitzer about his NEJM paper discussing progenitor cells for Parkinson disease. Read the NEJM article here: https://bit.ly/2XjHvuc.

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. Migraine and the under- and uninsured, pt. 2
2. NFL as a biomarker after mild TBI

In the first segment, you'll hear the second part of an interview on migraine between Dr. Jason Crowell and Dr. David Watson, focusing on special patient populations in management of migraine. In the second segment, the interviewer talks with Dr. Kimbra Kenney and Dr. Jessica Gill about their paper on NFL as a biomarker following traumatic brain injury. 

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. Migraine and the under- and uninsured, pt. 1
2. How to improve using Quality Outcomes Measurement Sets

In the first segment, Dr. Jason Crowell talks with Dr. David Watson about managing migraine in the first part of a two-part series. In the second segment, Dr. Jeff Ratliff talks with Dr. Jason Jonathan Sico about his Neurology paper on improving quality outcomes measurement sets. Part of the information in the discussion with Dr. Watson can be found in this paper in Current Pain and Headache Reports: https://link.springer.com/article/10.1007/s11916-019-0749-1. 

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. Daridorexant, a new dual orexin receptor antagonist, in elderly subjects with insomnia disorder
2. Living with Huntington’s, pt. 2

In the first segment, Dr. Jeffrey Ratliff talks with Dr. Yves Dauvilliers about their paper on insomnia treatment in the elderly. In the second part of the podcast, Dr. Jason Crowell continues his talk with Dr. Nancy Wexler about living with Huntington's disease.

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. Living with Huntington's Disease, pt. 1
2. Latest on PFO and stroke

In the first segment, you'll hear the first part of an interview between Dr. Jason Crowell and Dr. Nancy Wexler on living with Huntington's disease. In the second segment, Dr. Andrew Southerland talks with Dr. Steven Messe on his practice advisory update summary paper on patent foramen ovale and secondary stroke prevention. 

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. Treatment of Adult ADHD
2. Surrogates' Decisions after Acute Brain Injury

In the first segment, Dr. Teshamae Monteith talks with Dr. Scott Hirsch about treatment of adult ADHD. In the second segment, the interviewer talks with Dr. David Hwang about his Neurology paper on factors impacting surrogate decision makers for acute brain injury patients. 

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

Dr. Jason Crowell talks with Dr. Renee Shellhaas on courage during COVID-19 and on demonstrating leadership as neurologists in these circumstances. Read Dr. Shellhaas' special editorial: https://n.neurology.org/content/early/2020/04/24/WNL.0000000000009496. For a clearing house of neurology related information on the coronavirus go to https://www.aan.com/tools-and-resources/covid-19-neurology-resource-center/ to stay up-to-date.

1. What’s Trending: Epilepsy in the elderly
2. Scrambler therapy improves pain in neuromyelitis optica: A randomized controlled trial

In the first segment, Dr. Jeff Ratliff speaks with Dr. Scott Mintzer about epilepsy in the elderly. In the second segment, Dr. Jeff Ratliff talks with Dr. Maureen Mealy about her paper on the use of scrambler therapy for pain in neuromyelitis optica. 

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

The interviewer talks with Dr. Thomas Oxley about stroke as a presenting feature of COVID-19 in the young. Read Dr. Oxley's special correspondence in NEJM: https://www.nejm.org/doi/full/10.1056/NEJMc2009787. For a clearing house of neurology related information on the coronavirus go to https://www.aan.com/tools-and-resources/covid-19-neurology-resource-center/ to stay up-to-date.

1. What’s Trending: Joining Forces against Delirium — From Organ-System Care to Whole-Human Care
2. White matter hyperintensities mediate the association of nocturnal blood pressure with cognition

In the first segment, Dr. Greg Day speaks with Dr. Sharon Inouye about her NEJM article providing an update on delirium. The article is available online at: https://bit.ly/2UCh2Xo. In the second segment, Dr. Adam Brickman talks with Dr. Dan Ackerman about his Neurology paper on nocturnal blood pressure and cognition. 

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

Dr. Jason Crowell talks with Dr. Neil Busis and Dr. Brad Klein about teleneurology, tips for billing, and exams during the COVID-19 pandemic. Read the special editorial by Drs. Busis and Klein: https://n.neurology.org/content/early/2020/04/24/WNL.0000000000009494. For a clearing house of neurology related information on the coronavirus go to AAN.com/COVID19 to stay up-to-date.

Dr. Stacey Clardy talks with Dr. Ken Tyler about misinformation about SARS-CoV2 & gives updates on antibody testing and ongoing clinical trials. For a clearing house of neurology related information on the coronavirus go to AAN.com/COVID19 to stay up-to-date.

1. Prognostic value of diffusion-weighted MRI for post-cardiac arrest coma
2. PROMISE-2: Efficacy and safety of eptinezumab in patients with chronic migraine (Neurology®, March 31)

In the first segment, Dr. Rae Bacharach talks with Dr. Karen Hirsch about her paper on the prognostic value of diffusion-weighted MRI for post-cardiac arrest coma. In the second part of the podcast, Dr. Teshamae Monteith speaks with Dr. Richard Lipton about his Neurology® paper on eptinezumab for migraine, from the March 31^st issue.

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

Dr. Jeff Ratliff talks with Dr. Anna Bersano about being a neurologist in Italy during the COVID-19 pandemic. Read Dr. Bersano's special editorial in Neurology: https://n.neurology.org/content/early/2020/04/01/WNL.0000000000009508. For a clearing house of neurology related information on the coronavirus go to AAN.com/COVID19 to stay up-to-date.

The interviewer talks with Dr. Scott Kim about ethics in the time of COVID-19. Read Dr. Kim's editorial in Neurology: https://n.neurology.org/content/early/2020/04/06/WNL.0000000000009520. For a clearing house of neurology related information on the coronavirus go to AAN.com/COVID19 to stay up-to-date.

1. Neurology on the HIll
2. ALS is a multi-step process in South Korean, Japanese, and Australian patients (Neurology®: April 14)

In the first segment, Dr. Jason Crowell speaks with Dr. Andrew Southerland about Neurology on the Hill. In the second part of the podcast, Dr. Matthew Harms talks with Dr. Steve Vucic about his paper on multiple hit theory of ALS.

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

Dr. Teshamae Monteith talks with Dr. Joseph Kvedar about value-based care, e-consults, and telemedicine. For a clearing house of neurology related information on the coronavirus go to AAN.com/COVID19 to stay up-to-date.

Dr. Teshamae Monteith talks with Dr. Melissa Ko about telemedicine for neurologists caring for patients in light of COVID-19. For a clearing house of neurology related information on the coronavirus go to AAN.com/COVID19 to stay up-to-date.

1. Why Deep Brain Stimulation Works for Some People and Not Others (Neurology Today)
2. [What’s Trending]: Disease modification and biomarker development in Parkinson disease: Revision or reconstruction? (Neurology®: March 17)

In the first segment, Dr. Jeff Ratliff talks with Dr. Nico Dosenbach about his Neuron paper on neural networks and deep brain stimulation, and they specifically cover the Neurology Today article on this paper with respect to the impact on DBS. In the second part of the podcast, Dr. Jeff Ratliff speaks with Dr. Alberto Espay about his paper—from the March 17^th issue of Neurology—on reconsidering biomarkers in Parkinson disease. You can read the Neurology Today story here: https://bit.ly/2TzJr0Y; and you can read the Neuron paper here: https://bit.ly/2TX1zku.

Disclosures can be found at Neurology.org.

No CME this week: Interviews based on articles from Neurology: Clinical Practice®, Neurology® Genetics, and Neurology® Neuroimmunology & Neuroinflammation, or from articles from issues for which a CME exam has previously been issued, are excluded from the CME program.

Dr. Ian Lipkin discusses his own diagnosis with COVID-19 and what neurologists can do in light of the pandemic to keep safe and to serve patients. For a clearing house of neurology related information on the coronavirus go to AAN.com/COVID19 to stay up-to-date.

Find the cast of Contagion's PSAs on the pandemic: https://abcnews.go.com/Entertainment/cast-contagion-issues-psa-coronavirus-pandemic/story?id=69853838. 

Find Columbia University's Control the Contagion page: https://www.publichealth.columbia.edu/controlthecontagion. 

This month’s Delayed Recall highlights 13 interviews on functional neurologic disorders from the series conducted with Jon Stone for the Neurology Minute podcast. The episodes aired between September 2019 and March 2020. In this series, Jon Stone discusses who is susceptible to FNDs, diagnosis of nonepileptic spells, the myth of FND as psychological disorders with psychological origins, the various treatments available to patients with functional neurologic disorders, and other topics.

1. Effect of generic glatiramer acetate on spending and use of drugs for multiple sclerosis
2. [What’s Trending]: Association between out-of-pocket costs and adherence to common neurologic medications

In the first segment, Dr. Jason Crowell speaks with Dr. Brian Callaghan about his paperon the association between out-of-pocket costs and adherence to common neurologic medications. In the second part of the podcast, Dr. Jason Crowell talks with Dr. Daniel Hartung about his paper—also from the March 31st issue of Neurology—on the effect of generic glatiramer acetate on the reduction of MS costs. 

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. New evidence on the management of Lewy body dementia
2. [What’s Trending]: Pathologic tearfulness after limbic encephalitis: A novel disorder and its neural basis

In the first segment, Dr. Matthew Barrett talks with Dr. John-Paul Taylor about his paper on Lewy body dementia management, from The Lancet. In the second part of the podcast, Dr. Stacey Clardy speaks with Dr. Chris Butler about his paper on pathologic tearfulness after limbic encephalitis. You can read Dr. Taylor’s paper in The Lancet here: https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(19)30153-X/fulltext.

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. Preserving the patient-physician relationship, with Dr. John Noseworthy
2. [What’s Trending]: Blood NFl and MS treatment

In the first segment, Dr. Jason Crowell speaks with Dr. John Noseworthy on his NEJM article on preserving the physician-patient relationship, which you can read here: https://www.nejm.org/doi/full/10.1056/NEJMsr1912662. In the second part of the podcast, the interviewer talks with Dr. Frederik Piehl about his Neurology paper discussing how blood neurofilament-light levels segregate treatment effects in patients with multiple sclerosis. 

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. Antiepileptic drugs are not independently associated with cognitive dysfunction
2. [What’s Trending]: Pan-viral serology implicates enteroviruses in acute flaccid myelitis

In the first segment, Dr. Halley Alexander talks with Dr. Emma Foster about her paper on her paper discussing that antiepileptic drugs are not independently associated with cognitive dysfunction. In the second part of the podcast, the interviewer speaks with Dr. Michael Wilson and Dr. Ryan Schubert on their article in Nature Medicine, “Pan-viral serology implicates enteroviruses in acute flaccid myelitis,” which you can read here: https://www.nature.com/articles/s41591-019-0613-1.

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. Minimal breastmilk transfer of rituximab, a monoclonal antibody used in neurological conditions (Neurology®: Neuroimmunology & Neuroinflammation)
2. [What’s Trending]: Obscure Model Puts a Price on Good Health—and Drives Down Drug Costs

In the first segment, the interviewer talks with Dr. Riley Bove about her paper on minimal breastmilk transfer of rituximab, a monoclonal antibody used in neurological conditions. In the second part of the podcast, Dr. Jason Crowell speaks with Denise Roland of the Wall Street Journal about her story on an obscure model driving down drug costs. You can read the article in the Wall Street Journal here: https://www.wsj.com/articles/obscure-model-puts-a-price-on-good-healthand-drives-down-drug-costs-11572885123.

Disclosures can be found at Neurology.org.

No CME this week: Interviews based on articles from Neurology® Clinical Practice, Neurology® Genetics, and Neurology® Neuroimmunology & Neuroinflammation are excluded from the CME program.

1. Randomized trial of three anticonvulsant medications for status epilepticus
2. [What’s Trending]: Review of the future of neuroimmunology & neuroinflammation

In the first segment, Dr. Stacey Clardy talks with Dr. Robert Silbergleit and Dr. Jaideep Kapur about anticonvulsant medications for status epilepticus. In the second part of the podcast, the interviewer talks with Dr. Josep Dalmau and Dr. Francesc Graus about about the future of neuroimmunology and neuroinflammation.  You can read Dr. Silbergleit and Dr. Kapur's paper in the New England Journal of Medicine here: https://www.nejm.org/doi/full/10.1056/NEJMoa1905795.

Disclosures can be found at Neurology.org.

No CME this week: Interviews based on articles from Neurology® Clinical Practice, Neurology® Genetics, and Neurology® Neuroimmunology & Neuroinflammation are excluded from the CME program.

1. Clinical features of seronegative, but CSF antibody positive, anti-NMDA receptor encephalitism (Neurology: Neuroimmunology & Neuroinflammation)
2. [What’s Trending]: the year in infectious encephalitis and arthropod-borne infections

In the first segment, the interviewer talks with Dr. Josep Dalmau and Dr. Francesc Graus about their Neurology: Neuroimmunology & Neuroinflammation paper on clinical features of seronegative, but CSF antibody positive, anti-NMDA receptor encephalitis. In the second part of the podcast, Dr. Stacey Clardy talks with Dr. Ken Tyler about infectious encephalitis and arthropod-borne infections in 2019.

Disclosures can be found at Neurology.org.

No CME this week: Interviews based on articles from Neurology® Clinical Practice, Neurology® Genetics, and Neurology® Neuroimmunology & Neuroinflammation are excluded from the CME program.

1. Visual snow syndrome: A clinical and phenotypical description of 1,100 patients
2. [What’s Trending]: Patient charity settles allegations it helped MS drug makers pay kickbacks

In the first segment, Dr. Teshamae Monteith talks with Dr. Francesca Puledda about her paper providing a clinical and phenotypical description of visual snow syndrome. In the second part of the podcast, Dr. Jason Crowell talks with Ed Silverman about the settlement over allegations that a patient charity helped MS drug makers pay kickbacks. You can read Mr. Silverman’s story in STAT: https://www.statnews.com/2019/11/20/patient-charity-allegations-ms-drug-makers-kickbacks/.

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. Quality improvement in dementia care: Dementia Management Quality Measurement Set 2018 implementation update
2. [What’s Trending]: Patient-Customized Oligonucleotide Therapy for a Rare Genetic Disease

In the first segment, Dr. Jason Crowell talks with Dr. Timothy Yu about patient-customized oligonucleotide therapy for a rare genetic disease. In the second part of the podcast, Dr. Jeffrey Burns talks with Dr. Amy Sanders about her implementation update on quality improvement in dementia care. You can read Dr. Yu’s paper in the NEJM: https://www.nejm.org/doi/full/10.1056/NEJMoa1813279.

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. A qualitative study on the price of drugs for multiple sclerosis: “Gaming the system”
2. [What’s Trending]: Duration of American football play and chronic traumatic encephalopathy

In the first segment, Dr. Jason Crowell talks with Dr. Daniel Hartung about his qualitative study on drug prices for MS. In the second part of the podcast, the interviewer talks with Dr. Jesse Mez about the duration of American football play and chronic traumatic encephalopathy. You can read Dr. Mez’s paper in the Annals of Neurology: https://onlinelibrary.wiley.com/doi/10.1002/ana.25611.

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. Longitudinal change in regional brain volumes with exposure to repetitive head impacts
2. [What’s Trending]: Infant colic and episodic syndromes

In the first segment, Dr. Jeffrey Ratliff talks with Dr. Charles Bernick about his paper on longitudinal change in regional brain volumes with exposure to repetitive head impacts. In the second part of the podcast, Dr. Teshamae Monteith talks with Dr. Amy Gelfand about infant colic and episodic syndromes.

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. Hashimoto encephalopathy in the 21st century
2. [What’s Trending]: Migraine Progression in Subgroups of Migraine Based on Comorbidities: Results of the CaMEO Study

In the first segment, Dr. Stacey Clardy talks with Dr. Francesc Graus and Dr. Josep Dalmau about their paper on Hashimoto encephalopathy in the 21st century. In the second part of the podcast, Dr. Teshamae Monteith talks with Dr. Richard Lipton and Dr. Dawn Buse about migraine progression in subgroups of migraine based on comorbidities.

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. Targeted, next-generation, sequencing panels in the diagnosis of Charcot-Marie-Tooth disease
2. [What’s Trending]: Gut Microbe to Brain Signaling: What Happens in Vagus…

In the first segment, Dr. Michelle Mauermann talks with Dr. Mary Reilly about her paper on targeted, next-generation, sequencing panels in the diagnosis of Charcot-Marie-Tooth disease. In the second part of the podcast, the interviewer talks with Dr. Christine Fulling about gut microbiota and brain signaling via the vagus nerve to affect brain and behavior.

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

This week, Dr. Ted Burns, creator and former editor of the Neurology Podcast, discusses the history, process, and meaning of the podcast.

This week, we feature past interviews with Dr. Mike Wilson on metagenomics.

Dr. Stacey Clardy talks with Nobel Laureate Peter Doherty about his collaborative work with Rolf Zinkernagel regarding how the body's immune system distinguishes virus-infected cells from normal cells, among many other topics.

1. Three-year follow-up of prospective trial of focused ultrasound thalamotomy for essential tremor
2. Statins for Neuroprotection in Spontaneous Intracerebral Hemorrhage

In the first segment, Dr. Jason Crowell talks with Dr. Casey Halpern about his paper on a three-year follow-up of a prospective trial of focused ultrasound thalamotomy for essential tremor. In the second part of the podcast, Dr. Will Rondeau talks with Dr. Jared Chen and Dr. Andrew Southerland about statins for neuroprotection in spontaneous intracerebral hemorrhage.

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. Treatment and prevention of neuromyelitis optica
2. Physical activity and prodromal features of Parkinson's disease

In the first segment, Dr. Ted Burns talks with Dr. Stacey Clardy about neuromyelitis optica. In the second part of the podcast, Dr. Jason Crowell talks with Dr. Alberto Ascherio about his paper on physical activity and prodromal features of Parkinson disease. 

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories
2. [What’s Trending]: gnostic indicators of improvement with therapeutic plasma exchange in pediatric demyelination

In the first segment, the interviewer talks with Dr. Thomas Kilduff about his Science report article reporting that REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories, which you can read here: https://science.sciencemag.org/content/365/6459/1308. In the second segment, Dr. Stacey Clardy talks with Dr. Sylvia Tenembaum about her paper on prognostic indicators of improvement with therapeutic plasma exchange in pediatric demyelination. 

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. Neurosyphilis
2. [What’s Trending]: Symptom burden among individuals with Parkinson disease: A national survey (Neurology: Clinical Practice)

In the opening segment, the interviewer talks with Dr. Allan Ropper about his NEJM paper on neurosyphilis, which you can read here: https://www.nejm.org/doi/full/10.1056/NEJMx190030. In the second part, Dr. Jeffrey Ratliff talks with Dr. Christopher Tarolli about his Neurology: Clinical Practice paper on symptom burden among individuals with Parkinson disease. 

Disclosures can be found at Neurology.org.

No CME this week: Interviews based on articles from Neurology® Clinical Practice, Neurology® Genetics, and Neurology® Neuroimmunology & Neuroinflammation are excluded from the CME program.

1. Editorial: Social Health and Brain Health: Does neurology also have a duty to treat social ills?
2. [What’s Trending]: Practice guideline update summary: Pharmacologic treatment for pediatric migraine prevention

In the first segment, Dr. Jason Crowell talks with Dr. Joel Salinas about his editorial on neurologists’ duty to treat social ills. In the second part of the podcast, Dr. Teshamae Monteith talks with Dr. Andrew Hershey about his practice guideline update summary paper in Neurology® on pharmacologic treatment for pediatric migraine prevention. You can read "Practice Guideline Update: Pharmacologic Treatment for Pediatric Migraine Prevention" here: https://www.aan.com/Guidelines/home/GuidelineDetail/967. For further reading, there is also "Practice Guideline Update: Acute Treatment of Migraine in Children and Adolescents" here: https://www.aan.com/Guidelines/home/GuidelineDetail/966. 

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. More prominent muscle involvement in dermatomyositis patients with anti-Mi2 autoantibodies
2. [What’s Trending]: Lawrence Weschler discusses Oliver Sacks, pt. 2

In the first segment, Dr. Stacey Clardy continues her talk with Lawrence Weschler about his book on Oliver Sacks, And How are You, Dr. Sacks?, in the second of a two-part interview.  In the second part of the podcast, Dr. Stacey Clardy talks with Dr. Andrew Mammen about his paper on more prominent muscle involvement in dermatomyositis patients with anti-Mi2 autoantibodies.

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. Autologous, nonmyeloablative hematopoietic stem-cell transplantation for neuromyelitis optica
2. [What’s Trending]: Lawrence Weschler discusses Oliver Sacks, pt. 1

In the first segment, Dr. Stacey Clardy talks with Dr. Richard Burt about his paper on autologous, nonmyeloablative hematopoietic stem-cell transplantation for neuromyelitis optica. In the second part of the podcast, Dr. Stacey Clardy speaks with Dr. Lawrence Weschler about his book on Oliver Sacks, And How are You, Dr. Sacks?, in the first of a two-part interview.

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. Testing Blood for Amyloid Beta-42 to Predict Future Brain Amyloidosis
2. [What’s Trending]: Nobel Laureate Stanley Prusiner about his impact on neurology, pt. 2

In the first segment, Dr. Jeff Burns talks with Dr. Randall Bateman about his paper addressing how high precision plasma amyloid-β 42/40 predicts current and future brain amyloidosis. In the second part of the podcast, you'll hear the second part of an interview with Nobel Prize winner Dr. Stanley H. Prusiner. 

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. Orthostatic hypotension in Parkinson disease: A 7-year prospective population-based study
2. [What’s Trending]: Nobel Laureate Stanley Prusiner about his impact on neurology, pt. 1

In the first segment, Dr. Jeffrey Ratliff talks with Dr. Ylva Hiorth and about their paper on a 7-year prospective population-based study on orthostatic hypotension in Parkinson disease. In the second part of the podcast, Dr. Jason Crowell talks with Nobel Prize winner Dr. Stanley B. Prusiner in the first of a two-part interview.

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1.The World Health Organization's essential diagnostics list: Diagnostics for neurologic disorders
2. [What's Trending]: Eculizumab in Aquaporin-4–Positive Neuromyelitis Optica Spectrum Disorder

In the first segment, Dr. Greg Day talks with Dr. Kiran Thakur and Dr. Greer Waldrop about their paper on diagnostics for neurologic disorders on the World Health Organization’s essential diagnostic list. In the second part of the podcast, Dr. Stacey Clardy speaks with Dr. Sean Pittock on his NEJM paper on eculizumab in aquaporin-4–positive neuromyelitis optica spectrum disorder.

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. Combination therapy with nusinersen and AVXS-101 in SMA type 1
2. [What's Trending]: Neuroimaging Findings in US Government Personnel With Possible Exposure to Directional Phenomena in Havana, Cuba

In the first segment, Dr. Jason Crowell talks with Dr. Emma Ciafaloni about her clinical/scientific note on combination therapy with nusinersen and AVXS-101 in SMA type 1. In the second part of the podcast, Dr. Jason Crowell speaks with Dr. Douglas Smith on neuroimaging findings in US government personnel with possible exposure to directional phenomena in Havana, Cuba.

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1.Practice guideline update summary: Vaccine-preventable infections and immunization in multiple sclerosis
2. [What's Trending]: Drug pricing update, part 2

In the first segment, Dr. Stacey Clardy talks with Dr. Mauricio Farez about his practice guideline update summary on vaccine-preventable infections and immunization in multiple sclerosis. In the second part of the podcast, Dr. Gordon Smith continues his discussion with Dr. Steve Pearson on an update on drug pricing. Their previous discussion on drug pricing was featured in two parts on January 8^th and January 15^th, 2019.

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1.Understanding and addressing gender equity for women in neurology
2. [What’s Trending]: Drug pricing update, part 1

In the first segment, Dr. Stacey Clardy talks with Dr. Julie Silver about her paper on understanding and addressing gender equity for women in neurology. In the second part of the podcast, Dr. Gordon Smith focuses his discussion with Dr. Steve Pearson on an update on drug pricing. Their previous discussion on drug pricing was featured in two parts on January 8^th and January 15^th, 2019.

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. Varied Phenotypes and Management of Immune Checkpoint Inhibitor Associated Neuropathies
2. [What's Trending]: Clinical Metagenomic Sequencing for Diagnosis of Meningitis and Encephalitis

In the first segment, Dr. Noah Kolb talks with Dr. Amanda Guidon about her paper on varied phenotypes and management of immune checkpoint inhibitor associated neuropathies. In the second part of the podcast, Dr. Stacey Clardy focuses her discussion with Dr. Mike R. Wilson on clinical metagenomic sequencing for diagnosis of meningitis and encephalitis. Read the full NEJM article here: https://www.nejm.org/doi/full/10.1056/NEJMoa1803396.

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. Therapy for acute nerve agent poisoning: An update (Neurology®: Clinical Practice)
2. [What's Trending]: Detection of Brain Activation in Unresponsive Patients with Acute Brain Injury

In the first segment, Dr. Alex Menze talks with Dr. Jonathan Newmark about his Neurology: Clinical Practice paper that provides an update on therapy for acute nerve agent poisoning. In the second part of the podcast, Dr. Andrew Schomer focuses his discussion with Dr. Jan Claassen on detection of brain activation in unresponsive patients with acute brain injury. Read the full NEJM article here: https://www.nejm.org/doi/full/10.1056/NEJMoa1812757.  

Disclosures can be found at Neurology.org.

No CME this week: Interviews based on articles from Neurology® Clinical Practice, Neurology® Genetics, and Neurology® Neuroimmunology & Neuroinflammation are excluded from the CME program.

1. A large case-control study on vaccination as risk factor of multiple sclerosis
2. [What's Trending]: Zika update 2019

In the first segment, the interviewer talks with Dr. Bernard Hemmer about his paper on a large case-control study on vaccination as risk factor of multiple sclerosis. In the second part of the podcast, Dr. Stacey Clardy focuses her discussion with Dr. Amanda Grennell on an update on Zika for 2019. Read the full article here: https://www.nature.com/articles/d41586-019-01906-z.  

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. Phosphodiesterase 10A-IgG: A novel biomarker of paraneoplastic neurological autoimmunity
2. [What’s Trending]: "Evergreening" and drug prices

In the first segment, Dr. Stacey Clardy talks with Dr. Anastasia Zekeridou about her paper on Phosphodiesterase 10A-IgG, a novel biomarker of paraneoplastic neurological autoimmunity. In the second part of the podcast, Dr. Jason Crowell focuses his discussion with Prof. Robin Feldman on “evergreening” and drug prices. Read the full article here: https://www.nature.com/articles/d41586-019-01906-z.   

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. Impulse control disorders in Parkinson disease and RBD: A longitudinal study of severity
2. [What’s Trending]: CRISPR babies: when will the world be ready?

In the first segment, Dr. Jason Crowell talks with Dr. Michele Hu and Dr. David Okai about their longitudinal study of the severity of impulse control disorders in Parkinson disease and RBD. In the second part of the podcast, Dr. Jason Crowell focuses his discussion with Dr. Heidi Ledford on her Nature article discussing CRISPR babies and what would be required to make gene editing safe and acceptable. Read the full article here: https://www.nature.com/articles/d41586-019-01906-z.   

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. Cumulative gadodiamide administration leads to brain gadolinium deposition in early MS
2. [What's Trending]: Network localization of cervical dystonia based on causal brain lesions

In the first segment, Dr. Stacey Clardy talks with Dr. Robert Zivadinov about cumulative gadodiamide administration leading to brain gadolinium deposition in early MS. In the second part of the podcast, Dr. Jeffrey Ratliff focuses his discussion with Dr. Michael D. Fox on his Brain paper on network localization of cervical dystonia based on causal brain lesions. You can read the paper here: https://academic.oup.com/brain/article-abstract/142/6/1660/5491101?redirectedFrom=fulltext.  

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. CDC’s Guideline on Pediatric Mild Traumatic Brain Injury: Recommendations for Neurologists (Neurology: Clinical Practice)
2. [What's Trending]: Thrombolysis Guided by Perfusion Imaging up to 9 Hours after Onset of Stroke

In the first segment, Dr. Kristen Heinan talks with Dr. Barbara Weissman about her Neurology: Clinical Practice paper on recommendations for neurologists on the CDC’s Guideline on Pediatric Mild Traumatic Brain Injury. In the second part of the podcast, Dr. Will Rondeau focuses his discussion with Dr. Geoffrey Donnan on his NEJM paper on thrombolysis guided by perfusion Imaging up to 9 hours after onset of stroke. You can read the paper here: https://www.nejm.org/doi/pdf/10.1056/NEJMoa1813046.

Disclosures can be found at Neurology.org.

1. Determining clinically meaningful decline in preclinical Alzheimer disease
2. [What's Trending]: Targeting Huntington expression in patients with Huntington's disease

In the first segment, Dr. Gregory Day talks with Dr. Philip Insel about his paper on determining clinically meaningful decline in preclinical Alzheimer disease. In the second part of the podcast, Dr. Sarah Tabrizi talks about targeting Huntington expression in patients with Huntington's disease in her interview with Dr. Jeffrey Ratliff. Read Dr. Tabrizi's paper in NEJM: https://www.nejm.org/doi/full/10.1056/NEJMoa1900907?query=recirc_curatedRelated_article. 

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. SUDEP in the North American SUDEP Registry: The full spectrum of epilepsies
2. [What's Trending]: Long-term effect of thymectomy plus prednisone versus prednisone alone in patients with non-thymomatous myasthenia gravis: 2-year extension of the MGTX randomised trial

In the first segment, Dr. Halley Alexander talks with Dr. Orrin Devinsky about his paper on the full spectrum of epilepsies and the North American SUDEP Registry. In the second part of the podcast, Dr. Ted Burns focuses his discussion with Dr. Gil Wolfe on his Lancet Neurology paper on the long-term effect of thymectomy plus prednisone versus prednisone alone in patients with non-thymomatous myasthenia gravis. You can read the paper here: https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(18)30392-2/fulltext.  

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. Use of ß2-adrenoreceptor agonist and antagonist drugs and risk of Parkinson disease
2. [What's Trending]: The US Food and Drug Administration’s Authorization of the First Cannabis-Derived Pharmaceutical

In the first segment, Dr. Jeffrey Ratliff talks with Dr. Franziska Hopfner about her paper on the use of ß2-adrenoreceptor agonist and antagonist drugs and risk of Parkinson disease. In the second part of the podcast, Dr. Jason Crowell focuses his discussion with Dr. Jerzy Szaflarski on his JAMA Neurology paper on the US Food and Drug Administration’s authorization of the first cannabis-derived pharmaceutical. You can read the paper here: https://jamanetwork.com/journals/jamaneurology/article-abstract/2714720.

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. Current treatment practice of Guillain-Barré syndrome
2. [What's Trending]: Somatic expansion of the C9orf72 Hexanucleotide Repeat does not occur in ALS spinal cord tissues (Neurology: Genetics)

In the first segment, Dr. Michelle Mauermann talks with Dr. Bart Jacobs about his paper on current treatment practice of Guillain-Barré syndrome. In the second part of the podcast, Dr. Matthew Harms focuses his discussion with Dr. Guy Rouleau on his Neurology: Genetics paper looking at how somatic expansion of the C9orf72 Hexanucleotide Repeat does not occur in ALS spinal cord tissues.

1. Interview with Neurology Editor-in-Chief Bob Gross, pt. 2

In the second part of a 2-part interview, Dr. Bob Gross changes to the journal and publishing as well as some controversies and challenges as Editor-in-Chief of Neurology.

1. Interview with Neurology Editor-in-Chief Bob Gross, pt. 1

In the first part of a 2-part interview, Dr. Bob Gross discusses his experiences, opportunities, and challenges as Editor-in-Chief of Neurology.

1. Lumbosacral Radiculoplexus Neuropathy: Incidence and the Association with Diabetes Mellitus

2. [What’s Trending]: CRGP monoclonal antibodies for migraine prevention

In the first segment, Dr. Stacey Clardy talks with Dr. P. James B. Dyck about his paper on the incidence of lumbrosacral radiculoplexus neuropathy and association with diabetes mellitus, from the March 12th issue. In the second segment, the interviewer talks with Dr. Teshamae Monteith about the use of CRGP monoclonal antibodies for migraine prevention. 

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. The Four Score as a predictor of outcome in adults with bacterial meningitis

2. [What’s Trending]:Opioid prescribing and response to the CDC guidelines

In the first segment, the interviewer talks with Dr. C.N. van Ettekoven about the Four Score as a predictor of outcome in adults with bacterial meningitis, from the May 28th issue. In the second part of the podcast, Dr. Jason Crowell focuses his talk with Dr. Deborah Dowell on her NEJM perspective article looking at opioid prescribing and response to the CDC guidelines. You can read Dr. Dowell’s paper here: https://www.nejm.org/doi/full/10.1056/NEJMp1904190.

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. Out-of-pocket Costs are on the Rise for Commonly Prescribed Neurologic Medications

2. [What’s Trending]: Diagnosing Genetic Ataxias

In the first segment, Dr. Jason Crowell talks with Dr. Brian Callaghan about the rising out-of-pocket costs for commonly prescribed neurologic medications. In the second part of the podcast, Dr. Jeffrey Ratliff focuses his interview with Dr. Stefan Pulst on diagnosing genetic ataxias.

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. Long-term outcome in neuroZika: When biological diagnosis matters

2. [What’s Trending]: Full Study Report of Andexanet Alfa for Bleeding Associated with Factor Xa Inhibitors (NEJM)

In the first segment, Dr. Stacey Clardy talks with Dr. Annie Lannuzel about the importance of biological diagnosis in long-term outcome in neuroZika. In the second part of the podcast, Dr. Will Rondeau focuses his interview with Dr. Stuart Connolly on his NEJM paper on the full study report of andexanet alfa for bleeding associated with factor Xa inhibitors. The paper can be found here: https://www.nejm.org/doi/full/10.1056/NEJMoa1814051.

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. Meta-analysis and cost-effectiveness of second-line antiepileptic drugs for status epilepticus 

2. [What’s Trending]: Measles in 2019

In the first segment, Dr. Lindsay Higdon talks with Dr. Ivan Sanchez Fernandez about his paper on the meta-analysis and cost-effectiveness of second-line antiepileptic drugs for status epilepticus. In the second part of the podcast, Dr. Stacey Clardy talks with Dr. Anthony Fauci about the measles outbreak of 2019. You can read the paper in NEJM: https://www.nejm.org/doi/full/10.1056/NEJMp1905099. 

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. Practice guideline recommendations summary: The treatment of tics in people with Tourette syndrome and chronic tic disorders 

2. [What’s Trending]: CRISPR and gene editing, pt. 2

In the first segment, Dr. Jeffrey Ratliff talks with Dr. Tamara Milka Pringsheim about her practice guideline recommendations summary paper on the treatment of tics in people with Tourette syndrome and chronic tic disorders. In the What's Trending segment, you'll hear the second part of an interview between Dr. Jason Crowell and New York Times staff writer Pam Belluck on CRISPR and gene editing.

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. Neurology: Neuroimmunology & Neuroinflammation: Mouse model of anti-NMDA receptor post–herpes simplex encephalitis

2. [What's Trending]:Gene Editing

In the first segment, Dr. Stacey Clardy talks with Dr. Jenny Linnoila about her March 2019 Neurology: Neuroimmunology & Neuroinflammation paper on a mouse model of anti-NMDA receptor post–herpes simplex encephalitis. In the second part of the podcast, you will hear the first part of a 2-part interview about CRISPR and gene editing with New York Times staff writer Pam Belluck and Dr. Jason Crowell. You can read the NYT story here: https://www.nytimes.com/2019/04/14/health/gene-editing-babies.html?rref=collection%2Fbyline%2Fpam-belluck.

And, you will find the follow up here: https://www.nytimes.com/2019/04/16/health/stanford-gene-editing-babies.html?rref=collection%2Fbyline%2Fpam-belluck

Disclosures can be found at Neurology.org.

No CME this week: Interviews based on articles from Neurology® Clinical Practice, Neurology® Genetics, and Neurology® Neuroimmunology & Neuroinflammation are excluded from the CME program.

1. Neurology: Clinical Practice: Montreal Cognitive Assessment as a screening tool: Influence of performance and symptom validity 

2. [What’s Trending]:  Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease  

In the first segment, Dr. Gregory Day talks with Dr. Brigid Waldron-Perrine about her Neurology: Clinical Practice paper addressing the Montreal Cognitive Assessment as a screening tool. In the second part of the podcast, Dr. Jeffrey Burns focuses his interview with Dr. Mathias Jucker on how serum neurofilament dynamics predict neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease. The article can be found in Nature: https://www.nature.com/articles/s41591-018-0304-3.

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. Comparative effectiveness of teriflunomide and dimethyl fumarate. A nationwide cohort study

2. [What’s Trending]: The Rise of Pseudomedicine for Dementia and Brain Health

In the first segment, Dr. Stacey Clardy talks with Dr. Mathias Buron about his paper addressing the comparative effectiveness of teriflunomide and dimethyl fumarate. In the second part of the podcast, Dr. Jason Crowell focuses his interview with Dr. Joanna Hellmuth on the rise of pseudomedicine for dementia and brain health.

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. How much do periventricular lesions assist in distinguishing migraine with aura from CIS?

2. [What’s Trending]: Drug Pricing--Politico

In the first segment, Dr. Stacey Clardy talks with Dr. Caterina Lapucci about her paper addressing how much periventricular lesions assist in distinguishing migraine with aura from CIS. In the second part of the podcast, Dr. Jason Crowell focuses his interview with Sarah Karlin-Smith and Sarah Owermohle from Politico on drug pricing.

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. Automated seizure detection accuracy for ambulatory EEG recordings

2. [What’s Trending]: SHINE Stroke Trial

In the first segment, Dr. Derek Bauer talks with Dr. Stephan Schuele about his paper on automated seizure detection accuracy for ambulatory EEG recordings. In the second part of the podcast, Dr. Nicole Chiota-McCollum focuses her interview with Dr. Kevin Barrett on the SHINE stroke trial.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.