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1. Why Deep Brain Stimulation Works for Some People and Not Others (Neurology Today)
2. [What’s Trending]: Disease modification and biomarker development in Parkinson disease: Revision or reconstruction? (Neurology®: March 17)

In the first segment, Dr. Jeff Ratliff talks with Dr. Nico Dosenbach about his Neuron paper on neural networks and deep brain stimulation, and they specifically cover the Neurology Today article on this paper with respect to the impact on DBS. In the second part of the podcast, Dr. Jeff Ratliff speaks with Dr. Alberto Espay about his paper—from the March 17^th issue of Neurology—on reconsidering biomarkers in Parkinson disease. You can read the Neurology Today story here: https://bit.ly/2TzJr0Y; and you can read the Neuron paper here: https://bit.ly/2TX1zku.

Disclosures can be found at Neurology.org.

No CME this week: Interviews based on articles from Neurology: Clinical Practice®, Neurology® Genetics, and Neurology® Neuroimmunology & Neuroinflammation, or from articles from issues for which a CME exam has previously been issued, are excluded from the CME program.

1. Effect of generic glatiramer acetate on spending and use of drugs for multiple sclerosis
2. [What’s Trending]: Association between out-of-pocket costs and adherence to common neurologic medications

In the first segment, Dr. Jason Crowell speaks with Dr. Brian Callaghan about his paperon the association between out-of-pocket costs and adherence to common neurologic medications. In the second part of the podcast, Dr. Jason Crowell talks with Dr. Daniel Hartung about his paper—also from the March 31st issue of Neurology—on the effect of generic glatiramer acetate on the reduction of MS costs. 

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. New evidence on the management of Lewy body dementia
2. [What’s Trending]: Pathologic tearfulness after limbic encephalitis: A novel disorder and its neural basis

In the first segment, Dr. Matthew Barrett talks with Dr. John-Paul Taylor about his paper on Lewy body dementia management, from The Lancet. In the second part of the podcast, Dr. Stacey Clardy speaks with Dr. Chris Butler about his paper on pathologic tearfulness after limbic encephalitis. You can read Dr. Taylor’s paper in The Lancet here: https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(19)30153-X/fulltext.

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. Preserving the patient-physician relationship, with Dr. John Noseworthy
2. [What’s Trending]: Blood NFl and MS treatment

In the first segment, Dr. Jason Crowell speaks with Dr. John Noseworthy on his NEJM article on preserving the physician-patient relationship, which you can read here: https://www.nejm.org/doi/full/10.1056/NEJMsr1912662. In the second part of the podcast, Dr. David Lapides talks with Dr. Frederik Piehl about his Neurology paper discussing how blood neurofilament-light levels segregate treatment effects in patients with multiple sclerosis. 

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. Antiepileptic drugs are not independently associated with cognitive dysfunction
2. [What’s Trending]: Pan-viral serology implicates enteroviruses in acute flaccid myelitis

In the first segment, Dr. Halley Alexander talks with Dr. Emma Foster about her paper on her paper discussing that antiepileptic drugs are not independently associated with cognitive dysfunction. In the second part of the podcast, Dr. David Lapides speaks with Dr. Michael Wilson and Dr. Ryan Schubert on their article in Nature Medicine, “Pan-viral serology implicates enteroviruses in acute flaccid myelitis,” which you can read here: https://www.nature.com/articles/s41591-019-0613-1.

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. Minimal breastmilk transfer of rituximab, a monoclonal antibody used in neurological conditions (Neurology®: Neuroimmunology & Neuroinflammation)
2. [What’s Trending]: Obscure Model Puts a Price on Good Health—and Drives Down Drug Costs

In the first segment, Dr. David Lapides talks with Dr. Riley Bove about her paper on minimal breastmilk transfer of rituximab, a monoclonal antibody used in neurological conditions. In the second part of the podcast, Dr. Jason Crowell speaks with Denise Roland of the Wall Street Journal about her story on an obscure model driving down drug costs. You can read the article in the Wall Street Journal here: https://www.wsj.com/articles/obscure-model-puts-a-price-on-good-healthand-drives-down-drug-costs-11572885123.

Disclosures can be found at Neurology.org.

No CME this week: Interviews based on articles from Neurology® Clinical Practice, Neurology® Genetics, and Neurology® Neuroimmunology & Neuroinflammation are excluded from the CME program.

1. Randomized trial of three anticonvulsant medications for status epilepticus
2. [What’s Trending]: Review of the future of neuroimmunology & neuroinflammation

In the first segment, Dr. Stacey Clardy talks with Dr. Robert Silbergleit and Dr. Jaideep Kapur about anticonvulsant medications for status epilepticus. In the second part of the podcast, Dr. David Lapides talks with Dr. Josep Dalmau and Dr. Francesc Graus about about the future of neuroimmunology and neuroinflammation.  You can read Dr. Silbergleit and Dr. Kapur's paper in the New England Journal of Medicine here: https://www.nejm.org/doi/full/10.1056/NEJMoa1905795.

Disclosures can be found at Neurology.org.

No CME this week: Interviews based on articles from Neurology® Clinical Practice, Neurology® Genetics, and Neurology® Neuroimmunology & Neuroinflammation are excluded from the CME program.

1. Clinical features of seronegative, but CSF antibody positive, anti-NMDA receptor encephalitism (Neurology: Neuroimmunology & Neuroinflammation)
2. [What’s Trending]: the year in infectious encephalitis and arthropod-borne infections

In the first segment, Dr. David Lapides talks with Dr. Josep Dalmau and Dr. Francesc Graus about their Neurology: Neuroimmunology & Neuroinflammation paper on clinical features of seronegative, but CSF antibody positive, anti-NMDA receptor encephalitis. In the second part of the podcast, Dr. Stacey Clardy talks with Dr. Ken Tyler about infectious encephalitis and arthropod-borne infections in 2019.

Disclosures can be found at Neurology.org.

No CME this week: Interviews based on articles from Neurology® Clinical Practice, Neurology® Genetics, and Neurology® Neuroimmunology & Neuroinflammation are excluded from the CME program.

1. Visual snow syndrome: A clinical and phenotypical description of 1,100 patients
2. [What’s Trending]: Patient charity settles allegations it helped MS drug makers pay kickbacks

In the first segment, Dr. Teshamae Monteith talks with Dr. Francesca Puledda about her paper providing a clinical and phenotypical description of visual snow syndrome. In the second part of the podcast, Dr. Jason Crowell talks with Ed Silverman about the settlement over allegations that a patient charity helped MS drug makers pay kickbacks. You can read Mr. Silverman’s story in STAT: https://www.statnews.com/2019/11/20/patient-charity-allegations-ms-drug-makers-kickbacks/.

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. Quality improvement in dementia care: Dementia Management Quality Measurement Set 2018 implementation update
2. [What’s Trending]: Patient-Customized Oligonucleotide Therapy for a Rare Genetic Disease

In the first segment, Dr. Jason Crowell talks with Dr. Timothy Yu about patient-customized oligonucleotide therapy for a rare genetic disease. In the second part of the podcast, Dr. Jeffrey Burns talks with Dr. Amy Sanders about her implementation update on quality improvement in dementia care. You can read Dr. Yu’s paper in the NEJM: https://www.nejm.org/doi/full/10.1056/NEJMoa1813279.

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. A qualitative study on the price of drugs for multiple sclerosis: “Gaming the system”
2. [What’s Trending]: Duration of American football play and chronic traumatic encephalopathy

In the first segment, Dr. Jason Crowell talks with Dr. Daniel Hartung about his qualitative study on drug prices for MS. In the second part of the podcast, Dr. David Lapides talks with Dr. Jesse Mez about the duration of American football play and chronic traumatic encephalopathy. You can read Dr. Mez’s paper in the Annals of Neurology: https://onlinelibrary.wiley.com/doi/10.1002/ana.25611.

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. Longitudinal change in regional brain volumes with exposure to repetitive head impacts
2. [What’s Trending]: Infant colic and episodic syndromes

In the first segment, Dr. Jeffrey Ratliff talks with Dr. Charles Bernick about his paper on longitudinal change in regional brain volumes with exposure to repetitive head impacts. In the second part of the podcast, Dr. Teshamae Monteith talks with Dr. Amy Gelfand about infant colic and episodic syndromes.

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. Hashimoto encephalopathy in the 21st century
2. [What’s Trending]: Migraine Progression in Subgroups of Migraine Based on Comorbidities: Results of the CaMEO Study

In the first segment, Dr. Stacey Clardy talks with Dr. Francesc Graus and Dr. Josep Dalmau about their paper on Hashimoto encephalopathy in the 21st century. In the second part of the podcast, Dr. Teshamae Monteith talks with Dr. Richard Lipton and Dr. Dawn Buse about migraine progression in subgroups of migraine based on comorbidities.

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. Targeted, next-generation, sequencing panels in the diagnosis of Charcot-Marie-Tooth disease
2. [What’s Trending]: Gut Microbe to Brain Signaling: What Happens in Vagus…

In the first segment, Dr. Michelle Mauermann talks with Dr. Mary Reilly about her paper on targeted, next-generation, sequencing panels in the diagnosis of Charcot-Marie-Tooth disease. In the second part of the podcast, Dr. David Lapides talks with Dr. Christine Fulling about gut microbiota and brain signaling via the vagus nerve to affect brain and behavior.

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

This week, Dr. Ted Burns, creator and former editor of the Neurology Podcast, discusses the history, process, and meaning of the podcast.

This week, we feature past interviews with Dr. Mike Wilson on metagenomics.

Dr. Stacey Clardy talks with Nobel Laureate Peter Doherty about his collaborative work with Rolf Zinkernagel regarding how the body's immune system distinguishes virus-infected cells from normal cells, among many other topics.

1. Three-year follow-up of prospective trial of focused ultrasound thalamotomy for essential tremor
2. Statins for Neuroprotection in Spontaneous Intracerebral Hemorrhage

In the first segment, Dr. Jason Crowell talks with Dr. Casey Halpern about his paper on a three-year follow-up of a prospective trial of focused ultrasound thalamotomy for essential tremor. In the second part of the podcast, Dr. Will Rondeau talks with Dr. Jared Chen and Dr. Andrew Southerland about statins for neuroprotection in spontaneous intracerebral hemorrhage.

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. Treatment and prevention of neuromyelitis optica
2. Physical activity and prodromal features of Parkinson's disease

In the first segment, Dr. Ted Burns talks with Dr. Stacey Clardy about neuromyelitis optica. In the second part of the podcast, Dr. Jason Crowell talks with Dr. Alberto Ascherio about his paper on physical activity and prodromal features of Parkinson disease. 

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories
2. [What’s Trending]: gnostic indicators of improvement with therapeutic plasma exchange in pediatric demyelination

In the first segment, Dr. David Lapides talks with Dr. Thomas Kilduff about his Science report article reporting that REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories, which you can read here: https://science.sciencemag.org/content/365/6459/1308. In the second segment, Dr. Stacey Clardy talks with Dr. Sylvia Tenembaum about her paper on prognostic indicators of improvement with therapeutic plasma exchange in pediatric demyelination. 

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. Neurosyphilis
2. [What’s Trending]: Symptom burden among individuals with Parkinson disease: A national survey (Neurology: Clinical Practice)

In the opening segment, Dr. David Lapides talks with Dr. Allan Ropper about his NEJM paper on neurosyphilis, which you can read here: https://www.nejm.org/doi/full/10.1056/NEJMx190030. In the second part, Dr. Jeffrey Ratliff talks with Dr. Christopher Tarolli about his Neurology: Clinical Practice paper on symptom burden among individuals with Parkinson disease. 

Disclosures can be found at Neurology.org.

No CME this week: Interviews based on articles from Neurology® Clinical Practice, Neurology® Genetics, and Neurology® Neuroimmunology & Neuroinflammation are excluded from the CME program.

1. Editorial: Social Health and Brain Health: Does neurology also have a duty to treat social ills?
2. [What’s Trending]: Practice guideline update summary: Pharmacologic treatment for pediatric migraine prevention

In the first segment, Dr. Jason Crowell talks with Dr. Joel Salinas about his editorial on neurologists’ duty to treat social ills. In the second part of the podcast, Dr. Teshamae Monteith talks with Dr. Andrew Hershey about his practice guideline update summary paper in Neurology® on pharmacologic treatment for pediatric migraine prevention. You can read "Practice Guideline Update: Pharmacologic Treatment for Pediatric Migraine Prevention" here: https://www.aan.com/Guidelines/home/GuidelineDetail/967. For further reading, there is also "Practice Guideline Update: Acute Treatment of Migraine in Children and Adolescents" here: https://www.aan.com/Guidelines/home/GuidelineDetail/966. 

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. More prominent muscle involvement in dermatomyositis patients with anti-Mi2 autoantibodies
2. [What’s Trending]: Lawrence Weschler discusses Oliver Sacks, pt. 2

In the first segment, Dr. Stacey Clardy continues her talk with Lawrence Weschler about his book on Oliver Sacks, And How are You, Dr. Sacks?, in the second of a two-part interview.  In the second part of the podcast, Dr. Stacey Clardy talks with Dr. Andrew Mammen about his paper on more prominent muscle involvement in dermatomyositis patients with anti-Mi2 autoantibodies.

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. Autologous, nonmyeloablative hematopoietic stem-cell transplantation for neuromyelitis optica
2. [What’s Trending]: Lawrence Weschler discusses Oliver Sacks, pt. 1

In the first segment, Dr. Stacey Clardy talks with Dr. Richard Burt about his paper on autologous, nonmyeloablative hematopoietic stem-cell transplantation for neuromyelitis optica. In the second part of the podcast, Dr. Stacey Clardy speaks with Dr. Lawrence Weschler about his book on Oliver Sacks, And How are You, Dr. Sacks?, in the first of a two-part interview.

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. Testing Blood for Amyloid Beta-42 to Predict Future Brain Amyloidosis
2. [What’s Trending]: Nobel Laureate Stanley Prusiner about his impact on neurology, pt. 2

In the first segment, Dr. Jeff Burns talks with Dr. Randall Bateman about his paper addressing how high precision plasma amyloid-β 42/40 predicts current and future brain amyloidosis. In the second part of the podcast, you'll hear the second part of an interview with Nobel Prize winner Dr. Stanley H. Prusiner. 

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. Orthostatic hypotension in Parkinson disease: A 7-year prospective population-based study
2. [What’s Trending]: Nobel Laureate Stanley Prusiner about his impact on neurology, pt. 1

In the first segment, Dr. Jeffrey Ratliff talks with Dr. Ylva Hiorth and about their paper on a 7-year prospective population-based study on orthostatic hypotension in Parkinson disease. In the second part of the podcast, Dr. Jason Crowell talks with Nobel Prize winner Dr. Stanley B. Prusiner in the first of a two-part interview.

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. The World Health Organization’s essential diagnostics list: Diagnostics for neurologic disorders
2. [What’s Trending]: Eculizumab in Aquaporin-4–Positive Neuromyelitis Optica Spectrum Disorder

In the first segment, Dr. Greg Day talks with Dr. Kiran Thakur and Dr. Greer Waldrop about their paper on diagnostics for neurologic disorders on the World Health Organization’s essential diagnostic list. In the second part of the podcast, Dr. Stacey Clardy speaks with Dr. Sean Pittock on his NEJM paper on eculizumab in aquaporin-4–positive neuromyelitis optica spectrum disorder.

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. Combination therapy with nusinersen and AVXS-101 in SMA type 1
2. [What’s Trending]: Neuroimaging Findings in US Government Personnel With Possible Exposure to Directional Phenomena in Havana, Cuba

In the first segment, Dr. Jason Crowell talks with Dr. Emma Ciafaloni about her clinical/scientific note on combination therapy with nusinersen and AVXS-101 in SMA type 1. In the second part of the podcast, Dr. Jason Crowell speaks with Dr. Douglas Smith on neuroimaging findings in US government personnel with possible exposure to directional phenomena in Havana, Cuba.

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. Practice guideline update summary: Vaccine-preventable infections and immunization in multiple sclerosis
2. [What’s Trending]: Drug pricing update, part 2

In the first segment, Dr. Stacey Clardy talks with Dr. Mauricio Farez about his practice guideline update summary on vaccine-preventable infections and immunization in multiple sclerosis. In the second part of the podcast, Dr. Gordon Smith continues his discussion with Dr. Steve Pearson on an update on drug pricing. Their previous discussion on drug pricing was featured in two parts on January 8^th and January 15^th, 2019.

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. Understanding and addressing gender equity for women in neurology
2. [What’s Trending]: Drug pricing update, part 1

In the first segment, Dr. Stacey Clardy talks with Dr. Julie Silver about her paper on understanding and addressing gender equity for women in neurology. In the second part of the podcast, Dr. Gordon Smith focuses his discussion with Dr. Steve Pearson on an update on drug pricing. Their previous discussion on drug pricing was featured in two parts on January 8^th and January 15^th, 2019.

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. Varied Phenotypes and Management of Immune Checkpoint Inhibitor Associated Neuropathies
2. [What’s Trending]: Clinical Metagenomic Sequencing for Diagnosis of Meningitis and Encephalitis

In the first segment, Dr. Noah Kolb talks with Dr. Amanda Guidon about her paper on varied phenotypes and management of immune checkpoint inhibitor associated neuropathies. In the second part of the podcast, Dr. Stacey Clardy focuses her discussion with Dr. Mike R. Wilson on clinical metagenomic sequencing for diagnosis of meningitis and encephalitis. Read the full NEJM article here: https://www.nejm.org/doi/full/10.1056/NEJMoa1803396.

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. Therapy for acute nerve agent poisoning: An update (Neurology®: Clinical Practice)
2. [What’s Trending]: Detection of Brain Activation in Unresponsive Patients with Acute Brain Injury

In the first segment, Dr. Alex Menze talks with Dr. Jonathan Newmark about his Neurology: Clinical Practice paper that provides an update on therapy for acute nerve agent poisoning. In the second part of the podcast, Dr. Andrew Schomer focuses his discussion with Dr. Jan Claassen on detection of brain activation in unresponsive patients with acute brain injury. Read the full NEJM article here: https://www.nejm.org/doi/full/10.1056/NEJMoa1812757.   

Disclosures can be found at Neurology.org.

No CME this week: Interviews based on articles from Neurology® Clinical Practice, Neurology® Genetics, and Neurology® Neuroimmunology & Neuroinflammation are excluded from the CME program.

1. A large case-control study on vaccination as risk factor of multiple sclerosis
2. [What’s Trending]: Zika update 2019

In the first segment, Dr. David Lapides talks with Dr. Bernard Hemmer about his paper on a large case-control study on vaccination as risk factor of multiple sclerosis. In the second part of the podcast, Dr. Stacey Clardy focuses her discussion with Dr. Amanda Grennell on an update on Zika for 2019. Read the full article here: https://www.nature.com/articles/d41586-019-01906-z.   

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. Phosphodiesterase 10A-IgG: A novel biomarker of paraneoplastic neurological autoimmunity
2. [What’s Trending]: "Evergreening" and drug prices

In the first segment, Dr. Stacey Clardy talks with Dr. Anastasia Zekeridou about her paper on Phosphodiesterase 10A-IgG, a novel biomarker of paraneoplastic neurological autoimmunity. In the second part of the podcast, Dr. Jason Crowell focuses his discussion with Prof. Robin Feldman on “evergreening” and drug prices. Read the full article here: https://www.nature.com/articles/d41586-019-01906-z.   

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. Impulse control disorders in Parkinson disease and RBD: A longitudinal study of severity
2. [What’s Trending]: CRISPR babies: when will the world be ready?

In the first segment, Dr. Jason Crowell talks with Dr. Michele Hu and Dr. David Okai about their longitudinal study of the severity of impulse control disorders in Parkinson disease and RBD. In the second part of the podcast, Dr. Jason Crowell focuses his discussion with Dr. Heidi Ledford on her Nature article discussing CRISPR babies and what would be required to make gene editing safe and acceptable. Read the full article here: https://www.nature.com/articles/d41586-019-01906-z.   

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. Cumulative gadodiamide administration leads to brain gadolinium deposition in early MS
2. [What's Trending]: Network localization of cervical dystonia based on causal brain lesions

In the first segment, Dr. Stacey Clardy talks with Dr. Robert Zivadinov about cumulative gadodiamide administration leading to brain gadolinium deposition in early MS. In the second part of the podcast, Dr. Jeffrey Ratliff focuses his discussion with Dr. Michael D. Fox on his Brain paper on network localization of cervical dystonia based on causal brain lesions. You can read the paper here: https://academic.oup.com/brain/article-abstract/142/6/1660/5491101?redirectedFrom=fulltext.  

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. CDC’s Guideline on Pediatric Mild Traumatic Brain Injury: Recommendations for Neurologists (Neurology: Clinical Practice)
2. [What's Trending]: Thrombolysis Guided by Perfusion Imaging up to 9 Hours after Onset of Stroke

In the first segment, Dr. Kristen Heinan talks with Dr. Barbara Weissman about her Neurology: Clinical Practice paper on recommendations for neurologists on the CDC’s Guideline on Pediatric Mild Traumatic Brain Injury. In the second part of the podcast, Dr. Will Rondeau focuses his discussion with Dr. Geoffrey Donnan on his NEJM paper on thrombolysis guided by perfusion Imaging up to 9 hours after onset of stroke. You can read the paper here: https://www.nejm.org/doi/pdf/10.1056/NEJMoa1813046.

Disclosures can be found at Neurology.org.

1. Determining clinically meaningful decline in preclinical Alzheimer disease
2. [What's Trending]: Targeting Huntington expression in patients with Huntington's disease

In the first segment, Dr. Gregory Day talks with Dr. Philip Insel about his paper on determining clinically meaningful decline in preclinical Alzheimer disease. In the second part of the podcast, Dr. Sarah Tabrizi talks about targeting Huntington expression in patients with Huntington's disease in her interview with Dr. Jeffrey Ratliff. Read Dr. Tabrizi's paper in NEJM: https://www.nejm.org/doi/full/10.1056/NEJMoa1900907?query=recirc_curatedRelated_article. 

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. SUDEP in the North American SUDEP Registry: The full spectrum of epilepsies
2. [What's Trending]: Long-term effect of thymectomy plus prednisone versus prednisone alone in patients with non-thymomatous myasthenia gravis: 2-year extension of the MGTX randomised trial

In the first segment, Dr. Halley Alexander talks with Dr. Orrin Devinsky about his paper on the full spectrum of epilepsies and the North American SUDEP Registry. In the second part of the podcast, Dr. Ted Burns focuses his discussion with Dr. Gil Wolfe on his Lancet Neurology paper on the long-term effect of thymectomy plus prednisone versus prednisone alone in patients with non-thymomatous myasthenia gravis. You can read the paper here: https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(18)30392-2/fulltext.  

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. Use of ß2-adrenoreceptor agonist and antagonist drugs and risk of Parkinson disease
2. [What's Trending]: The US Food and Drug Administration’s Authorization of the First Cannabis-Derived Pharmaceutical

In the first segment, Dr. Jeffrey Ratliff talks with Dr. Franziska Hopfner about her paper on the use of ß2-adrenoreceptor agonist and antagonist drugs and risk of Parkinson disease. In the second part of the podcast, Dr. Jason Crowell focuses his discussion with Dr. Jerzy Szaflarski on his JAMA Neurology paper on the US Food and Drug Administration’s authorization of the first cannabis-derived pharmaceutical. You can read the paper here: https://jamanetwork.com/journals/jamaneurology/article-abstract/2714720.

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. Current treatment practice of Guillain-Barré syndrome
2. [What's Trending]: Somatic expansion of the C9orf72 Hexanucleotide Repeat does not occur in ALS spinal cord tissues (Neurology: Genetics)

In the first segment, Dr. Michelle Mauermann talks with Dr. Bart Jacobs about his paper on current treatment practice of Guillain-Barré syndrome. In the second part of the podcast, Dr. Matthew Harms focuses his discussion with Dr. Guy Rouleau on his Neurology: Genetics paper looking at how somatic expansion of the C9orf72 Hexanucleotide Repeat does not occur in ALS spinal cord tissues.

1. Interview with Neurology Editor-in-Chief Bob Gross, pt. 2

In the second part of a 2-part interview, Dr. Bob Gross changes to the journal and publishing as well as some controversies and challenges as Editor-in-Chief of Neurology.

1. Interview with Neurology Editor-in-Chief Bob Gross, pt. 1

In the first part of a 2-part interview, Dr. Bob Gross discusses his experiences, opportunities, and challenges as Editor-in-Chief of Neurology.

1. Lumbosacral Radiculoplexus Neuropathy: Incidence and the Association with Diabetes Mellitus

2. [What’s Trending]: CRGP monoclonal antibodies for migraine prevention

In the first segment, Dr. Stacey Clardy talks with Dr. P. James B. Dyck about his paper on the incidence of lumbrosacral radiculoplexus neuropathy and association with diabetes mellitus, from the March 12th issue. In the second segment, Dr. David Lapides talks with Dr. Teshamae Monteith about the use of CRGP monoclonal antibodies for migraine prevention. 

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. The Four Score as a predictor of outcome in adults with bacterial meningitis

2. [What’s Trending]:Opioid prescribing and response to the CDC guidelines

In the first segment, Dr. David Lapides talks with Dr. C.N. van Ettekoven about the Four Score as a predictor of outcome in adults with bacterial meningitis, from the May 28th issue. In the second part of the podcast, Dr. Jason Crowell focuses his talk with Dr. Deborah Dowell on her NEJM perspective article looking at opioid prescribing and response to the CDC guidelines. You can read Dr. Dowell’s paper here: https://www.nejm.org/doi/full/10.1056/NEJMp1904190.

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. Out-of-pocket Costs are on the Rise for Commonly Prescribed Neurologic Medications

2. [What’s Trending]: Diagnosing Genetic Ataxias

In the first segment, Dr. Jason Crowell talks with Dr. Brian Callaghan about the rising out-of-pocket costs for commonly prescribed neurologic medications. In the second part of the podcast, Dr. Jeffrey Ratliff focuses his interview with Dr. Stefan Pulst on diagnosing genetic ataxias.

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. Long-term outcome in neuroZika: When biological diagnosis matters

2. [What’s Trending]: Full Study Report of Andexanet Alfa for Bleeding Associated with Factor Xa Inhibitors (NEJM)

In the first segment, Dr. Stacey Clardy talks with Dr. Annie Lannuzel about the importance of biological diagnosis in long-term outcome in neuroZika. In the second part of the podcast, Dr. Will Rondeau focuses his interview with Dr. Stuart Connolly on his NEJM paper on the full study report of andexanet alfa for bleeding associated with factor Xa inhibitors. The paper can be found here: https://www.nejm.org/doi/full/10.1056/NEJMoa1814051.

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. Meta-analysis and cost-effectiveness of second-line antiepileptic drugs for status epilepticus 

2. [What’s Trending]: Measles in 2019

In the first segment, Dr. Lindsay Higdon talks with Dr. Ivan Sanchez Fernandez about his paper on the meta-analysis and cost-effectiveness of second-line antiepileptic drugs for status epilepticus. In the second part of the podcast, Dr. Stacey Clardy talks with Dr. Anthony Fauci about the measles outbreak of 2019. You can read the paper in NEJM: https://www.nejm.org/doi/full/10.1056/NEJMp1905099. 

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. Practice guideline recommendations summary: The treatment of tics in people with Tourette syndrome and chronic tic disorders 

2. [What’s Trending]: CRISPR and gene editing, pt. 2

In the first segment, Dr. Jeffrey Ratliff talks with Dr. Tamara Milka Pringsheim about her practice guideline recommendations summary paper on the treatment of tics in people with Tourette syndrome and chronic tic disorders. In the What's Trending segment, you'll hear the second part of an interview between Dr. Jason Crowell and New York Times staff writer Pam Belluck on CRISPR and gene editing.

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. Neurology: Neuroimmunology & Neuroinflammation: Mouse model of anti-NMDA receptor post–herpes simplex encephalitis 

2. [What’s Trending]: CRISPR & Gene Editing 

In the first segment, Dr. Stacey Clardy talks with Dr. Jenny Linnoila about her March 2019 Neurology: Neuroimmunology & Neuroinflammation paper on a mouse model of anti-NMDA receptor post–herpes simplex encephalitis. In the second part of the podcast, you will hear the first part of a 2-part interview about CRISPR and gene editing with New York Times staff writer Pam Belluck and Dr. Jason Crowell. You can read the NYT story here: https://www.nytimes.com/2019/04/14/health/gene-editing-babies.html?rref=collection%2Fbyline%2Fpam-belluck.

And, you will find the follow up here: https://www.nytimes.com/2019/04/16/health/stanford-gene-editing-babies.html?rref=collection%2Fbyline%2Fpam-belluck

Disclosures can be found at Neurology.org.

No CME this week: Interviews based on articles from Neurology® Clinical Practice, Neurology® Genetics, and Neurology® Neuroimmunology & Neuroinflammation are excluded from the CME program.

1. Neurology: Clinical Practice: Montreal Cognitive Assessment as a screening tool: Influence of performance and symptom validity 

2. [What’s Trending]:  Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease  

In the first segment, Dr. Gregory Day talks with Dr. Brigid Waldron-Perrine about her Neurology: Clinical Practice paper addressing the Montreal Cognitive Assessment as a screening tool. In the second part of the podcast, Dr. Jeffrey Burns focuses his interview with Dr. Mathias Jucker on how serum neurofilament dynamics predict neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease. The article can be found in Nature: https://www.nature.com/articles/s41591-018-0304-3.

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. Comparative effectiveness of teriflunomide and dimethyl fumarate. A nationwide cohort study

2. [What’s Trending]: The Rise of Pseudomedicine for Dementia and Brain Health

In the first segment, Dr. Stacey Clardy talks with Dr. Mathias Buron about his paper addressing the comparative effectiveness of teriflunomide and dimethyl fumarate. In the second part of the podcast, Dr. Jason Crowell focuses his interview with Dr. Joanna Hellmuth on the rise of pseudomedicine for dementia and brain health.

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. How much do periventricular lesions assist in distinguishing migraine with aura from CIS?

2. [What’s Trending]: Drug Pricing--Politico

In the first segment, Dr. Stacey Clardy talks with Dr. Caterina Lapucci about her paper addressing how much periventricular lesions assist in distinguishing migraine with aura from CIS. In the second part of the podcast, Dr. Jason Crowell focuses his interview with Sarah Karlin-Smith and Sarah Owermohle from Politico on drug pricing.

Disclosures can be found at Neurology.org.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. Automated seizure detection accuracy for ambulatory EEG recordings

2. [What’s Trending]: SHINE Stroke Trial

In the first segment, Dr. Derek Bauer talks with Dr. Stephan Schuele about his paper on automated seizure detection accuracy for ambulatory EEG recordings. In the second part of the podcast, Dr. Nicole Chiota-McCollum focuses her interview with Dr. Kevin Barrett on the SHINE stroke trial.

CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.